The Pancreas Is Altered by In Utero Androgen Exposure: Implications for Clinical Conditions Such as Polycystic Ovary Syndrome (PCOS)
Journal Article
Franks, S., Rae, M. T., Grace, C., Hogg, K., Wilson, L. M., McHaffie, S. L., …Duncan, C. (2013)
The Pancreas Is Altered by In Utero Androgen Exposure: Implications for Clinical Conditions Such as Polycystic Ovary Syndrome (PCOS). PLOS ONE, 8(2), https://doi.org/10.1371/journal.pone.0056263
Using an ovine model of polycystic ovary syndrome (PCOS), (pregnant ewes injected with testosterone propionate (TP) (100 mg twice weekly) from day (d)62 to d102 of d147 gestat...
Cortisol Inactivation by 11β-Hydroxysteroid dehydrogenase-2 May Enhance Endometrial Angiogenesis via Reduced Thrombospondin-1 in Heavy Menstruation
Journal Article
Rae, M. T., Mohamad, A., Price, D., Hadoke, P. W. F., Walker, B. R., Mason, J. I., …Critchley, H. O. D. (2009)
Cortisol Inactivation by 11β-Hydroxysteroid dehydrogenase-2 May Enhance Endometrial Angiogenesis via Reduced Thrombospondin-1 in Heavy Menstruation. Journal of Clinical Endocrinology and Metabolism, 94, 1443-1450. https://doi.org/10.1210/jc.2008-1879
Context: Heavy menstrual bleeding (HMB; menorrhagia) impairs quality of life for women and requires medication or surgery. Because glucocorticoids inhibit angiogenesis in othe...
Anti-inflammatory steroid signalling in the human peritoneum
Journal Article
Fegan, K. S., Rae, M. T., Critchley, H. O. D., & Hillier, S. G. (2008)
Anti-inflammatory steroid signalling in the human peritoneum. Journal of Endocrinology, 196, 369-376. https://doi.org/10.1677/JOE-07-0419
Peritoneal surface epithelial (PSE) cells participate in adhesion formation following inflammatory injury yet adjacent ovarian SE (OSE) cells regenerate without scarification ...
Excess Androgens in Utero Alters Fetal Testis Development.
Journal Article
Connolly, F., Rae, M. T., Bittner, L., Hogg, K., McNeilly, A. S., & Duncan, W. C. (2013)
Excess Androgens in Utero Alters Fetal Testis Development. Endocrinology, 154, 1921-1933. https://doi.org/10.1210/en.2012-2153
Prenatal androgenization induces a polycystic ovary syndrome-like phenotype in adult female offspring, which is associated with alterations that can be detected in the fetal o...
Thyroid hormone signaling in human ovarian surface epithelial cells.
Journal Article
Rae, M. T., Gubbay, O., NaKostogiannou, A., Price, D., Critchley, H. O. D. & Hillier, S. G. (2007)
Thyroid hormone signaling in human ovarian surface epithelial cells. Journal of Clinical Endocrinology and Metabolism. 92, 322-327. doi:10.1210/jc.2006-1522. ISSN 0021-972X
Ovarian surface epithelial (OSE) cells express multiple nuclear hormone receptor genes, including those encoding thyroid hormone and estrogen receptors (TR and ER, respectivel...
The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following
Conference Proceeding
Baudel, M., Rae, M., Fraser, J., & Poole, A. (2017)
The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following. In Brain and Neuroscience: BNA 2017 Festival of Neuroscience: Abstract Book
Stroke is one of the major causes of death and disability worldwide. The harm caused by the interruption of blood flow to the brain unfolds in the subsequent hours and days, s...