Immune Response of Elite Enduro Racers to Laboratory and Racing Environments: The Influence of Training Impulse and Vibration
Journal Article
Kirkwood, L., Ingram-Sills, L., Taylor, M. D., Malone, E., & Florida-James, G. (2021)
Immune Response of Elite Enduro Racers to Laboratory and Racing Environments: The Influence of Training Impulse and Vibration. International Journal of Environmental Research and Public Health, 18(9), https://doi.org/10.3390/ijerph18094603
Introduction: Understanding the sport-specific immune response elicited during both training and competition is imperative to maximise athlete health and performance. Despite ...
Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men
Journal Article
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., …Florida-James, G. D. (2018)
Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017
Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, p...
Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials
Journal Article
Martin, S., de Haan, L., Miro Estruch, I., Eder, K. M., Marzi, A., Schnekenburger, J., …Bouwmeester, H. (2022)
Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials. Frontiers in Toxicology, 4, Article 974429. https://doi.org/10.3389/ftox.2022.974429
Engineered nanomaterials have been found to induce oxidative stress. Cellular oxidative stress, in turn, can result in the induction of antioxidant and detoxification enzymes ...
Physiological characteristics and performance in elite enduro mountain biking
Journal Article
Kirkwood, L., Ingram, L., Cunningham, J., Malone, E., & Florida-James, G. (2017)
Physiological characteristics and performance in elite enduro mountain biking. Journal of Science and Cycling, 6(2), 13-21. https://doi.org/10.28985/171231.jsc.09
Enduro mountain bike racing is composed of several timed predominantly downhill race stages linked by time restricted, non-competitive transition stages. This study aimed to ...
The Influence of Age, and Cardiorespiratory Fitness on Circulating Angiogenic T Cells and CXCR4 expression
Presentation / Conference
Ross, M., Malone, E., Simpson, R., & Florida-James., G. (2015, May)
The Influence of Age, and Cardiorespiratory Fitness on Circulating Angiogenic T Cells and CXCR4 expression. Poster presented at American College of Sports Medicine (ACSM) Annual Congress, Boston
Aging is associated with endothelial dysfunction, reduced angiogenic capabilities, and an increase in arterial stiffness. Regular exercise is known to offset the age-related d...
Can we enable students to reach their potential through engaging with feedback – a feedback pathway?
Presentation / Conference
Malone, E., & MacNab, A. (2015, January)
Can we enable students to reach their potential through engaging with feedback – a feedback pathway?. Presented at The Teaching Fellows Conference, Edinburgh Napier University, Edinburgh
In response to our experience and supporting evidence [1] that students may not engage with, understand or use their feedback, we have created and introduced a ’feedback pathw...
Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise
Journal Article
Florida-James, G. D., Ingram, L. A., Simpson, R. J., Malone, E., & Florida-James, G. (2015)
Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise. Brain, Behavior, and Immunity, 47, 100-108. https://doi.org/10.1016/j.bbi.2014.12.018
Sleep disruption and deprivation are common in contemporary society and have been linked with poor health, decreased job performance and increased life-stress. The rapid redep...
Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system.
Presentation / Conference
Malone, E., Ross, B., Rae, M., Bouwmeester, H., Gosens, I., Cassee, F., …Hutchison, G. (2016, September)
Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. Poster presented at 11th International Particle Toxicology Conference, Singapore
The introduction of engineered nanomaterials (ENM) to new materials and products requires informed risk
assessment. The altered physico-chemical properties of ENM mean traditi...
Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men
Journal Article
Ross, M., Ingram, L., Taylor, G., Malone, E., Simpson, R. J., West, D., & Florida-James, G. (2018)
Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men. Physiological Reports, 6(12), 1-11. https://doi.org/10.14814/phy2.13697
Aging is associated with elevated cardiovascular disease risk. As a result of aging, endothelial dysfunction develops, partly due to a reduction in vascular regenerative abili...
Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo.
Journal Article
Taylor, M. D., LeGoff, L., Harris, A., Malone, E. M., Allen, J. E., & Maizels, R. M. (2005)
Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. Journal of Immunology, 174, 4924-4933
Human filarial parasites cause chronic infection associated with long-term down-regulation of the host’s immune response. We show here that CD4+ T cell regulation is the main ...