Pancreatic and adrenal development and function in an ovine model of polycystic ovary syndrome
Thesis
Ramaswamy, S. Pancreatic and adrenal development and function in an ovine model of polycystic ovary syndrome. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/id/eprint/9826
Polycystic Ovary Syndrome (PCOS) is a complex disorder encompassing reproductive and metabolic dysfunction. Ovarian hyperandrogenism is an endocrine hallmark of human PCOS. In...
In an ovine model of polycystic ovary syndrome (PCOS) prenatal androgens suppress female fetal renal gluconeogenesis.
Journal Article
Kanellopoulos-Langevin, C., Connolly, F., Rae, M. T., Späth, K., Boswell, L., McNeilly, A. S., & Duncan, W. C. (2015)
In an ovine model of polycystic ovary syndrome (PCOS) prenatal androgens suppress female fetal renal gluconeogenesis. PLOS ONE, 10, https://doi.org/10.1371/journal.pone.0132113
Increased maternal androgen exposure during pregnancy programmes a polycystic ovary syndrome (PCOS)-like condition, with metabolic dysfunction, in adult female offspring. Othe...
Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development.
Journal Article
Girardi, G., Fraser, J. A., Lennen, R., Vontell, R., Jansen, M., & Hutchison, G. (2015)
Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development. Molecular Psychiatry, 20, 1017-1026. https://doi.org/10.1038/mp.2014.110
In the current study, we have developed a magnetic resonance imaging-based method for non-invasive detection of
complement activation in placenta and foetal brain in vivo in u...
Is counselling necessary? Making the decision to have an abortion. A qualitative interview study.
Journal Article
Brown, S. (2013)
Is counselling necessary? Making the decision to have an abortion. A qualitative interview study. European Journal of Contraception and Reproductive Health Care, 18, 44-48. https://doi.org/10.3109/13625187.2012.750290
Objectives To explore young women’s decision-making about having an abortion, in particular, how they reached the decision and with whom they discussed it.
Methods Qualitative...
Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas
Journal Article
Gubbay, O., Guo, W., Rae, M. T., Niven, D., Langdon, S. P., & Hillier, S. G. (2005)
Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas. British Journal of Cancer, 92, 1927-1933. https://doi.org/10.1038/sj.bjc.6602568
Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with in...
Characterisation of GABAA receptors and cation-chloride cotransporters in the uterus and their role in pre-term labour
Thesis
Sutherland, M. L. Characterisation of GABAA receptors and cation-chloride cotransporters in the uterus and their role in pre-term labour. (Thesis)
Edinburgh napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/1255142
GABAA receptor (GABAAR) function may be inhibitory or excitatory in the brain depending on the chloride electrochemical gradient over the neuronal membrane. This gradient is t...
Interpersonal trauma, substance misuse and pregnancy: A phenomenological exploration of pregnant women and midwives in Scotland
Thesis
Waddell, N. M. Interpersonal trauma, substance misuse and pregnancy: A phenomenological exploration of pregnant women and midwives in Scotland. (Thesis)
Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/1255223
Background: The relationship between interpersonal trauma (IPT) and substance misuse is complex and multi-factorial, but has not been examined fully in the existing few studie...
Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release
Journal Article
Giakoumelou, S., Wheelhouse, N., Brown, J., Wade, J., Simitsidellis, I., Gibson, D., …Horne, A. W. (2017)
Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release. Scientific Reports, 7(1), https://doi.org/10.1038/s41598-017-02223-z
Miscarriage affects ~20% of pregnancies and 30 maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but ...
Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFkappaB activation resulting in a microenvironment predisposed to ectopic pregnancy
Journal Article
Shaw, J. L. V., Wills, G. S., Lee, K., Horner, P. J., McClure, M. O., Abrahams, V. M., …Horne, A. W. (2011)
Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFkappaB activation resulting in a microenvironment predisposed to ectopic pregnancy. American Journal of Pathology, 178(1), 253-60. https://doi.org/10.1016/j.ajpath.2010.11.019
Chlamydia trachomatis and smoking are major risk factors for tubal ectopic pregnancy (EP), but the underlying mechanisms of these associations are not completely understood. F...
Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment
Journal Article
Ahmad, S. F., Brown, J. K., Campbell, L. L., Koscielniak, M., Oliver, C., Wheelhouse, N., …Horne, A. W. (2018)
Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment. EBioMedicine, 29, 159-165. https://doi.org/10.1016/j.ebiom.2018.02.020
Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo...