Mick Rae

Mick Rae

Prof Mick Rae

Professor

Biography

Having begun my career at what was then Napier College of Commerce and Technology, then became Napier Polytechnic, I graduated in 1991 with an honours degree in Biological Sciences. This fostered an interest/obsession in the research field of reproduction, which I was fortunate to be able to pursue in the University of Edinburgh medical School, leading to the award of PhD in 1995. I then spent two years in the University of Kent working on projects examining novel cancer imaging techniques, which hugely boosted my laboratory skills, prior to returning to the field of reproductive sciences in 1997 at what is now the James Hutton Institute in Aberdeen. I returned to the University of Edinburgh in 2001, and remained there, working on ovarian function and cancer, until my initial appointment as a lecturer in Edinburgh Napier University. Becoming Reader in Reproductive Biology in 2012, I have continued to pursue my reproductive research interests, focusing upon the influence the prenatal environment has upon lifelong health – we are living longer, and ‘healthspan’ has to keep pace with lifespan if we are to maximise our quality of life, hence ensuring that we begin our lives with the best possible health opportunities for life is something I am very keen to contribute to.
In my spare time, I attempt to keep a classic car on the road, and enjoy fishing for wild brown trout all over Scotland.

Themes

Research Areas

Esteem

Advisory panels and expert committees or witness

  • Society for Reproduction and Fertility, Council member 2011-2015

 

Conference Activity

  • Lead organiser of National Ovarian Workshop 2005
  • Local organiser of the 2nd World Congress of Reproductive Biology, Edinburgh International Conference Centre, 2014
  • Invited chair: Royal Society of Edinburgh, Special conference in recognition of scientific contributions of Professor AS McNeilly, Ovary session 2014
  • Invited chair, University of Oxford SRF annual conference 2015 – session: ‘oocytes’
  • Invited chair: University of Cambridge SRF annual conference 2014, session: plenary opening

 

Editorial Activity

  • Editorial board member

 

External Examining/Validations

  • External examination of PhD University of Southampton
  • PhD external examiner: University of Aberdeen, University of Nottingham
  • University of Nottingham Veterinary School, external examiner for 2nd year of veterinary studies

 

Fellowships and Awards

  • Honorary Fellow in the Deanery of Clinical Sciences, in the College of Medicine and Veterinary Medicine, The University of Edinburgh

 

Invited Speaker

  • Prenatal steroids programme metabolic dysfunction in sheep
  • How reproduction works (more or less)
  • Invited speaker at INRA (Paris)
  • Invited speaker at Murdoch University
  • Invited speaker at Perth Zoo, Australia
  • Invited speaker at SRUC 2014 – ‘how biomedical and agricultural scientists can benefit from each other more’.
  • Invited speaker University of Edinburgh: ‘How to build an academic career’

 

Reviewing

  • Ad hoc reviewer of scientific articles for numerous (>3) international journals

 

Date


60 results

Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells

Journal Article
Brown, M., Rae, M., & Wheelhouse, N. (2021)
Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells. Reproduction and Fertility, 2(1), 9-11. https://doi.org/10.1530/RAF-20-0069
Chlamydia trachomatis is the most commonly diagnosed sexually transmitted infection in the UK, with over 200,000 positive diagnoses annually. The infection is thought to cause...

Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome

Journal Article
Siemienowicz, K. J., Furmanska, K., Filis, P., Talia, C., Thomas, J., Fowler, P. A., …Colin Duncan, W. (2021)
Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome. Molecular and Cellular Endocrinology, 525, https://doi.org/10.1016/j.mce.2021.111196
Polycystic ovary syndrome (PCOS), affecting over 10% of women, is associated with insulin resistance, obesity, dyslipidaemia, fatty liver and adipose tissue dysfunction. Its p...

Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses

Journal Article
Siemienowicz, K. J., Wang, Y., Marečková, M., Nio-Kobayashi, J., Fowler, P. A., Rae, M. T., & Duncan, W. C. (2020)
Early pregnancy maternal progesterone administration alters pituitary and testis function and steroid profile in male fetuses. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-78976-x
Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in...

Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS)

Journal Article
Siemienowicz, K. J., Coukan, F., Franks, S., Rae, M. T., & Colin Duncan, W. (2021)
Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS). Molecular and Cellular Endocrinology, 519, https://doi.org/10.1016/j.mce.2020.111042
Polycystic ovary syndrome (PCOS) affects over 10% of women. Insulin resistance, elevated free fatty acids (FFAs) and increased adiposity are key factors contributing to meta...

Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS)

Journal Article
Siemienowicz, K., Rae, M. T., Howells, F., Anderson, C., Nicol, L. M., Franks, S., & Duncan, W. C. (2020)
Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS). iScience, 23(6), https://doi.org/10.1016/j.isci.2020.101164
Women with polycystic ovary syndrome (PCOS) are more likely to be obese and have difficulty in losing weight. They demonstrate an obesity-independent deficit in adaptive energ...

Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life

Journal Article
Siemienowicz, K., Filis, P., Shaw, S., Douglas, A., Thomas, J., Howie, F., …Rae, M. (2019)
Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life. Endocrine abstracts, 63, https://doi.org/10.1530/endoabs.63.P669
Introduction: Adult male offspring of women with PCOS have increased dyslipidaemia, characterised by elevated triglycerides (TG), increased total and LDL-cholesterol (LDL-C), ...

Fetal androgen exposure is a determinant of adult male metabolic health

Journal Article
Siemienowicz, K. J., Filis, P., Shaw, S., Douglas, A., Thomas, J., Mulroy, S., …Rae, M. T. (2019)
Fetal androgen exposure is a determinant of adult male metabolic health. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-56790-4
Androgen signalling is a critical driver of male development. Fetal steroid signalling can be dysregulated by a range of environmental insults and clinical conditions. We hypo...

Urinary estrogens as a non-invasive biomarker of viable pregnancy in the giant panda (Ailuropoda melanoleuca)

Journal Article
Wilson, K. S., Wauters, J., Valentine, I., McNeilly, A., Girling, S., Li, R., …Duncan, W. C. (2019)
Urinary estrogens as a non-invasive biomarker of viable pregnancy in the giant panda (Ailuropoda melanoleuca). Scientific Reports, 9(1), https://doi.org/10.1038/s41598-019-49288-6
Female giant pandas show complex reproductive traits, being seasonally monoestrus, displaying a variable length embryonic diapause and exhibiting pseudopregnancy. Currently, t...

Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring

Journal Article
Wauters, J., Wilson, K. S., Bouts, T., Valentine, I., Vanderschueren, K., Ververs, C., …Vanhaecke, L. (2018)
Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring. PLOS ONE, 13(7), https://doi.org/10.1371/journal.pone.0201420
Reproductive monitoring for captive breeding in giant pandas is based on behavioural observation and non-invasive hormone analysis. In urine, interpretation of results require...

Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia

Journal Article
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V., & Fraser, J. A. (2017)
Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLOS ONE, 12(10), https://doi.org/10.1371/journal.pone.0185664
Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxyg...

Current Post Grad projects

Previous Post Grad projects

Non-Napier PhD or MSc by Research supervisions

  • Reproductive and metabolic programming by exogenous steroids
  • Optimisation and validation of an in vitro bioassay as a tool for measuring Luteinising Hormone in several species of mammals