Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila
Journal Article
Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., …Longbottom, D. (2016)
Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports, 6, 37150. https://doi.org/10.1038/srep37150
Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in catt...
Excess Androgens in Utero Alters Fetal Testis Development.
Journal Article
Connolly, F., Rae, M. T., Bittner, L., Hogg, K., McNeilly, A. S., & Duncan, W. C. (2013)
Excess Androgens in Utero Alters Fetal Testis Development. Endocrinology, 154, 1921-1933. https://doi.org/10.1210/en.2012-2153
Prenatal androgenization induces a polycystic ovary syndrome-like phenotype in adult female offspring, which is associated with alterations that can be detected in the fetal o...
In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers.
Journal Article
Kermanizadeh, A., Pojana, G., Gaiser, B. K., Birkedal, R., Bilanicˇová, D., Wallin, H., …Stone, V. (2013)
In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers. Nanotoxicology, 7, 301-313. https://doi.org/10.3109/17435390.2011.653416
Effects on the liver C3A cell line treated with a panel of engineered nanomaterials (NMs) consisting of two zinc oxide particles (ZnO; coated 100 nm and uncoated 130 nm), two ...
Cartilage to bone transitions in health and disease
Journal Article
Staines, K. A., Pollard, A. S., McGonnell, I. M., Farquharson, C., & Pitsillides, A. A. (2013)
Cartilage to bone transitions in health and disease. Journal of Endocrinology, 219(1), R1-R12. https://doi.org/10.1530/joe-13-0276
Aberrant redeployment of the 'transient' events responsible for bone development and postnatal longitudinal growth has been reported in some diseases in what is otherwise inhe...
The Pancreas Is Altered by In Utero Androgen Exposure: Implications for Clinical Conditions Such as Polycystic Ovary Syndrome (PCOS)
Journal Article
Franks, S., Rae, M. T., Grace, C., Hogg, K., Wilson, L. M., McHaffie, S. L., …Duncan, C. (2013)
The Pancreas Is Altered by In Utero Androgen Exposure: Implications for Clinical Conditions Such as Polycystic Ovary Syndrome (PCOS). PLOS ONE, 8(2), https://doi.org/10.1371/journal.pone.0056263
Using an ovine model of polycystic ovary syndrome (PCOS), (pregnant ewes injected with testosterone propionate (TP) (100 mg twice weekly) from day (d)62 to d102 of d147 gestat...
Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ
Journal Article
Kermanizadeh, A., Brown, D. M., Hutchison, G. R., & Stone, V. (2012)
Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ. Journal of Nanomedicine and Nanotechnology, 4, 157. https://doi.org/10.4172/2157-7439.1000157
Background and methods: Following exposure via a number of routes (inhalation, ingestion or injection), some
Nanomaterials (NMs) translocate to secondary tissues, prominently ...
The intermediate filament protein, vimentin, is a regulator of NOD2 activity
Journal Article
Stevens, C., Henderson, P., Nimmo, E. R., Soares, D. C., Dogan, B., Simpson, K. W., …Satsangi, J. (2013)
The intermediate filament protein, vimentin, is a regulator of NOD2 activity. Gut, 62(5), 695-707. https://doi.org/10.1136/gutjnl-2011-301775
Objective Mutations in the nucleotide-binding oligomerisation domain-containing protein 2 (NOD2) gene remain the strongest genetic determinants for Crohn's disease (CD). Havin...
Co-induction of cyclooxyenase-2 and early growth response gene (Egr-1) in spinal cord in a clinical model of persistent inflammation and hyperalgesia
Journal Article
Dolan, S., Hastie, P. G. R., Crossan, C., & Nolan, A. M. (2011)
Co-induction of cyclooxyenase-2 and early growth response gene (Egr-1) in spinal cord in a clinical model of persistent inflammation and hyperalgesia. Molecular Pain, 7, 91. https://doi.org/10.1186/1744-8069-7-91
Background
This study characterised the effects of persistent peripheral inflammation of the foot on pain and spinal cord expression of cyclooxygenase-1 and -2 (COX-1 and COX...
The skeleton: no bones about it
Journal Article
Farquharson, C., & Staines, K. (2011)
The skeleton: no bones about it. Journal of Endocrinology, 211(2), 107-108. doi:10.1530/joe-11-0274
NO abstract available.
The lack of associations between alleles at the hypoxia-Inducible factor 1A C1772T loci and responses to acute hypoxia
Journal Article
Hennis, P. J., Bussell, C., & Darlison, M. G. (2010)
The lack of associations between alleles at the hypoxia-Inducible factor 1A C1772T loci and responses to acute hypoxia. Wilderness and Environmental Medicine, 21, 219-228. https://doi.org/10.1016/j.wem.2010.05.001
Objective
The aim of this study was to investigate the associations between alleles of the hypoxia-inducible factor 1A (HIF1A) C1772T polymorphism and several physiological r...