Nick Wheelhouse
Nick Wheelhouse

Dr Nick Wheelhouse BSc (Hons) PhD

Associate Professor

Biography

Associate Professor in microbiology and Deputy lead of the Centre for Biomedicine and Global Health within the School of Applied Sciences at Edinburgh Napier University.

I started my academic career as a Postdoctoral Research Fellow in the Department of Pathology at Edinburgh University where I worked in the areas of liver cancer and transplantation failure. It was here that I developed a keen interest in understanding the underlying causes of disease pathogenesis. I then moved to the Moredun Research Institute where I worked first as a Postdoctoral scientist and then as as Senior Postdoctoral Scientist focusing my research into the effects and impacts of bacterial infections which cause reproductive complications in both humans and livestock.

I co-lead of the Global research alliance Animal Health and Greenhouse Gas Intensity Network and I am a Trustee of the British Society for Animal Science. I hold memberships of Edinburgh Infectious Diseases, the hub for infectious disease research in Edinburgh, the Society for Reproduction and Fertility, Microbiology Society, British Society of Animal Science and I am a Fellow of the Higher Education Academy.

I have a breadth of research interests however the main areas of my research are the diagnosis, immunopathogenesis and epidemiology of reproductive infections particularly zoonoses that can be spread from animals to humans. I am particularly interested in understanding the impact of these infections on human health and quantifying their effects on livestock farming.

My work involves collaboration with multiple partner organisations in the UK and overseas, including NHS Lothian, the Institute of Biodiversity Animal Health and Comparative Medicine at the University of Glasgow in the UK where I am an Affiliated Researcher and the Royal (Dick) School of Veterinary Studies at the University of Edinburgh, where I am an honorary Fellow. Internationally I have collaborations with Kwame Nkrumah University of Science and Technology in Ghana, The University of Nairobi, and International Livestock Research Institute in Kenya.

Themes

Esteem

Advisory panels and expert committees or witness

  • Committee member Food Standards Agency Joint Expert Group on Animal Feed and Feed Additives - AFFAJEG
  • Food Standards Agency Advisory Committee on Animal Feedingstuffs - ACAF
  • Network Lead- Animal Health & Greenhouse Gas Emissions Intensity Network
  • Royal Society of Biology Animal Science Group
  • Council member- Society for Reproduction and Fertility
  • International External advisor for the Instituto Nacional de Tecnologia Agropecuaria (INTA) in Argentina (2015-)
  • Expert of Science and Technology Evaluation- National Center of Science and Technology Evaluation, Kazakhstan

 

Conference Organising Activity

  • Judging panel SRF Posters and 'Postdoctoral presentation' session Fertility 2022
  • Conference Presentation- Joint meeting of ESCCAR/ESCR 2022
  • Conference Presentation: Fertility 2022
  • Conference Presentation: Fertility 2021, Online
  • Judging panel 'Postgraduate presentation' Fertility 2021
  • Royal Society Westminster Pairing
  • Session Chair (Fertility 2020)
  • Judging panel 'Postgraduate presentation' and 'Postdoctoral presentation' sessions Fertility 2020
  • Judging panel 'Best Poster' and 'ECR presentation' Fertility 2019, Birmingham
  • Workshop organiser: KNUST, Kumasi, Ghana
  • Conference Presentation: Fertility 2018, Liverpool
  • Conference Presentation: European Society for Coxiellosis, Chlamydioses, Anaplasmoses and Rickettsioses, Marseille,
  • Conference presentation: European Society for Chlamydia Research, Cambridge
  • Conference Presentation: SRF annual meeting, Cambridge
  • Conference Presentation: Edinburgh Infectious Diseases Symposium, 2015
  • Conference Presentation: European Meeting for Animal Chlamydioses, Paris
  • Conference Presentation: European Meeting for Animal Chlamydioses, Jena
  • Conference Presentation: European Society for Chlamydia Research, Amsterdam
  • Conference Presentation: FEMAC meeting, Murcia, 2009
  • Conference Presentation: European Society for Chlamydia Research, Aarhus, Denmark
  • Conference Presentation: COST855 meeting Pulawy, Poland
  • Conference Presentation: British Society for Immunology, Glasgow
  • Conference Presentation: COST855 meeting, Edinburgh
  • Conference Presentation: British Society of Animal Science, Scarborough
  • Conference Presentation: British Society for Nutrition, Glasgow

 

Editorial Activity

  • Associate Editor Veterinary Sciences
  • Reproduction & Fertility- Associate Editor
  • Frontiers in Veterinary Science- Associate Editor
  • Editorial Board Member 'Frontiers in Microbiology'
  • Associate Editor 'Heliyon' Elsevier

 

External Examining/Validations

  • The Royal Veterinary College- External Examiner

 

Grant Funding Panel Member

  • SRF- Grant awarding committee

 

