Nick Wheelhouse
Nick Wheelhouse

Dr Nick Wheelhouse BSc (Hons) PhD

Associate Professor

Biography

Associate Professor in microbiology and Deputy lead of the Centre for Biomedicine and Global Health within the School of Applied Sciences at Edinburgh Napier University.

I started my academic career as a Postdoctoral Research Fellow in the Department of Pathology at Edinburgh University where I worked in the areas of liver cancer and transplantation failure. It was here that I developed a keen interest in understanding the underlying causes of disease pathogenesis. I then moved to the Moredun Research Institute where I worked first as a Postdoctoral scientist and then as as Senior Postdoctoral Scientist focusing my research into the effects and impacts of bacterial infections which cause reproductive complications in both humans and livestock.

I co-lead of the Global research alliance Animal Health and Greenhouse Gas Intensity Network and I am a Trustee of the British Society for Animal Science. I hold memberships of Edinburgh Infectious Diseases, the hub for infectious disease research in Edinburgh, the Society for Reproduction and Fertility, Microbiology Society, British Society of Animal Science and I am a Fellow of the Higher Education Academy.

I have a breadth of research interests however the main areas of my research are the diagnosis, immunopathogenesis and epidemiology of reproductive infections particularly zoonoses that can be spread from animals to humans. I am particularly interested in understanding the impact of these infections on human health and quantifying their effects on livestock farming.

My work involves collaboration with multiple partner organisations in the UK and overseas, including NHS Lothian, the Institute of Biodiversity Animal Health and Comparative Medicine at the University of Glasgow in the UK where I am an Affiliated Researcher and the Royal (Dick) School of Veterinary Studies at the University of Edinburgh, where I am an honorary Fellow. Internationally I have collaborations with Kwame Nkrumah University of Science and Technology in Ghana, The University of Nairobi, and International Livestock Research Institute in Kenya.

Themes

Esteem

Advisory panels and expert committees or witness

  • Committee member Food Standards Agency Joint Expert Group on Animal Feed and Feed Additives - AFFAJEG
  • Food Standards Agency Advisory Committee on Animal Feedingstuffs - ACAF
  • Network Lead- Animal Health & Greenhouse Gas Emissions Intensity Network
  • Council member- Society for Reproduction and Fertility
  • Royal Society of Biology Animal Science Group
  • International External advisor for the Instituto Nacional de Tecnologia Agropecuaria (INTA) in Argentina (2015-)
  • Expert of Science and Technology Evaluation- National Center of Science and Technology Evaluation, Kazakhstan

 

Conference Organising Activity

  • Judging panel SRF Posters and 'Postdoctoral presentation' session Fertility 2022
  • Conference Presentation- Joint meeting of ESCCAR/ESCR 2022
  • Conference Presentation: Fertility 2022
  • Royal Society Westminster Pairing
  • Judging panel 'Postgraduate presentation' Fertility 2021
  • Conference Presentation: Fertility 2021, Online
  • Judging panel 'Postgraduate presentation' and 'Postdoctoral presentation' sessions Fertility 2020
  • Session Chair (Fertility 2020)
  • Workshop organiser: KNUST, Kumasi, Ghana
  • Judging panel 'Best Poster' and 'ECR presentation' Fertility 2019, Birmingham
  • Conference Presentation: Fertility 2018, Liverpool
  • Conference Presentation: European Society for Coxiellosis, Chlamydioses, Anaplasmoses and Rickettsioses, Marseille,
  • Conference presentation: European Society for Chlamydia Research, Cambridge
  • Conference Presentation: European Meeting for Animal Chlamydioses, Paris
  • Conference Presentation: SRF annual meeting, Cambridge
  • Conference Presentation: Edinburgh Infectious Diseases Symposium, 2015
  • Conference Presentation: European Meeting for Animal Chlamydioses, Jena
  • Conference Presentation: European Society for Chlamydia Research, Amsterdam
  • Conference Presentation: FEMAC meeting, Murcia, 2009
  • Conference Presentation: European Society for Chlamydia Research, Aarhus, Denmark
  • Conference Presentation: COST855 meeting Pulawy, Poland
  • Conference Presentation: British Society for Immunology, Glasgow
  • Conference Presentation: COST855 meeting, Edinburgh
  • Conference Presentation: British Society for Nutrition, Glasgow
  • Conference Presentation: British Society of Animal Science, Scarborough

 

Editorial Activity

  • Associate Editor Veterinary Sciences
  • Reproduction & Fertility- Associate Editor
  • Frontiers in Veterinary Science- Associate Editor
  • Editorial Board Member 'Frontiers in Microbiology'
  • Associate Editor 'Heliyon' Elsevier

 

External Examining/Validations

  • The Royal Veterinary College- External Examiner

 

Grant Funding Panel Member

  • SRF- Grant awarding committee

 

