Quantum Dots: An investigation into how differing surface characteristics affect their interaction with macrophages in vitro
Thesis
Clift, M. J. D. Quantum Dots: An investigation into how differing surface characteristics affect their interaction with macrophages in vitro. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/2557
Quantum dots (QDs) are potentially advantageous tools for both diagnostics and therapeutics due to their light emitting characteristics. The impact of QDs on biological system...
Investigating the frequency of senescent T lymphocytes with ageing, exercise and obesity
Thesis
Cosgrove, C. Investigating the frequency of senescent T lymphocytes with ageing, exercise and obesity. (Thesis)
Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/2491
Cellular senescence is a state of permanent cell cycle arrest in which a cell is unable to further divide in response to normal growth stimuli. Telomere shortening, believed ...
ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2
Journal Article
Stevens, C., Pettersson, S., Wawrzynow, B., Wallace, M., Ball, K., Zylicz, A., & Hupp, T. R. (2008)
ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2. FEBS Journal, 275(19), 4875-4886. https://doi.org/10.1111/j.1742-4658.2008.06627.x
Murine double minute 2 (MDM2) protein exhibits many diverse biochemical functions on the tumour suppressor protein p53, including transcriptional suppression and E3 ubiquitin ...
Novel insights into DAPK autophagic signalling using peptide aptamer combinatorial protein-interaction screens
Journal Article
Stevens, C. & Hupp, T. R. (2008)
Novel insights into DAPK autophagic signalling using peptide aptamer combinatorial protein-interaction screens. Autophagy. 4(4), 531-533. doi:10.4161/auto.5940. ISSN 1554-8627
DAPK represents a relatively unique enzyme in the protein kinase superfamily whose major biological functions are linked to both autophagy and signal-mediated apoptosis. Howev...
Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise
Journal Article
Simpson, R. J., Cosgrove, C., Ingram, L. A., Florida-James, G. D., Whyte, G. P., Pircher, H., & Guy, K. (2008)
Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise. Brain, Behavior, and Immunity, 22(4), 544-551. https://doi.org/10.1016/j.bbi.2007.11.002
Senescent T-lymphocytes are antigen-experienced cells that express the killer-cell lectin-like receptor G1 (KLRG1) and/or CD57; fail to clonally expand following further antig...
Effect of age on 16.1km time trial performance.
Journal Article
Balmer, J., Bird, S. R., Davison, R. & Lucia, A. (2008)
Effect of age on 16.1km time trial performance. Journal of Sports Sciences. 26, 197-206. doi:10.1080/02640410701446901. ISSN 0264-0414
In this study, we assessed the performance of trained senior (n = 6) and veteran (n = 6) cyclists (mean age 28 years, s = 3 and 57 years, s = 4 respectively). Each competitor ...
Effect of instrument attachment on the surface temperature of juvenile grey seals (Halichoerus Grypus) measured by infrared thermography.
Journal Article
McCafferty, D. J., Currie, J. & Sparling, C. E. (2007)
Effect of instrument attachment on the surface temperature of juvenile grey seals (Halichoerus Grypus) measured by infrared thermography. Deep Sea Research Part II Topical Studies in Oceanography. 54, 424-436. doi:10.1016/j.dsr2.2006.11.019
Previous research has highlighted the importance of minimising hydrodynamic drag from biologging instruments fitted to marine mammals. However, there is a need to investigate ...
High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects.
Journal Article
Simpson, R. J., Florida-James, G., Cosgrove, C., Whyte, G. P., Macrae, S., Pircher, H., & Guy, K. (2007)
High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects. Journal of Applied Physiology, 103, 396-401. https://doi.org/10.1152/japplphysiol.00007.2007
Clonal expansion of T lymphocytes in response to antigenic stimulation is a fundamental process of adaptive immunity. As a consequence of clonal expansion, some T lymphocytes ...
The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells.
Journal Article
Simpson, R. J., Florida-James, G., Whyte, G. P., Middleton, N., Shave, R., George, K., & Guy, K. (2007)
The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells. European Journal of Applied Physiology, 99, 201-204. https://doi.org/10.1007/s00421-006-0326-2
Exercise is known to result in the haemolysis of red blood cells (RBCs). Although mechanical stressors such as footstrike and an increased velocity of blood flow may be involv...
Impact of repeated prolonged exercise bouts on cardiac function and biomarkers.
Journal Article
Middleton, N., Shave, R., George, K., Whyte, G. P., Simpson, R. J., Florida-James, G. & Gaze, D. (2007)
Impact of repeated prolonged exercise bouts on cardiac function and biomarkers. Medicine and Science in Sports and Exercise. 39, 83-90. doi:10.1249/01.mss.0000239395.93578.60. ISSN 0195-9131
Purpose: The present study examined the impact of repeated bouts of prolonged (
Methods: Ten athletes completed a 15.3-mile hill run on three consecutive days and were assesse...