Grant Reviewer

  • The University of Veterinary Medicine Vienna 'Top Vet Science' call
  • Assessor Innovate UK
  • Research Foundation- Flanders (FWO) Grant Reviewer
  • BBSRC Grant Reviewer
  • The German Israeli Foundation for Scientific Research and Development
  • National Science Foundation (US)
  • MRC Grant Reviewer

 

Invited Speaker

  • Invited Seminar Speaker- Mazingira Centre, ILRI, Nairobi
  • Plenary Speaker 'Vision 2022', Cote d'Ivoire
  • Animal Health Network update: GRA LRG meeting 2022
  • Invited Speaker: SRF Early Career Research Workshop, Edinburgh
  • Acceptability of Extragenital Chlamydia testing in young women- NHS Research Scotland Annual Conference
  • Invited Speaker: Kumasi Centre for Collaborative Research, Kumasi, Ghana
  • Invited Speaker: Kwame Nkrumah University of Science and Technology, Kumasi, Ghaa
  • 'Q-fever' Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow
  • Invited talk: School of Life Sciences, Edinburgh Napier University
  • FACCE JPI MACSUR LiveM meeting Potsdam, June 2016 'Animal Health and Greenhouse Gas Emissions Network: Achievements and Future'
  • Global Research Alliance on climate change meeting Reading, June 2015. ‘Investigations into novel pathogens associated with bovine reproductive failure’.
  • Sheep Veterinary Society meeting, Jersey 2010 ‘Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion’

 

Media Activity

  • The Impact of infectious disease on livestock health-Blog
  • Online Policy Brief- Improving animal health: a key to sustainable livestock production and better human health
  • https://whylivestockmatter.org/articles/improving-animal-health-key-sustainable-livestock-production-and-better-human-health
  • Q-fever podcast- Veterinary times
  • The Crofter Issue 88 Aug 2010 ‘Controlling chlamydial abortion in sheep’
  • The Sheep Farmer July/Aug 2010 ‘Chlamydial abortion’
  • The Sheep Farmer March/ April 2012 ‘Controlling chlamydial abortion’
  • ‘Chlamydial infection of sheep an infectious cause of prenatal lamb death’ http://www.knowledgescotland.org/briefings.php?id=209

 

Membership of Professional Body

  • Fellow of the Higher Education Academy

 

Public Engagement Activity

  • Royal Highland Show 2011
  • NSA National Event 2010
  • NSA Scotsheep 2011
  • Royal Highland Show 2010
  • Moredun Animal Health Roadshow (Peebles) 2011
  • Royal Highland Show 2013
  • National Sheep Association (NSA) Scotsheep 2010

 

Public/Community Engagement

  • Livestock Health Workshop- Nandi County Kenya

 

Research Degree External Examining

  • External PhD examination University of Southampton 'Studies on the plasmid-based genetic tools for C. muridarum: progress towards a replicating vector for transposon mutagenesis'
  • University College Dublin PhD examiner 'Bovine sperm sexing impacts sperm morphokinetics, gameto-maternal interaction and subsequent early embryonic development'

 

Reviewing

  • Proceedings of the Royal Society B
  • Journal of Zoo and Wildlife Medicine
  • Epidemiology and infection
  • Frontiers in Microbiology
  • Veterinary Pathology
  • Transboundary and Emerging Diseases
  • BMC Veterinary Research
  • Veterinary Immunology & Immunopathology
  • PeerJ
  • Microbes & infection
  • Veterinary Microbiology
  • Veterinary Journal
  • Chemistry & Biology
  • Veterinary Record
  • Pathogens & disease
  • Emerging Infectious Diseases

 

Visiting Positions

  • Honorary Fellow Royal (Dick) School of Veterinary Studies
  • International Livestock Research Institute (Nairobi)
  • Glasgow University IBACHM- Affiliate Researcher
  • Guest Lecturer- University of Liverpool Veterinary School

 

Date


80 results

Risk factors associated with Lawsonia intracellularis in English pig farms

Journal Article
Bae, J. K., Wieland, B., Sait, M., Longbottom, D., Smith, D. G. E., Alarcon, P. & Wheelhouse, N. (2013)
Risk factors associated with Lawsonia intracellularis in English pig farms. Veterinary Journal. 197(3), 707-11. doi:10.1016/j.tvjl.2013.03.020. ISSN 1090-0233
Porcine proliferative enteropathy (PPE) caused by the bacterium Lawsonia intracellularis causes considerable economic loss to the pig industry. The objective of this study was...

