P214 NMDA receptor signalling in human osteoarthritic chondrocytes.
Journal Article
Ramage, L., Hardingham, G., & Salter, D. (2007)
P214 NMDA receptor signalling in human osteoarthritic chondrocytes. Osteoarthritis and Cartilage, 15, B142. https://doi.org/10.1016/s1063-4584%2807%2961569-6
Purpose: Human OA chondrocytes are known to express several subunits of the NMDA receptor (NMDAR), a neuronal signalling molecule. This study analyses downstream activation ev...
NMDA receptor expression and activity in osteoarthritic human articular chondrocytes
Journal Article
Ramage, L., Martel, M., Hardingham, G. E., & Salter, D. M. (2008)
NMDA receptor expression and activity in osteoarthritic human articular chondrocytes. Osteoarthritis and Cartilage, 16(12), 1576-1584. https://doi.org/10.1016/j.joca.2008.04.023
Objective: Classical neuronal signalling molecules such as substance P and glutamate have been identified in cartilage and have roles in
regulation of chondrocyte function. Th...
Wavelet analysis of the ECG: A review
Journal Article
Addison, P. (2005)
Wavelet analysis of the ECG: A review. Physiological Measurement, 26(5), 155-199. https://doi.org/10.1088/0967-3334/26/5/R01
The wavelet transform has emerged over recent years as a powerful time–frequency analysis and signal coding tool favoured for the interrogation of complex nonstationary signal...
Proteolysis-inducing factor core peptide mediates dermcidin-induced proliferation of hepatic cells through multiple signalling networks
Journal Article
Lowrie, A. G., Dickinson, P., Wheelhouse, N., Stewart, G. D., Ross, A. J., Forster, T., & Ross, J. A. (2011)
Proteolysis-inducing factor core peptide mediates dermcidin-induced proliferation of hepatic cells through multiple signalling networks. International Journal of Oncology, 39(3), 709-18. https://doi.org/10.3892/ijo.2011.1064
Dermcidin is a candidate oncogene capable of increasing the number of cultured neuronal, breast cancer and prostate cancer cells and improving the survival of hepatic c...
Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity
Journal Article
Fraser, J. A., & Hupp, T. R. (2007)
Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity. Biochemistry, 46(10), 2655-2673. https://doi.org/10.1021/bi061562j
Dissection of signal transduction pathways has been advanced by classic genetic approaches including targeted gene deletion and siRNA-based inhibition of gene product synthesi...
Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression and NF-kB activation.
Journal Article
Duffin, R., Gilmour, P. S., Schins, R. P. F., Clouter, A., Guy, K., Brown, D. M., …Stone, V. (2001)
Aluminium lactate treatment of DQ12 quartz inhibits its ability to cause inflammation, chemokine expression and NF-kB activation. Toxicology and Applied Pharmacology. 176, 10-17. doi:10.1006/taap.2001.9268. ISSN 0041-008X
In 1997, an IARC Working Group classified quartz (crystalline silica) as a Group 1 lung carcinogen, but only in some industries, i.e., the quartz hazard is a variable entity. ...
P186 Expression of functional NMDA receptors in human OA chondrocytes
Journal Article
Ramage, L., Martel, M., Hardingham, G., & Salter, D. (2007)
P186 Expression of functional NMDA receptors in human OA chondrocytes. Osteoarthritis and Cartilage, 14(Supp. B), S108. https://doi.org/10.1016/s1063-4584%2807%2960638-4
Purpose: Classical neuronal signalling molecules such as substance P and glutamate have been identified in cartilage and are being shown to have roles in regulation of chondro...
Chondrogenic ATDC5 cells: An optimised model for rapid and physiological matrix mineralisation
Journal Article
Newton, P. T., Staines, K. .. . A., Spevak, L., Boskey, A. L., Teixeira, C. C., Macrae, V. E., …Farquharson, C. (2012)
Chondrogenic ATDC5 cells: An optimised model for rapid and physiological matrix mineralisation. International Journal of Molecular Medicine, 30(5), 1187-1193. https://doi.org/10.3892/ijmm.2012.1114
The development of chondrogenic cell lines has led to major advances in the understanding of how chondrocyte differentiation is regulated, and has uncovered many signalling pa...
Thyroid hormone signaling in human ovarian surface epithelial cells.
Journal Article
Rae, M. T., Gubbay, O., NaKostogiannou, A., Price, D., Critchley, H. O. D. & Hillier, S. G. (2007)
Thyroid hormone signaling in human ovarian surface epithelial cells. Journal of Clinical Endocrinology and Metabolism. 92, 322-327. doi:10.1210/jc.2006-1522. ISSN 0021-972X
Ovarian surface epithelial (OSE) cells express multiple nuclear hormone receptor genes, including those encoding thyroid hormone and estrogen receptors (TR and ER, respectivel...
Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling
Journal Article
Staines, K. A., Zhu, D., Farquharson, C., & MacRae, V. E. (2014)
Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling. Journal of Bone and Mineral Metabolism, 32(3), 240-251. https://doi.org/10.1007/s00774-013-0493-2
Bone mineralization is a carefully orchestrated process, regulated by a number of promoters and inhibitors that function to ensure effective hydroxyapatite formation. Here we ...