An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions
Journal Article
Smith, K., Muggeridge, D. J., Easton, C., & Ross, M. D. (2019)
An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions. European Journal of Applied Physiology, 119(3), 723-733. https://doi.org/10.1007/s00421-018-04063-9
Purpose: Dietary nitrate (NO3-) has repeatedly been shown to improve endurance and intermittent, high-intensity events in temperate conditions. However, the ergogenic effects...
The efficacy of certain anti-tuberculosis drugs is affected by binding to alpha-1-acid glycoprotein.
Journal Article
Johnson, D. A. & Smith, K. (2006)
The efficacy of certain anti-tuberculosis drugs is affected by binding to alpha-1-acid glycoprotein. Biomedical Chromatography. 20, 551-560. doi:10.1002/bmc.641. ISSN 0269-3879
One of the most ubiquitous plasma proteins, -1-acid glycoprotein (AGP), has a high affinity, low capacity binding for basic drugs positively charged at physiological pH. Moreo...
A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases.
Journal Article
Anderson, N. E., Pollacchi, A., Hayes, P., Therapondos, G., Newsome, P., Boyter, A. & Smith, K. (2002)
A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases. Biomedical Chromatography. 16, 365-372. doi:10.1002/bmc.167. ISSN 0269-3879
During the acute phase response (APR) to tissue injury or infection, the liver is responsible for the level of mediators such as cytokines required at the site of inflammation...
Alpha-1-acid glycoprotein expressed in the plasma of chronic myeloid leukemia patients does not mediate significant in vitro resistance to STI571.
Journal Article
Jørgensen, H. G., Elliott, M. A., Allan, E. K., Carr, C. E., Holyoake, T. L. & Smith, K. (2002)
Alpha-1-acid glycoprotein expressed in the plasma of chronic myeloid leukemia patients does not mediate significant in vitro resistance to STI571. Blood. 99, 713-715. doi:10.1182/blood.V99.2.713. ISSN 0006-4971
Despite the efficacy of STI571 (Glivec, Novartis, Basle, Switzerland) in treating chronic myeloid leukemia (CML), drug resistance has already been noted both in vitro and in v...