Nanoparticles and Neutrophil Activation
Presentation / Conference
Dickson, C., Prach, M., Fraser, J., Ingram, L., Barlow, P., Hutchison, G., …Malone, E. (2012, February)
Nanoparticles and Neutrophil Activation. Presented at NanoImpactNet-QNANO conference - European Network on the Health and Environmental Impact of Nanomaterials, Dublin, Ireland
Neutrophils, the rapid responders of the innate immune system, are central to the initial immune responses of a host to foreign particles. Circulating in the blood, they are t...
The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line
Journal Article
Clift, M. J., Rothen-Rutishauser, B., Brown, D. M., Duffin, R., Donaldson, K., Proudfoot, L., Guy, K., & Stone, V. (2008)
The impact of different nanoparticle surface chemistry and size on uptake and toxicity in a murine macrophage cell line. Toxicology and Applied Pharmacology, 232(3), 418-427. https://doi.org/10.1016/j.taap.2008.06.009
This study investigated the uptake, kinetics and cellular distribution of different surface coated quantum dots (QDs) before relating this to their toxicity. J774.A1 cells wer...
Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation
Journal Article
Zhao, M., Brown, D. M., MacCallum, J., & Proudfoot, L. (2008)
Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation. Parasite Immunology, 31(1), 50-56. https://doi.org/10.1111/j.1365-3024.2008.01073.x
The anti-inflammatory properties of parasitic helminths have been largely linked to their excretory-secretory (ES) products. Some studies have noted a lack of TNF-alpha produc...
Accute toxicity of linear alkylbenzene to Caenorhabditis elegans Maupas, 1900 in soil.
Journal Article
Johnson, S. J., Castan, M., Proudfoot, L., Barry, D. A. & Christofi, N. (2007)
Accute toxicity of linear alkylbenzene to Caenorhabditis elegans Maupas, 1900 in soil. Bulletin of Environmental Contamination and Toxicology. 79, 41-44. doi:10.1007/s00128-007-9195-6. ISSN 0007-4861
Linear alkybenzene (LAB) is a light non-aqueous phase liquid (LNAPL) whose primary use is as a precursor in the manufacture of linear alkylbenzene sulphonate (LAS) detergents....
Parasitic helminths tip the balance: potential anti-inflammatory therapies
Journal Article
Proudfoot, L. (2004)
Parasitic helminths tip the balance: potential anti-inflammatory therapies. Immunology, 113(4), 438-440. https://doi.org/10.1111/j.1365-2567.2004.01996.x
Parasitic helminths are worms that are classified within the phyla Nematoda (roundworms) and Platyhelminthes (flatworms) (see Table 1). Some nematode species, Filariae being a...
Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis
Journal Article
Keir, P. A., Brown, D. M., Clouter-Baker, A., Harcus, Y. M., & Proudfoot, L. (2004)
Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis. Parasite Immunology, 26(3), 137-139. https://doi.org/10.1111/j.0141-9838.2004.00692.x
It has been reported that excretory–secretory (ES) material from the parasitic nematode Nippostrongylus brasiliensis has potential modulatory effects on the host's immune syst...
Expression of C-Reactive Protein in Human Lung Epithelial Cells and Upregulation by Cytokines and Carbon Particles
Journal Article
Ramage, L., Proudfoot, L., & Guy, K. (2004)
Expression of C-Reactive Protein in Human Lung Epithelial Cells and Upregulation by Cytokines and Carbon Particles. Inhalation Toxicology, 16(9), 607-613. https://doi.org/10.1080/08958370490464599
C-reactive protein (CRP) is the prototypic human acute-phase protein and is found at increased levels in the blood during episodes of inflammation. CRP was generally thought t...
Anti-inflammatory responses and oxidative stress in Nippostrongylus brasiliensis-induced pulmonary inflammation.
Journal Article
McNeil, K. S., Knox, D. P. & Proudfoot, L. (2002)
Anti-inflammatory responses and oxidative stress in Nippostrongylus brasiliensis-induced pulmonary inflammation. Parasite Immunology. 24, 15-22. doi:10.1046/j.0141-9838.2001.00428.x. ISSN 0141-9838
Migration of L3 larvae of Nippostrongylus brasiliensis through the lungs of the rat, during primary infection, was studied at 24 h, 72 h and 8 days. At 24 h p.i., there was ev...
Regulation of macrophage IL-12 synthesis byLeishmania phosphoglycans
Journal Article
Piedrafita, D., Proudfoot, L., Nikolaev, A. V., Xu, D., Sands, W., Feng, G., …Liew, F. Y. (1999)
Regulation of macrophage IL-12 synthesis byLeishmania phosphoglycans. European Journal of Immunology, 29(1), 235-244. https://doi.org/10.1002/%28sici%291521-4141%28199901%2929%3A013.0.co%3B2-s
It is now generally accepted that IFN‐γ, secreted by Th1 cells, is the most potent cytokine leading to macrophage activation and host resistance against infection with the int...
Cytokines and nitric oxide as effector molecules against parasitic infections
Journal Article
Liew, F. Y., Wei, X., & Proudfoot, L. (1997)
Cytokines and nitric oxide as effector molecules against parasitic infections. Philosophical Transactions B: Biological Sciences, 352(1359), 1311-1315. https://doi.org/10.1098/rstb.1997.0115
Nitric oxide (NO) derived from L-arginine by the catalytic action of inducible NO synthase (iNOS) plays an important role in killing parasites. Many cell types express high le...