Lorna Proudfoot

Lorna Proudfoot

Dr Lorna Proudfoot

Lecturer

Biography

I graduated from Glasgow University in 1991 from the Department of Biochemistry with a PhD entitled 'Dynamic aspects of the nematode surface'. I then moved on to Dundee University Biochemistry Department for my first post-doctoral research where I studied parasite glycoconjugates with Prof Mike Ferguson and Dr Malcolm McConville. My second post-doc was with Professor Eddy Liew at the Department of Immunology, Glasgow University in 1993 where I investigated the effect of Leishmania parasite glycoconjugates on the innate immune system and production of nitric oxide. In 1996 I became a lecturer here at the School of Applied Sciences.

Themes

Esteem

Advisory panels and expert committees or witness

  • SQA (QAA) National Validation - Chair of the HN Group Award Validation of the HND Applied Biological Sciences, June 2005.

 

Conference/Workshop

  • Nanotox 2010, Edinburgh Napier University

 

External Examining/Validations

  • PhD External Examiner, Edinburgh University Glyn Ball. An evaluation of the Nippostrongylus brasiliensis infection in the rat as a model for the development of subunit vaccines against nematode parasites of ruminants.
  • PhD External Examiner, Glasgow University Claire Roberts. Biophysical properties of the nematode surface.

 

Fellowships and Awards

  • Fellow of the Higher Education Academy

 

Grant Reviewer

  • Reviewer for Research Grants: Medical Research Council, BBSRC, Broad Foundation, SPARC (EPSRC & BBSRC), NWO-nano Technology foundation STW (Netherlands).

 

Invited Speaker

  • Inflammation and Inflammatory Disease, Royal Society of Edinburgh
  • British Society for Parasitology, Edinburgh University Oral presentation in the ‘Immunomodulation by Helminths’ session
  • NanoImpactNet Q-Nano, University College Dublin

 

Public Engagement Activity

  • Edinburgh International Science Festival, April 2011. FluFighters, Discover Science event at the Museum of Scotland

 

Reviewing

  • Reviewer for Research Journals: Immunology, Clinical and Experimental Immunology, Parasite Immunology, Parasitology Research, European Journal of Medicinal Chemistry.

 

Date


23 results

Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration

Journal Article
Findlay, F., Pohl, J., Svoboda, P., Shakamuri, P., McLean, K., Inglis, N. F., …Barlow, P. G. (2017)
Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration. Journal of Immunology, 199(7), 2483-2490. https://doi.org/10.4049/jimmunol.1700706
Host defense peptides, also known as antimicrobial peptides, are key elements of innate host defense. One host defense peptide with well-characterized antimicrobial activity i...

Cathelicidins display conserved direct antiviral activity towards rhinovirus.

Journal Article
Sousa, F. H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., …Barlow, P. G. (2017)
Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides, 95, 76-83. https://doi.org/10.1016/j.peptides.2017.07.013
Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised ind...

Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections

Presentation / Conference
Oluwadare, E., Rehan, A., Ding, Y., Turnbull, A., Malone, E., Mincher, D., & Proudfoot, L. (2016, September)
Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections. Poster presented at Molecular & Cellular Biology of Helminth Parasites X, Hydra, Greece
Anthelmintic resistance and the shortage of new drugs represent an urgent need for the development of novel anti-parasite drugs with effective delivery to the target site. Red...

Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections

Journal Article
Findlay, F., Proudfoot, L., Stevens, C., & Barlow, P. G. (2016)
Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections. Pathogens and Global Health, 110(4-5), 137-147. https://doi.org/10.1080/20477724.2016.1195036
Cationic Host Defense Peptides (HDP, also known as antimicrobial peptides) are crucial components of the innate immune system and possess broad-spectrum antibacterial, antivir...

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos

Journal Article
Boyles, M. S., Young, L., Brown, D. M., MacCalman, L., Cowie, H., Moisala, A., …Stone, V. (2015)
Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos. Toxicology in Vitro, 29(7), 1513-1528. https://doi.org/10.1016/j.tiv.2015.06.012
The potential toxicity of carbon nanotubes (CNTs) has been compared to pathogenic fibres such as asbestos. It is important to test this hypothesis to ascertain safe methods fo...

Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status

Journal Article
Prach, M., Stone, V., & Proudfoot, L. (2012)
Zinc oxide nanoparticles and monocytes: Impact of size, charge and solubility on activation status. Toxicology and Applied Pharmacology, 266(1), 19-26. https://doi.org/10.1016/j.taap.2012.10.020
Zinc oxide (ZnO) particle induced cytotoxicity was dependent on size, charge and solubility, factors which at sublethal concentrations may influence the activation of the huma...

Nanoparticles and Neutrophil Activation

Presentation / Conference
Dickson, C., Prach, M., Fraser, J., Ingram, L., Barlow, P., Hutchison, G., …Malone, E. (2012, February)
Nanoparticles and Neutrophil Activation. Presented at NanoImpactNet-QNANO conference - European Network on the Health and Environmental Impact of Nanomaterials, Dublin, Ireland
Neutrophils, the rapid responders of the innate immune system, are central to the initial immune responses of a host to foreign particles. Circulating in the blood, they are t...

The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line.

Journal Article
Clift, M. J. D., Rothen-Rutishauer, B., Brown, D. M., Duffin, R., Donaldson, K., Proudfoot, L., …Stone, V. (2008)
The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line. Toxicology and applied pharmacology, 232, 418-427. https://doi.org/10.1016/j.taap.2008.06.009
This study investigated the uptake, kinetics and cellular distribution of different surface coated quantum dots (QDs) before relating this to their toxicity. J774.A1 cells wer...

Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation

Journal Article
Zhao, M., Brown, D. M., MacCallum, J., & Proudfoot, L. (2008)
Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation. Parasite Immunology, 31(1), 50-56. https://doi.org/10.1111/j.1365-3024.2008.01073.x
The anti-inflammatory properties of parasitic helminths have been largely linked to their excretory-secretory (ES) products. Some studies have noted a lack of TNF-alpha produc...

Accute toxicity of linear alkylbenzene to Caenorhabditis elegans Maupas, 1900 in soil.

Journal Article
Johnson, S. J., Castan, M., Proudfoot, L., Barry, D. A. & Christofi, N. (2007)
Accute toxicity of linear alkylbenzene to Caenorhabditis elegans Maupas, 1900 in soil. Bulletin of Environmental Contamination and Toxicology. 79, 41-44. doi:10.1007/s00128-007-9195-6. ISSN 0007-4861
Linear alkybenzene (LAB) is a light non-aqueous phase liquid (LNAPL) whose primary use is as a precursor in the manufacture of linear alkylbenzene sulphonate (LAS) detergents....

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