Lesley Young

Lesley Young

Dr Lesley Young

Senior Technician

Date


3 results

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations

Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018)
Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), https://doi.org/10.1038/s41598-018-25854-2
Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrop...

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos

Journal Article
Boyles, M. S., Young, L., Brown, D. M., MacCalman, L., Cowie, H., Moisala, A., …Stone, V. (2015)
Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos. Toxicology in Vitro, 29(7), 1513-1528. https://doi.org/10.1016/j.tiv.2015.06.012
The potential toxicity of carbon nanotubes (CNTs) has been compared to pathogenic fibres such as asbestos. It is important to test this hypothesis to ascertain safe methods fo...

Targeting an MMP-9-activated prodrug to multiple myeloma diseased bone marrow: a proof of principle in the 5T33MM mouse model.

Journal Article
Van Valckenborgh, E., Mincher, D., Di Salvo, A., Van Riet, I., Young, L., Van Camp, B. & Vanderkerken, K. (2005)
Targeting an MMP-9-activated prodrug to multiple myeloma diseased bone marrow: a proof of principle in the 5T33MM mouse model. Leukemia. 19, 1628 -1633. doi:10.1038/sj.leu.2403866. ISSN 0887-6924
Multiple myeloma (MM) is an incurable B-cell cancer characterised by the monoclonal proliferation of tumour cells in the bone marrow (BM). It has been described that matrix me...

Current Post Grad projects

Previous Post Grad projects