Grant Reviewer

  • Assessor Innovate UK
  • The University of Veterinary Medicine Vienna 'Top Vet Science' call
  • Research Foundation- Flanders (FWO) Grant Reviewer
  • BBSRC Grant Reviewer
  • The German Israeli Foundation for Scientific Research and Development
  • National Science Foundation (US)
  • MRC Grant Reviewer

 

Invited Speaker

  • Invited Seminar Speaker- Mazingira Centre, ILRI, Nairobi
  • Plenary Speaker 'Vision 2022', Cote d'Ivoire
  • Animal Health Network update: GRA LRG meeting 2022
  • Invited Speaker: SRF Early Career Research Workshop, Edinburgh
  • Acceptability of Extragenital Chlamydia testing in young women- NHS Research Scotland Annual Conference
  • Invited Speaker: Kumasi Centre for Collaborative Research, Kumasi, Ghana
  • Invited Speaker: Kwame Nkrumah University of Science and Technology, Kumasi, Ghaa
  • 'Q-fever' Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow
  • Invited talk: School of Life Sciences, Edinburgh Napier University
  • FACCE JPI MACSUR LiveM meeting Potsdam, June 2016 'Animal Health and Greenhouse Gas Emissions Network: Achievements and Future'
  • Sheep Veterinary Society meeting, Jersey 2010 ‘Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion’
  • Global Research Alliance on climate change meeting Reading, June 2015. ‘Investigations into novel pathogens associated with bovine reproductive failure’.

 

Media Activity

  • The Impact of infectious disease on livestock health-Blog
  • https://whylivestockmatter.org/articles/improving-animal-health-key-sustainable-livestock-production-and-better-human-health
  • Online Policy Brief- Improving animal health: a key to sustainable livestock production and better human health
  • Q-fever podcast- Veterinary times
  • The Sheep Farmer July/Aug 2010 ‘Chlamydial abortion’
  • The Sheep Farmer March/ April 2012 ‘Controlling chlamydial abortion’
  • ‘Chlamydial infection of sheep an infectious cause of prenatal lamb death’ http://www.knowledgescotland.org/briefings.php?id=209
  • The Crofter Issue 88 Aug 2010 ‘Controlling chlamydial abortion in sheep’

 

Membership of Professional Body

  • Fellow of the Higher Education Academy

 

Public Engagement Activity

  • NSA National Event 2010
  • National Sheep Association (NSA) Scotsheep 2010
  • Moredun Animal Health Roadshow (Peebles) 2011
  • Royal Highland Show 2011
  • NSA Scotsheep 2011
  • Royal Highland Show 2013
  • Royal Highland Show 2010

 

Public/Community Engagement

  • Livestock Health Workshop- Nandi County Kenya

 

Research Degree External Examining

  • External PhD examination University of Southampton 'Studies on the plasmid-based genetic tools for C. muridarum: progress towards a replicating vector for transposon mutagenesis'
  • University College Dublin PhD examiner 'Bovine sperm sexing impacts sperm morphokinetics, gameto-maternal interaction and subsequent early embryonic development'

 

Reviewing

  • Proceedings of the Royal Society B
  • Epidemiology and infection
  • Journal of Zoo and Wildlife Medicine
  • Frontiers in Microbiology
  • Transboundary and Emerging Diseases
  • Veterinary Pathology
  • Emerging Infectious Diseases
  • PeerJ
  • Veterinary Microbiology
  • Veterinary Journal
  • Veterinary Record
  • BMC Veterinary Research
  • Veterinary Immunology & Immunopathology
  • Pathogens & disease
  • Microbes & infection
  • Chemistry & Biology

 

Visiting Positions

  • International Livestock Research Institute (Nairobi)
  • Honorary Fellow Royal (Dick) School of Veterinary Studies
  • Glasgow University IBACHM- Affiliate Researcher
  • Guest Lecturer- University of Liverpool Veterinary School

 

Date


80 results

Identification, sequencing and molecular analysis of Chp4, a novel chlamydiaphage of Chlamydophila abortus belonging to the family Microviridae

Journal Article
Sait, M., Livingstone, M., Graham, R., Inglis, N. F., Wheelhouse, N., & Longbottom, D. (2011)
Identification, sequencing and molecular analysis of Chp4, a novel chlamydiaphage of Chlamydophila abortus belonging to the family Microviridae. Journal of General Virology, 92(7), 1733-1737. https://doi.org/10.1099/vir.0.031583-0
Members of the family Microviridae have been identified in a number of chlamydial species infecting humans (phage CPAR39 in Chlamydophila pneumoniae), other mammals (phiCPG1 i...

Genome sequence of the Chlamydophila abortus variant strain LLG

Journal Article
Sait, M., Clark, E. M., Wheelhouse, N., Livingstone, M., Spalding, L., Siarkou, V. I., …Longbottom, D. (2011)
Genome sequence of the Chlamydophila abortus variant strain LLG. Journal of Bacteriology, 193(16), 4276-4277. https://doi.org/10.1128/JB.05290-11
Chlamydophila abortus is a common cause of ruminant abortion. Here we report the genome sequence of strain LLG, which differs genotypically and phenotypically from the wild-ty...

