Mick Rae
Mick Rae

Prof Mick Rae

Professor

Biography

Having begun my career at what was then Napier College of Commerce and Technology, then became Napier Polytechnic, I graduated in 1991 with an honours degree in Biological Sciences. This fostered an interest/obsession in the research field of reproduction, which I was fortunate to be able to pursue in the University of Edinburgh medical School, leading to the award of PhD in 1995. I then spent two years in the University of Kent working on projects examining novel cancer imaging techniques, which hugely boosted my laboratory skills, prior to returning to the field of reproductive sciences in 1997 at what is now the James Hutton Institute in Aberdeen. I returned to the University of Edinburgh in 2001, and remained there, working on ovarian function and cancer, until my initial appointment as a lecturer in Edinburgh Napier University. Becoming Reader in Reproductive Biology in 2012, I have continued to pursue my reproductive research interests, focusing upon the influence the prenatal environment has upon lifelong health – we are living longer, and ‘healthspan’ has to keep pace with lifespan if we are to maximise our quality of life, hence ensuring that we begin our lives with the best possible health opportunities for life is something I am very keen to contribute to.
In my spare time, I attempt to keep a classic car on the road, and enjoy fishing for wild brown trout all over Scotland.

Themes

Research Areas

Esteem

Advisory panels and expert committees or witness

  • Society for Reproduction and Fertility, Council member 2011-2015

 

Conference Organising Activity

  • Lead organiser of National Ovarian Workshop 2005
  • Invited chair, University of Oxford SRF annual conference 2015 – session: ‘oocytes’
  • Invited chair: Royal Society of Edinburgh, Special conference in recognition of scientific contributions of Professor AS McNeilly, Ovary session 2014
  • Invited chair: University of Cambridge SRF annual conference 2014, session: plenary opening
  • Local organiser of the 2nd World Congress of Reproductive Biology, Edinburgh International Conference Centre, 2014

 

Editorial Activity

  • Editorial board member

 

External Examining/Validations

  • External examination of PhD University of Southampton
  • University of Nottingham Veterinary School, external examiner for 2nd year of veterinary studies
  • PhD external examiner: University of Aberdeen, University of Nottingham

 

Fellowships and Awards

  • Honorary Fellow in the Deanery of Clinical Sciences, in the College of Medicine and Veterinary Medicine, The University of Edinburgh

 

Invited Speaker

  • How reproduction works (more or less)
  • Prenatal steroids programme metabolic dysfunction in sheep
  • Invited speaker at Perth Zoo, Australia
  • Invited speaker University of Edinburgh: ‘How to build an academic career’
  • Invited speaker at SRUC 2014 – ‘how biomedical and agricultural scientists can benefit from each other more’.
  • Invited speaker at Murdoch University
  • Invited speaker at INRA (Paris)

 

Reviewing

  • Ad hoc reviewer of scientific articles for numerous (>3) international journals

 

Date


63 results

Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas

Journal Article
Gubbay, O., Guo, W., Rae, M. T., Niven, D., Langdon, S. P., & Hillier, S. G. (2005)
Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas. British Journal of Cancer, 92, 1927-1933. https://doi.org/10.1038/sj.bjc.6602568
Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with in...

Impact of maternal undernutrition and fetal number on glucocorticoid, growth hormone and insulin-like growth factor receptor mRNA abundance in the ovine fetal kidney

Journal Article
Brennan, K. A., Gopalakrishnan, G. S., Kurlak, L., Rhind, S. M., Kyle, C. E., Brooks, A. N., …Symonds, M. E. (2005)
Impact of maternal undernutrition and fetal number on glucocorticoid, growth hormone and insulin-like growth factor receptor mRNA abundance in the ovine fetal kidney. Reproduction, 129, 151-159. https://doi.org/10.1530/rep.1.00229
Epidemiological and animal studies strongly indicate that the environment experienced in utero determines, in part, an individual’s likelihood of developing cardiovascular dis...

Anti-inflammatory and proliferative responses in human and ovine ovarian surface epithelial cells

Journal Article
Gubbay, O., Guo, W., Rae, M. T., Niven, D., Howie, A. F., McNeilly, A. S., …Hillier, S. G. (2004)
Anti-inflammatory and proliferative responses in human and ovine ovarian surface epithelial cells. Reproduction, 128, 607-614. https://doi.org/10.1530/rep.1.00272
The majority of ovarian cancers (>90%) are believed to derive from the ovarian surface epithelium (OSE); a single layer covering the entire surface of the ovary. At ovulation,...

Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis.

Journal Article
Rae, M. T., Niven, D., Ross, A., Forster, T., Lathe, R., Critchley, H. O. D., …Hillier, S. G. (2004)
Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis. Journal of Endocrinology, 183, 19-28. https://doi.org/10.1677/joe.1.05754
The human ovarian surface epithelium (HOSE) is a common site of gynaecological disease including endometriosis and ovarian cancer, probably due to serial injury-repair events ...

Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells

Journal Article
Hillier, S. G., Rae, M. T., Niven, D., Critchley, H. O. D., & Harlow, C. R. (2004)
Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells. Journal of Clinical Endocrinology and Metabolism, 89(9), 4538-4544. https://doi.org/10.1210/jc.2003-032225
The human ovarian surface epithelium (OSE) is subject to serial injury and repair during ovulation, which is a natural inflammatory event. We asked whether there is a compensa...

Programming of adult cardiovascular function after early maternal undernutrition in sheep

Journal Article
Gopalakrishnan, G. S., Gardner, D. S., Rhind, S. M., Rae, M. T., Kyle, C. E., Brooks, A. N., …Symonds, M. E. (2004)
Programming of adult cardiovascular function after early maternal undernutrition in sheep. American journal of physiology: regulatory, integrative and comparative physiology, 287(1), R12-R20. https://doi.org/10.1152/ajpregu.00687.2003
The prenatal nutritional environment influences the subsequent risk of hypertension in adulthood. Animal studies have used, generally, the rat as a model species to illustrate...

Effects of prenatal undernutrition on emotional reactivity and cognitive flexibility in adult sheep

Journal Article
Erhard, H. W., Boissy, A., Rae, M. T., & Rhind, S. M. (2004)
Effects of prenatal undernutrition on emotional reactivity and cognitive flexibility in adult sheep. Behavioural Brain Research, 151(1-2), 25-35. https://doi.org/10.1016/j.bbr.2003.08.003
The experiment reported was designed to test two hypotheses: that prenatal undernutrition (a) increases emotional reactivity and (b) impairs cognitive flexibility in sheep. Th...

Glucocorticoid metabolism and reproduction: a tale of two enzymes

Journal Article
Michael, A., Thurston, L., & Rae, M. (2003)
Glucocorticoid metabolism and reproduction: a tale of two enzymes. Reproduction, 126, 425-441. https://doi.org/10.1530/rep.0.1260425
Within potential target cells, the actions of physiological glucocorticoids (cortisol and corticosterone) are modulated by isoforms of the enzyme 11 beta-hydroxysteroid dehydr...

Environmental influences on the fetus and neonate—timing, mechanisms of action and effects on subsequent adult function

Journal Article
Rhind, S., Rae, M., & Brooks, A. (2003)
Environmental influences on the fetus and neonate—timing, mechanisms of action and effects on subsequent adult function. Domestic Animal Endocrinology, 25(1), 3-11. https://doi.org/10.1016/S0739-7240%2803%2900041-9
Environmental influences on fetal and neonatal development can affect neural, reproductive, immune and cardiovascular function in adult humans and animals. The effects can be ...

Undernutrition of ewe lambs in utero and in early post-natal life does not affect hypothalamic–pituitary function in adulthood

Journal Article
Borwick, S., Rae, M., Brooks, J., McNeilly, A., Racey, P., & Rhind, S. (2003)
Undernutrition of ewe lambs in utero and in early post-natal life does not affect hypothalamic–pituitary function in adulthood. Animal Reproduction Science, 77(1-2), 61-70. https://doi.org/10.1016/S0378-4320%2802%2900261-0
The effect of undernutrition in utero, during late gestation (from day 100), and early neonatal life on hypothalamic–pituitary function was investigated in female lambs born t...

Previous Post Grad projects

Non-Napier PhD or MSc by Research supervisions

  • Reproductive and metabolic programming by exogenous steroids
  • Optimisation and validation of an in vitro bioassay as a tool for measuring Luteinising Hormone in several species of mammals