Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ
Journal Article
Kermanizadeh, A., Brown, D. M., Hutchison, G. R., & Stone, V. (2012)
Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ. Journal of Nanomedicine and Nanotechnology, 4, 157. https://doi.org/10.4172/2157-7439.1000157
Background and methods: Following exposure via a number of routes (inhalation, ingestion or injection), some
Nanomaterials (NMs) translocate to secondary tissues, prominently ...
Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy
Journal Article
Zhu, D., Farcal, L., Torres Andón, F., Di Cristo, L., Rotoli, B. M., Bussolati, O., …Fadeel, B. (2015)
Comprehensive In Vitro Toxicity Testing of a Panel of Representative Oxide Nanomaterials: First Steps towards an Intelligent Testing Strategy. PLOS ONE, 10, https://doi.org/10.1371/journal.pone.0127174
Nanomaterials (NMs) display many unique and useful physico-chemical properties. However, reliable approaches are needed for risk assessment of NMs. The present study was perfo...
The effect of refurbishing a UK steel plant on PM10 metal composition and ability to induce inflammation
Journal Article
Hutchison, G. R., Brown, D. M., Hibbs, L. R., Heal, M. R., Donaldson, K., Maynard, R. L., …Stone, V. (2005)
The effect of refurbishing a UK steel plant on PM10 metal composition and ability to induce inflammation. Respiratory Research, 6(1), 43. https://doi.org/10.1186/1465-9921-6-43
In the year 2000 Corus closed its steel plant operations in Redcar, NE of England temporarily for refurbishment of its blast furnace. This study investigates the impact of the...
An in vitro liver model - assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials
Journal Article
Kermanizadeh, A., Gaiser, B. K., Hutchison, G. R., & Stone, V. (2012)
An in vitro liver model - assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials. Particle and fibre toxicology, 9(1), 28. https://doi.org/10.1186/1743-8977-9-28
Background:
Following exposure via inhalation, intratracheal instillation or ingestion some nanomaterials (NM) have been shown to translocate to the liver. Since oxidative str...
Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation
Journal Article
Wilson, M. R., Foucaud, L., Barlow, P. G., Hutchison, G. R., Sales, J., Simpson, R. J., & Stone, V. (2007)
Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation. Toxicology and Applied Pharmacology, 225(1), 80-89. https://doi.org/10.1016/j.taap.2007.07.012
Particulate air pollution (PM10) consists of a mixture of components, including nanoparticles and metals. Studies from our laboratory have demonstrated that transition metals ...
Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials
Journal Article
Martin, S., de Haan, L., Miro Estruch, I., Eder, K. M., Marzi, A., Schnekenburger, J., …Bouwmeester, H. (2022)
Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials. Frontiers in Toxicology, 4, Article 974429. https://doi.org/10.3389/ftox.2022.974429
Engineered nanomaterials have been found to induce oxidative stress. Cellular oxidative stress, in turn, can result in the induction of antioxidant and detoxification enzymes ...
Effects of di(n-butyl) phthalate exposure on foetal rat germ-cell number and differentiation: identification of age-specific windows of vulnerability: DBP effects on foetal germ cells
Journal Article
Jobling, M. S., Hutchison, G. R., van den Driesche, S., & Sharpe, R. M. (2011)
Effects of di(n-butyl) phthalate exposure on foetal rat germ-cell number and differentiation: identification of age-specific windows of vulnerability: DBP effects on foetal germ cells. International Journal of Andrology, 34(5pt2), e386-e396. https://doi.org/10.1111/j.1365-2605.2010.01140.x
Environmental factors are implicated in increased incidence of human testicular germ‐cell cancer (TGCC). TGCC has foetal origins and may be one component of a testicular dysge...
Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system.
Presentation / Conference
Malone, E., Ross, B., Rae, M., Bouwmeester, H., Gosens, I., Cassee, F., …Hutchison, G. (2016, September)
Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. Poster presented at 11th International Particle Toxicology Conference, Singapore
The introduction of engineered nanomaterials (ENM) to new materials and products requires informed risk
assessment. The altered physico-chemical properties of ENM mean traditi...
Comparative Effects of Di(n-Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts
Journal Article
van den Driesche, S., McKinnell, C., Calarrão, A., Kennedy, L., Hutchison, G. R., Hrabalkova, L., …Mitchell, R. T. (2015)
Comparative Effects of Di(n-Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts. Environmental Health Perspectives, 123(3), 223-230. https://doi.org/10.1289/ehp.1408248
Background: Phthalate exposure induces germ cell effects in the fetal rat testis. Although experimental models have shown that the human fetal testis is insensitive to the ste...
Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development.
Journal Article
Girardi, G., Fraser, J. A., Lennen, R., Vontell, R., Jansen, M., & Hutchison, G. (2015)
Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development. Molecular Psychiatry, 20, 1017-1026. https://doi.org/10.1038/mp.2014.110
In the current study, we have developed a magnetic resonance imaging-based method for non-invasive detection of
complement activation in placenta and foetal brain in vivo in u...