Proteolysis-inducing factor core peptide mediates dermcidin-induced proliferation of hepatic cells through multiple signalling networks

Journal Article
Lowrie, A. G., Dickinson, P., Wheelhouse, N., Stewart, G. D., Ross, A. J., Forster, T., & Ross, J. A. (2011)
Proteolysis-inducing factor core peptide mediates dermcidin-induced proliferation of hepatic cells through multiple signalling networks. International Journal of Oncology, 39(3), 709-18. https://doi.org/10.3892/ijo.2011.1064
Dermcidin is a candidate oncogene capable of increasing the number of cultured neuronal, breast cancer and prostate cancer cells and improving the survival of hepatic c...

Molecular detection of Chlamydia-like organisms in cattle drinking water

Journal Article
Wheelhouse, N., Saita, M., Gidlow, J., Deuchande, R., Borel, N., Baily, J., …Longbottom, D. (2011)
Molecular detection of Chlamydia-like organisms in cattle drinking water. Veterinary Microbiology, 152(1-2), 196-199. https://doi.org/10.1016/j.vetmic.2011.03.040
A substantial proportion of the causes of infectious bovine abortion remain largely undiagnosed, potentially due to the presence of previously unrecognised infectious agents. ...

Genetic variability of Chlamydophila abortus strains assessed by PCR-RFLP analysis of polymorphic membrane protein-encoding genes

Journal Article
Saita, M., Clarka, E. M., Wheelhouse, N., Spalding, L., Livingstone, M., Sachse, K., …Longbottom, D. (2011)
Genetic variability of Chlamydophila abortus strains assessed by PCR-RFLP analysis of polymorphic membrane protein-encoding genes. Veterinary Microbiology, 151(3-4), 284-290. https://doi.org/10.1016/j.vetmic.2011.03.005
This study used PCR-RFLP to investigate the genetic variability of pmp-encoding genes from fifty-two Chlamydophila abortus (C. abortus) strains originating from abortion cases...

Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFkappaB activation resulting in a microenvironment predisposed to ectopic pregnancy

Journal Article
Shaw, J. L. V., Wills, G. S., Lee, K., Horner, P. J., McClure, M. O., Abrahams, V. M., …Horne, A. W. (2011)
Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFkappaB activation resulting in a microenvironment predisposed to ectopic pregnancy. American Journal of Pathology, 178(1), 253-60. https://doi.org/10.1016/j.ajpath.2010.11.019
Chlamydia trachomatis and smoking are major risk factors for tubal ectopic pregnancy (EP), but the underlying mechanisms of these associations are not completely understood. F...

Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression

Journal Article
Fitch, P., Wheelhouse, N., Bowles, P., Paterson, M., Longbottom, D., Entrican, G., & Howie, S. (2010)
Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression. Clinical and Experimental Immunology, 162(2), 372-378. https://doi.org/10.1111/j.1365-2249.2010.04231.x
Infection with Chlamydia pneumoniae (Cp) accounts for around 10% of community acquired bacterial pneumonia and has been associated with other chronic inflammatory conditions. ...

Novel chlamydia-like organisms as cause of bovine abortions, UK

Journal Article
Wheelhouse, N., Katzer, F., Wright, F., & Longbottom, D. (2010)
Novel chlamydia-like organisms as cause of bovine abortions, UK. Emerging Infectious Diseases, 16(8), 1323-1324. https://doi.org/10.3201/eid1608.091878

Immunological paradigms and the pathogenesis of ovine chlamydial abortion

Journal Article
Entrican, G., Wattegedera, S., Wheelhouse, N., Allan, A., & Rocchi, M. (2010)
Immunological paradigms and the pathogenesis of ovine chlamydial abortion. American Journal of Reproductive Immunology, 64(4), 287-294. https://doi.org/10.1111/j.1600-0897.2010.00907.x
Successful mammalian pregnancy involves complex immunological interactions between the mother and foetus that are not yet fully understood. A number of immunological paradigms...

Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube

Journal Article
Duncan, W. C., McDonald, S. E., Dickinson, R. E., Shaw, J. L. V., Lourenco, P. C., Wheelhouse, N., …Horne, A. W. (2010)
Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube. Molecular Human Reproduction, 16, 950-959. https://doi.org/10.1093/molehr/gaq055
We investigated whether the repulsive SLIT/ROBO pathway is expressed in the endometrium and is negatively regulated during implantation. We also examined whether deficient exp...

Pre-Napier Funded Projects

  • BBSRC/ Zoetis IPA Chlamydia-like organisms as a novel cause of bovine reproductive failure (£1.2 M)
  • Chief Scientist Office: Mitochondrial DNA deletions in Barrett's oesophagus (£25k)
  • Melville Trust: Mitochondrial DNA mutations as a sentinel marker of hepatocarcinogenesis (£50k)

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