Kasia Siemienowicz

kasia siemienowicz

Dr Kasia Siemienowicz BSc (Hons) MSc PhD AFHEA

Research Fellow

Biography

I am a Research Fellow at Edinburgh Napier University. The current project I work on is an extensive, collaborative research aiming to determine the long-term consequences of early life steroid signalling perturbations and their impact on postnatal health, led by prof. Mick Rae.
In 2011 I graduated with a first-class degree in Biomedical Science from Edinburgh Napier University and in 2012 I was awarded MSc by Research with Distinction in Reproductive Sciences at The University of Edinburgh. In 2017 I completed my PhD training at the Centre for Reproductive Health in The Queen's Medical Research Institute at The University of Edinburgh. My thesis title: Fetal programming of adult disease: Causes and consequences of metabolic dysregulation in an ovine model of PCOS.
During my academic years, I have spent time studying various aspects of reproductive biology, endocrinology, metabolism and the effects of prenatal programming of adult disease. In 2016, I was awarded Young Investigator Award by the European Society of Endocrinology. My life ambition is to combine my passion for health, enthusiasm for research and a strong interest in reproductive biology, metabolism and endocrinology to make a direct impact on improving people's lives.

Themes

Research Areas

Esteem

Conference Activity

  • Poster presentation: Prenatal androgen exposure disturbs female liver phenotype in an ovine model of PCOS. Fertility 2020 Conference.
  • Poster Presentation: Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life. European Congress of Endocrinology.
  • Poster Presentation: Decreased hepatic detoxification potential in males - consequences of androgen excess in fetal life. European Congress of Endocrinology.
  • Poster Presentation: Fetal androgen excess determines adult male health via hepatic dysfunction and dyslipidaemia. Mechanisms and Evolution of Integrational Change Conference
  • Oral Presentation: Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an Ovine Model of Polycystic Ovary Syndrome (PCOS). Society of Reproduction and Fertility.
  • Oral Presentation: Impaired adipose function in PCOS – evidence that the primary abnormalities are in subcutaneous rather than visceral fat. European Congress of Endocrinology.
  • Chair of the SRF Annual Conference, Oral Communications
  • Oral Presentation: Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure. Society of Reproduction and Fertility.
  • Poster Presentation: Altered adipocytes in an Ovine Model of Polycystic Ovary Syndrome (PCOS). Society for Endocrinology.
  • Oral Presentation: Potential role of FGF21 in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome. Society of Reproduction and Fertility.
  • Poster Presentation: The pathophysiology of increased hepatic IGF-1 expression in an ovine model of polycystic ovary syndrome. European Society of Endocrinology.

 

Fellowships and Awards

  • European Society of Endocrinology Science Meeting Grant
  • Young Investigator Award, European Society of Endocrinology
  • SRF Student Prize, Society for Reproduction and Fertility
  • Science Meeting Grant, European Society of Endocrinology
  • BES Grant, Society for Endocrinology

 

Membership of Professional Body

  • Associate Fellow of Higher Education Academy
  • Member of Society for Endocrinology
  • Member of European Society of Endocrinology
  • Member of Society for Reproduction and Fertility

 

Date


10 results

Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS)

Journal Article
Siemienowicz, K., Rae, M. T., Howells, F., Anderson, C., Nicol, L. M., Franks, S., & Duncan, W. C. (in press)
Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS). iScience, https://doi.org/10.1016/j.isci.2020.101164
Women with polycystic ovary syndrome (PCOS) are more likely to be obese and have difficulty in losing weight. They demonstrate an obesity-independent deficit in adaptive energ...

Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life

Journal Article
Siemienowicz, K., Filis, P., Shaw, S., Douglas, A., Thomas, J., Howie, F., …Rae, M. (2019)
Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life. Endocrine abstracts, 63, https://doi.org/10.1530/endoabs.63.P669
Introduction: Adult male offspring of women with PCOS have increased dyslipidaemia, characterised by elevated triglycerides (TG), increased total and LDL-cholesterol (LDL-C), ...

Fetal androgen exposure is a determinant of adult male metabolic health

Journal Article
Siemienowicz, K. J., Filis, P., Shaw, S., Douglas, A., Thomas, J., Mulroy, S., …Rae, M. T. (2019)
Fetal androgen exposure is a determinant of adult male metabolic health. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-56790-4
Androgen signalling is a critical driver of male development. Fetal steroid signalling can be dysregulated by a range of environmental insults and clinical conditions. We hypo...

Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS)

Presentation / Conference
Siemienowicz, K., Coukan, F., Lerner, A., Franks, S., Rae, M., & Duncan, C. (2016, July)
Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS). Paper presented at Society for Reproduction and Fertility Annual Conference

Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion

Journal Article
Ramaswamy, S., McNeilly, A. S., Rae, M. T., Ramaswamy, S., Grace, C., Mattei, A. A., …Rae, M. T. (2016)
Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion. Scientific Reports, 6(1), https://doi.org/10.1038/srep27408
Exogenous androgenic steroids applied to pregnant sheep programmes a PCOS-like phenotype in female offspring. Via ultrasound guidance we applied steroids directly to ovine fet...

Impaired adipose function in PCOS - evidence that the primary abnormalities are in subcutaneous rather than visceral fat

Presentation / Conference
Siemienowicz, K., Coukan, F., Lerner, A., Franks, S., Rae, M., & Duncan, C. (2016, May)
Impaired adipose function in PCOS - evidence that the primary abnormalities are in subcutaneous rather than visceral fat. Paper presented at European Congress of Endocrinology

Altered adipocytes in an ovine model of polycystic ovary syndrome

Presentation / Conference
Siemienowicz, K., Couckan, F., Lerner, A., Franks, S., Rae, M., & Duncan, C. (2015, November)
Altered adipocytes in an ovine model of polycystic ovary syndrome. Poster presented at Society for Endocrinology BES

Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure

Presentation / Conference
Siemienowicz, K., Rae, M., Lerner, A., Franks, S., & Duncan, C. (2015, July)
Obesity in PCOS: a consequence of prenatally programmed reduced energy expenditure. Paper presented at Society for Reproduction and Fertility Annual Conference
Polycystic ovary syndrome, a common endocrine condition affecting up to 10% of women of reproductive age, is associated with an increased risk of developing insulin resistance...

Potential role of FGF21 in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome

Presentation / Conference
Siemienowicz, K., Rae, M., & Duncan, C. (2014, September)
Potential role of FGF21 in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome. Paper presented at Society for Reproduction and Fertility Annual Conference

The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome

Presentation / Conference
Siemienowicz, K., Boswell, L., Carr, D., Mina, T., Connolly, F., Rae, M., & Duncan, C. (2014, May)
The pathophysiology of increased hepatic IGF1 expression in an ovine model of polycystic ovary syndrome. Poster presented at 16th European Congress of Endocrinology
Exposure of pregnant sheep to increased concentrations of testosterone during midgestation results in a PCOS-like condition in the female offspring that includes increased hep...