Genome Sequence of Lawsonia intracellularis Strain N343, Isolated from a Sow with Hemorrhagic Proliferative Enteropathy

Journal Article
Sait, M., Aitchison, K., Wheelhouse, N., Wilson, K., Alex Lainson, F., Longbottom, D., & Smith, D. G. E. (2013)
Genome Sequence of Lawsonia intracellularis Strain N343, Isolated from a Sow with Hemorrhagic Proliferative Enteropathy. Genome Announcements, 1(1), https://doi.org/10.1128/genomeA.00027-13
Lawsonia intracellularis is the etiological agent of proliferative enteropathy (PE), causing mild or acute hemorrhagic diarrhea in infected animals. Here we report the genome ...

Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep

Journal Article
Longbottom, D., Livingstone, M., Maley, S., van der Zon, A., Rocchi, M., Wilson, K., …Buxton, D. (2013)
Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep. PLOS ONE, 8(2), https://doi.org/10.1371/journal.pone.0057950
BACKGROUND: Latency is a key feature of the animal pathogen Chlamydia abortus, where infection remains inapparent in the non-pregnant animal and only becomes evident during a ...

Chlamydia in cases of cattle pneumonia in Scotland

Journal Article
Wheelhouse, N., Longbottom, D., & Willoughby, K. (2013)
Chlamydia in cases of cattle pneumonia in Scotland. Veterinary Record, 172(4), 110. https://doi.org/10.1136/vr.f469

Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle

Journal Article
Wheelhouse, N. M., Sait, M., Aitchison, K., Livingstone, M., Wright, F., McLean, K., …Longbottom, D. (2012)
Processing of Chlamydia abortus polymorphic membrane protein 18D during the chlamydial developmental cycle. PLOS ONE, 7, https://doi.org/10.1371/journal.pone.0049190
BACKGROUND: Chlamydia possess a unique family of autotransporter proteins known as the Polymorphic membrane proteins (Pmps). While the total number of pmp genes varies between...

Evaluation of the impact and control of enzootic abortion of ewes

Journal Article
Longbottom, D., Entrican, G., Wheelhouse, N., Brough, H., & Milne, C. (2013)
Evaluation of the impact and control of enzootic abortion of ewes. Veterinary Journal, 195(2), 257-259. https://doi.org/10.1016/j.tvjl.2012.06.018
Despite the availability of effective management and treatment strategies, Chlamydia abortus remains the single most frequently diagnosed cause of infectious ovine abortion (e...

Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle

Journal Article
Longbottom, D., Wheelhouse, N., Sait, M., Wilson, K., Aitchison, K., McLean, K., & Smith, D. G. E. (2012)
Expression patterns of five polymorphic membrane proteins during the Chlamydia abortus developmental cycle. Veterinary Microbiology, 160(3-4), 525-529. https://doi.org/10.1016/j.vetmic.2012.06.017
It has been suggested that polymorphic membrane proteins (Pmps) belonging to the Type V autotransporter protein family play an important role in the pathogenesis of Chlamydia ...

Involvement of Parachlamydia in bovine abortions in Scotland

Journal Article
Howie, F., Gidlow, J., Greub, G., Wheelhouse, N., Dagleish, M., & Longbottom, D. (2012)
Involvement of Parachlamydia in bovine abortions in Scotland. Veterinary Journal, 193(2), 586-588. https://doi.org/10.1016/j.tvjl.2012.01.008
Bovine abortion represents a major animal welfare issue and a cause of substantial economic loss yet the rate of successful diagnosis remains low. Chlamydia-related organisms ...

New challenges for vaccination to prevent chlamydial abortion in sheep

Journal Article
Entrican, G., Wheelhouse, N., Wattegedera, S. R., & Longbottom, D. (2012)
New challenges for vaccination to prevent chlamydial abortion in sheep. Comparative Immunology, Microbiology and Infectious Diseases, 35(3), 271-276. https://doi.org/10.1016/j.cimid.2011.12.001
Ovine enzootic abortion (OEA) is caused by the obligate intracellular Gram-negative bacterium Chlamydia abortus. OEA remains a common cause of infectious abortion in many shee...

Endemic and emerging chlamydial infections of animals and their zoonotic implications

Journal Article
Wheelhouse, N., & Longbottom, D. (2011)
Endemic and emerging chlamydial infections of animals and their zoonotic implications. Transboundary and Emerging Diseases, 59(4), 283-291. https://doi.org/10.1111/j.1865-1682.2011.01274.x
The Chlamydiae are a diverse group of obligate intracellular Gram-negative bacteria that are known to infect a wide variety of host species and are responsible for a wide rang...

Pre-Napier Funded Projects

  • BBSRC/ Zoetis IPA Chlamydia-like organisms as a novel cause of bovine reproductive failure (£1.2 M)
  • Chief Scientist Office: Mitochondrial DNA deletions in Barrett's oesophagus (£25k)
  • Melville Trust: Mitochondrial DNA mutations as a sentinel marker of hepatocarcinogenesis (£50k)

Current Post Grad projects

Previous Post Grad projects