Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study
Journal Article
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (2019)
Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), https://doi.org/10.1186/s12889-019-7313-0
Background
Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital...
The role of infection in miscarriage
Journal Article
Giakoumelou, S., Wheelhouse, N., Cuschieri, K., Entrican, G., Howie, S. E., & Horne, A. W. (2016)
The role of infection in miscarriage. Human Reproduction Update, 22(1), 116-133. https://doi.org/10.1093/humupd/dmv041
BACKGROUND: Miscarriage is the spontaneous loss of a pregnancy before 12 weeks (early miscarriage) or from 12 to 24 weeks (late miscarriage) of gestation. Miscarriage occurs i...
Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFkappaB activation resulting in a microenvironment predisposed to ectopic pregnancy
Journal Article
Shaw, J. L. V., Wills, G. S., Lee, K., Horner, P. J., McClure, M. O., Abrahams, V. M., …Horne, A. W. (2011)
Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFkappaB activation resulting in a microenvironment predisposed to ectopic pregnancy. American Journal of Pathology, 178(1), 253-60. https://doi.org/10.1016/j.ajpath.2010.11.019
Chlamydia trachomatis and smoking are major risk factors for tubal ectopic pregnancy (EP), but the underlying mechanisms of these associations are not completely understood. F...
Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection
Journal Article
King, A. E., Wheelhouse, N., Cameron, S., McDonald, S. E., Lee, K., Entrican, G., …Horne, A. W. (2009)
Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection. Human Reproduction, 24(3), 679-686. https://doi.org/10.1093/humrep/den452
BACKGROUND: Secretory leukocyte protease inhibitor (SLPI) and elafin are anti-protease and anti-microbial molecules with a role in innate immune defence. They have been demons...
Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment
Journal Article
Ahmad, S. F., Brown, J. K., Campbell, L. L., Koscielniak, M., Oliver, C., Wheelhouse, N., …Horne, A. W. (2018)
Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment. EBioMedicine, 29, 159-165. https://doi.org/10.1016/j.ebiom.2018.02.020
Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo...
Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease
Journal Article
Turin, L., Surini, S., Wheelhouse, N., & Silvia Rocchi, M. (2022)
Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease. Veterinary Research, 53(1), Article 37. https://doi.org/10.1186/s13567-022-01052-x
Environmental transmission of Chlamydia abortus as a result of enzootic disease or disease outbreaks and the threats posed by this pathogen has been previously reported, howev...
Endemicity of Coxiella burnetii infection among people and their livestock in pastoral communities in northern Kenya
Journal Article
Muema, J., Nyamai, M., Wheelhouse, N., Njuguna, J., Jost, C., Oyugi, J., …Thumbi, S. (2022)
Endemicity of Coxiella burnetii infection among people and their livestock in pastoral communities in northern Kenya. Heliyon, 8(10), Article e11133. https://doi.org/10.1016/j.heliyon.2022.e11133
Background
Coxiella burnetti can be transmitted to humans primarily through inhaling contaminated droplets released from infected animals or consumption of contaminated dairy ...
Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube
Journal Article
Duncan, W. C., McDonald, S. E., Dickinson, R. E., Shaw, J. L. V., Lourenco, P. C., Wheelhouse, N., …Horne, A. W. (2010)
Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube. Molecular Human Reproduction, 16, 950-959. https://doi.org/10.1093/molehr/gaq055
We investigated whether the repulsive SLIT/ROBO pathway is expressed in the endometrium and is negatively regulated during implantation. We also examined whether deficient exp...