Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field
Journal Article
Fullerton, J., Bettencourt, C., Daniels, M., Mclean, F., Simpson, S., Smith, A., …Kerr, F. (2022)
Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field. AMRC Open Research, 4, Article 22. https://doi.org/10.12688/amrcopenres.13091.1
Background
Effective development and retention of talented early-career researchers (ECRs) is essential to the continued success of biomedical science research fields. To this...
Deletion of endogenous Tau proteins is not detrimental in Drosophila
Journal Article
Burnouf, S., Grönke, S., Augustin, H., Dols, J., Gorsky, M. K., Werner, J., …Partridge, L. (2016)
Deletion of endogenous Tau proteins is not detrimental in Drosophila. Scientific Reports, 6, https://doi.org/10.1038/srep23102
Human Tau (hTau) is a highly soluble and natively unfolded protein that binds to microtubules within neurons. Its dysfunction and aggregation into insoluble paired helical fil...
Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila
Journal Article
Scholes, H. M., Cryar, A., Kerr, F., Sutherland, D., Gethings, L. A., Vissers, J. P. C., …Thalassinos, K. (2020)
Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-74748-9
Alzheimer’s disease (AD), the most prevalent form of dementia, is a progressive and devastating neurodegenerative condition for which there are no effective treatments. Unders...
Building a Systematic Online Living Evidence Summary of COVID-19 Research
Journal Article
Hair, K., Sena, E. S., Wilson, E., Currie, G., Macleod, M., Bahor, Z., …Drury, B. (in press)
Building a Systematic Online Living Evidence Summary of COVID-19 Research. Journal of the European Association for Health Information and Libraries, 17(2), 21-26. https://doi.org/10.32384/jeahil17465
Throughout the global coronavirus pandemic, we have seen an unprecedented volume of COVID-19 researchpublications. This vast body of evidence continues to grow, making it diff...
Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity
Journal Article
Niccoli, T., Kerr, F., Snoeren, I., Fabian, D., Aleyakpo, B., Ivanov, D., …Partridge, L. (2021)
Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity. Brain Communications, 3(2), https://doi.org/10.1093/braincomms/fcab053
Accumulation of amyloid beta peptides is thought to initiate the pathogenesis of Alzheimer’s disease. However, the precise mechanisms mediating their neurotoxicity are unclear...
PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3
Journal Article
Kerr, F., Rickle, A., Nayeem, N., Brandner, S., Cowburn, R. F., & Lovestone, S. (2006)
PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3. FEBS Letters, 580(13), 3121-3128. https://doi.org/10.1016/j.febslet.2006.04.064
Deregulation of PTEN/Akt signalling has been recently implicated in the pathogenesis of Alzheimer's disease (AD), but the effects on the molecular processes underlying AD path...
Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models
Journal Article
Kerr, F., Bjedov, I., & Sofola-Adesakin, O. (2018)
Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models. Frontiers in Molecular Neuroscience, 11, https://doi.org/10.3389/fnmol.2018.00297
Lithium has long been used for the treatment of psychiatric disorders, due to its robust beneficial effect as a mood stabilizing drug. Lithium’s effectiveness for improving ne...
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
Journal Article
Killick, R., Scales, G., Leroy, K., Causevic, M., Hooper, C., Irvine, E. E., …Lovestone, S. (2009)
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. Biochemical and Biophysical Research Communications, 386(1), 257-262. https://doi.org/10.1016/j.bbrc.2009.06.032
As impaired insulin signalling (IIS) is a risk factor for Alzheimer's disease we crossed mice (Tg2576) over-expressing human amyloid precursor protein (APP), with insulin rece...
Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease
Journal Article
Hye, A., Kerr, F., Archer, N., Foy, C., Poppe, M., Brown, R., …Lovestone, S. (2004)
Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease. Neuroscience Letters, 373(1), 1-4. https://doi.org/10.1016/j.neulet.2004.10.031
Alzheimer's disease (AD) is a disorder without a molecular marker in peripheral tissues or a disease modifying treatment. As increasing evidence has suggested a role for glyco...
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
Journal Article
Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010)
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster. Cell Metabolism, 11(1), 35-46. https://doi.org/10.1016/j.cmet.2009.11.010
The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms includi...