Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling
Journal Article
Bolukbasi, E., Vass, S., Cobbe, N., Nelson, B., Simossis, V., Dunbar, D. R., & Heck, M. M. S. (2012)
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. Open Biology, 2(1), 110031-110031. https://doi.org/10.1098/rsob.110031
Multi-cellular organisms need to successfully link cell growth and metabolism to environmental cues during development. Insulin receptor–target of rapamycin (InR–TOR) signalli...
Perturbation of invadolysin disrupts cell migration in zebrafish (Danio rerio)
Journal Article
Vass, S., & Heck, M. M. S. (2013)
Perturbation of invadolysin disrupts cell migration in zebrafish (Danio rerio). Experimental Cell Research, 319(8), 1198-1212. https://doi.org/10.1016/j.yexcr.2013.02.005
Invadolysin is an essential, conserved metalloprotease which links cell division with cell migration and is intriguingly associated with lipid droplets. In this work we examin...
Depletion of Drad21/Scc1 in Drosophila Cells Leads to Instability of the Cohesin Complex and Disruption of Mitotic Progression
Journal Article
Vass, S., Cotterill, S., Valdeolmillos, A. M., Barbero, J. L., Lin, E., Warren, W. D., & Heck, M. M. (2003)
Depletion of Drad21/Scc1 in Drosophila Cells Leads to Instability of the Cohesin Complex and Disruption of Mitotic Progression. Current Biology, 13(3), 208-218. doi:10.1016/S0960-9822(03)00047-2
Background: The coordination of cell cycle events is necessary to ensure the proper duplication and dissemination of the genome. In this study, we examine the consequences of ...
Heart on a Plate: Histological and Functional Assessment of Isolated Adult Zebrafish Hearts Maintained in Culture
Journal Article
Pieperhoff, S., Wilson, K. S., Baily, J., de Mora, K., Maqsood, S., Vass, S., …Denvir, M. A. (2014)
Heart on a Plate: Histological and Functional Assessment of Isolated Adult Zebrafish Hearts Maintained in Culture. PLOS ONE, 9(5), https://doi.org/10.1371/journal.pone.0096771
The zebrafish is increasingly used for cardiovascular genetic and functional studies. We present a novel protocol to maintain and monitor whole isolated beating adult zebrafis...
Invadolysin acts genetically via the SAGA complex to modulate chromosome structure
Journal Article
Janiszewski, M. M., Heck, M. M., Rao, S. G., Janiszewski, M. M., Duca, E., Nelson, B., …Heck, M. M. S. (2015)
Invadolysin acts genetically via the SAGA complex to modulate chromosome structure. Nucleic Acids Research, 43(7), 3546-3562. https://doi.org/10.1093/nar/gkv211
Identification of components essential to chromosome structure and behaviour remains a vibrant area of study. We have previously shown that invadolysin is essential in Drosoph...
Margarete Heck (1959–2023): Cell biologist, geneticist, and incandescent social spark
Journal Article
Cobbe, N., Di Cara, F., Spradling, A. C., & Vass, S. (2024)
Margarete Heck (1959–2023): Cell biologist, geneticist, and incandescent social spark. Journal of Cell Biology, 223(1), Article e202311145. https://doi.org/10.1083/jcb.202311145