Mick Rae

Mick Rae

Prof Mick Rae

Professor

Biography

Having begun my career at what was then Napier College of Commerce and Technology, then became Napier Polytechnic, I graduated in 1991 with an honours degree in Biological Sciences. This fostered an interest/obsession in the research field of reproduction, which I was fortunate to be able to pursue in the University of Edinburgh medical School, leading to the award of PhD in 1995. I then spent two years in the University of Kent working on projects examining novel cancer imaging techniques, which hugely boosted my laboratory skills, prior to returning to the field of reproductive sciences in 1997 at what is now the James Hutton Institute in Aberdeen. I returned to the University of Edinburgh in 2001, and remained there, working on ovarian function and cancer, until my initial appointment as a lecturer in Edinburgh Napier University. Becoming Reader in Reproductive Biology in 2012, I have continued to pursue my reproductive research interests, focusing upon the influence the prenatal environment has upon lifelong health – we are living longer, and ‘healthspan’ has to keep pace with lifespan if we are to maximise our quality of life, hence ensuring that we begin our lives with the best possible health opportunities for life is something I am very keen to contribute to.
In my spare time, I attempt to keep a classic car on the road, and enjoy fishing for wild brown trout all over Scotland.

Themes

Research Areas

Esteem

Advisory panels and expert committees or witness

  • Society for Reproduction and Fertility, Council member 2011-2015

 

Conference Activity

  • Invited chair: Royal Society of Edinburgh, Special conference in recognition of scientific contributions of Professor AS McNeilly, Ovary session 2014
  • Invited chair, University of Oxford SRF annual conference 2015 – session: ‘oocytes’
  • Invited chair: University of Cambridge SRF annual conference 2014, session: plenary opening
  • Lead organiser of National Ovarian Workshop 2005
  • Local organiser of the 2nd World Congress of Reproductive Biology, Edinburgh International Conference Centre, 2014

 

Editorial Activity

  • Editorial board member

 

External Examining/Validations

  • External examination of PhD University of Southampton
  • PhD external examiner: University of Aberdeen, University of Nottingham
  • University of Nottingham Veterinary School, external examiner for 2nd year of veterinary studies

 

Fellowships and Awards

  • Honorary Fellow in the Deanery of Clinical Sciences, in the College of Medicine and Veterinary Medicine, The University of Edinburgh

 

Invited Speaker

  • Prenatal steroids programme metabolic dysfunction in sheep
  • How reproduction works (more or less)
  • Invited speaker at INRA (Paris)
  • Invited speaker at Murdoch University
  • Invited speaker at Perth Zoo, Australia
  • Invited speaker at SRUC 2014 – ‘how biomedical and agricultural scientists can benefit from each other more’.
  • Invited speaker University of Edinburgh: ‘How to build an academic career’

 

Reviewing

  • Ad hoc reviewer of scientific articles for numerous (>3) international journals

 

Date


56 results

Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS)

Journal Article
Siemienowicz, K., Rae, M. T., Howells, F., Anderson, C., Nicol, L. M., Franks, S., & Duncan, W. C. (in press)
Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS). iScience, https://doi.org/10.1016/j.isci.2020.101164
Women with polycystic ovary syndrome (PCOS) are more likely to be obese and have difficulty in losing weight. They demonstrate an obesity-independent deficit in adaptive energ...

Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life

Journal Article
Siemienowicz, K., Filis, P., Shaw, S., Douglas, A., Thomas, J., Howie, F., …Rae, M. (2019)
Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life. Endocrine abstracts, 63, https://doi.org/10.1530/endoabs.63.P669
Introduction: Adult male offspring of women with PCOS have increased dyslipidaemia, characterised by elevated triglycerides (TG), increased total and LDL-cholesterol (LDL-C), ...

Fetal androgen exposure is a determinant of adult male metabolic health

Journal Article
Siemienowicz, K. J., Filis, P., Shaw, S., Douglas, A., Thomas, J., Mulroy, S., …Rae, M. T. (2019)
Fetal androgen exposure is a determinant of adult male metabolic health. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-56790-4
Androgen signalling is a critical driver of male development. Fetal steroid signalling can be dysregulated by a range of environmental insults and clinical conditions. We hypo...

Urinary estrogens as a non-invasive biomarker of viable pregnancy in the giant panda (Ailuropoda melanoleuca)

Journal Article
Wilson, K. S., Wauters, J., Valentine, I., McNeilly, A., Girling, S., Li, R., …Duncan, W. C. (2019)
Urinary estrogens as a non-invasive biomarker of viable pregnancy in the giant panda (Ailuropoda melanoleuca). Scientific Reports, 9(1), https://doi.org/10.1038/s41598-019-49288-6
Female giant pandas show complex reproductive traits, being seasonally monoestrus, displaying a variable length embryonic diapause and exhibiting pseudopregnancy. Currently, t...

Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring

Journal Article
Wauters, J., Wilson, K. S., Bouts, T., Valentine, I., Vanderschueren, K., Ververs, C., …Vanhaecke, L. (2018)
Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring. PLOS ONE, 13(7), https://doi.org/10.1371/journal.pone.0201420
Reproductive monitoring for captive breeding in giant pandas is based on behavioural observation and non-invasive hormone analysis. In urine, interpretation of results require...

Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia

Journal Article
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V., & Fraser, J. A. (2017)
Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLOS ONE, 12(10), https://doi.org/10.1371/journal.pone.0185664
Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxyg...

Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia

Presentation / Conference
Fraser, J., Baudel, M., Rae, M., Darlison, M., & Poole, A. (2017, April)
Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia. Poster presented at British Neuroscience Association - festival of neuroscience 2017
Stroke is a leading cause of death and disability worldwide. Blockage, or occlusion, of cerebral arteries causes irreversible neuronal damage as disrupted blood flow starves n...

The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following

Conference Proceeding
Baudel, M., Rae, M., Fraser, J., & Poole, A. (2017)
The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following. In Brain and Neuroscience: BNA 2017 Festival of Neuroscience: Abstract Book
Stroke is one of the major causes of death and disability worldwide. The harm caused by the interruption of blood flow to the brain unfolds in the subsequent hours and days, s...

Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system.

Presentation / Conference
Malone, E., Ross, B., Rae, M., Bouwmeester, H., Gosens, I., Cassee, F., …Hutchison, G. (2016, September)
Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. Poster presented at 11th International Particle Toxicology Conference, Singapore
The introduction of engineered nanomaterials (ENM) to new materials and products requires informed risk assessment. The altered physico-chemical properties of ENM mean traditi...

Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS)

Presentation / Conference
Siemienowicz, K., Coukan, F., Lerner, A., Franks, S., Rae, M., & Duncan, C. (2016, July)
Exaggerated metabolic changes during puberty precede adult obesity and hyperlipidemia in an ovine model of Polycystic Ovary Syndrome (PCOS). Paper presented at Society for Reproduction and Fertility Annual Conference

Current Post Grad projects

Previous Post Grad projects

Non-Napier PhD or MSc by Research supervisions

  • Reproductive and metabolic programming by exogenous steroids
  • Optimisation and validation of an in vitro bioassay as a tool for measuring Luteinising Hormone in several species of mammals