MAPK Activation Is Essential for Waddlia chondrophila Induced CXCL8 Expression in Human Epithelial Cells
Journal Article
Storrie, S., Longbottom, D., Barlow, P. G., & Wheelhouse, N. (2016)
MAPK Activation Is Essential for Waddlia chondrophila Induced CXCL8 Expression in Human Epithelial Cells. PLOS ONE, 11(3), https://doi.org/10.1371/journal.pone.0152193
Background
Waddlia chondrophila (W. chondrophila) is an emerging agent of respiratory and reproductive disease in humans and cattle. The organism is a member of the order Chla...
Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages.
Journal Article
Barlow, P. G., Clouter-Baker, A., Donaldson, K., MacCallum, J., & Stone, V. (2005)
Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages. Particle and fibre toxicology, 2(1), 11-24. https://doi.org/10.1186/1743-8977-2-11
Background - Alveolar macrophages are a key cell in dealing with particles deposited in the lungs and in determining the subsequent response to that particle exposure. Nanopar...
Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation
Journal Article
Wilson, M. R., Foucaud, L., Barlow, P. G., Hutchison, G. R., Sales, J., Simpson, R. J., & Stone, V. (2007)
Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation. Toxicology and Applied Pharmacology, 225(1), 80-89. https://doi.org/10.1016/j.taap.2007.07.012
Particulate air pollution (PM10) consists of a mixture of components, including nanoparticles and metals. Studies from our laboratory have demonstrated that transition metals ...
Improved protection against avian influenza H5N1 virus by a single vaccination with virus-like particles in skin using microneedles
Journal Article
Song, J., Kim, Y., Barlow, P. G., Hossain, M. J., Park, K., Donis, R. O., …Kang, S. (2010)
Improved protection against avian influenza H5N1 virus by a single vaccination with virus-like particles in skin using microneedles. Antiviral Research, 88(2), 244-247. https://doi.org/10.1016/j.antiviral.2010.09.001
To develop a more effective vaccination method against H5N1 virus, we investigated the immunogenicity and protective efficacy after skin vaccination using microneedles coated ...
NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy
Journal Article
Fox, S., Wilkinson, T. S., Wheatley, P. S., Xiao, B., Morris, R. E., Sutherland, A., …Rossi, A. G. (2010)
NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy. Acta biomaterialia, 6(4), (1515-1521). doi:10.1016/j.actbio.2009.10.038. ISSN 1742-7061
Nitric oxide (NO) is important for the regulation of a number of diverse biological processes, including vascular tone, neurotransmission, inflammatory cell responsiveness, de...
Antiviral host defence peptides.
Book Chapter
Sousa, F. H., Casanova, V., Stevens, C., & Barlow, P. G. (2016)
Antiviral host defence peptides. In R. M. Epand (Ed.), Host Defense Peptides and Their Potential as Therapeutic Agents, 57-94. Springer Verlag. https://doi.org/10.1007/978-3-319-32949-9_3
The on going global mortality and morbidity associated with viral pathogens highlights the need for the continued development of effective, novel antiviral molecules. The anti...
Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37
Journal Article
Barlow, P. G., Svoboda, P., Mackellar, A., Nash, A. A., York, I. A., Pohl, J., …Donis, R. O. (2011)
Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37. PLOS ONE, 6(10), https://doi.org/10.1371/journal.pone.0025333
The extensive world-wide morbidity and mortality caused by influenza A viruses highlights the need for new insights into the host immune response and novel treatment approache...
Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages
Journal Article
Li, H., Barlow, P. G., Bylund, J., Mackellar, A., Björstad, Å., Conlon, J., …Davidson, D. J. (2009)
Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages. Journal of Leukocyte Biology, 86(4), 891-902. https://doi.org/10.1189/jlb.0209050
Cathelicidins are CHDP with essential roles in innate host defense but also more recently associated with the pathogenesis of certain chronic diseases. These peptides have mic...
A Candidate H1N1 Pandemic Influenza Vaccine Elicits Protective Immunity in Mice
Journal Article
Steitz, J., Barlow, P. G., Hossain, J., Kim, E., Okada, K., Kenniston, T., …Gambotto, A. (2010)
A Candidate H1N1 Pandemic Influenza Vaccine Elicits Protective Immunity in Mice. PLOS ONE, 5(5), https://doi.org/10.1371/journal.pone.0010492
Background
In 2009 a new pandemic disease appeared and spread globally. The recent emergence of the pandemic influenza virus H1N1 first isolated in Mexico and USA raised conce...
Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration
Journal Article
Barlow, P., Donaldson, K., MacCallum, J., Clouter, A., & Stone, V. (2005)
Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration. Toxicology Letters, 155(3), 397-401. https://doi.org/10.1016/j.toxlet.2004.11.006
Objective:
To assess whether fine and ultrafine particles (nanoparticles) have the capacity to activate factors in serum that would induce macrophage migration. This is a mode...