Research Output

The conserved metalloprotease invadolysin localizes to the surface of lipid droplets

  Invadolysin is a metalloprotease conserved in many different
organisms, previously shown to be essential in Drosophila with
roles in cell division and cell migration. The gene seems to be
ubiquitously expressed and four distinct splice variants have
been identified in human cells but not in most other species
examined. Immunofluorescent detection of human invadolysin
in cultured cells reveals the protein to be associated with the
surface of lipid droplets. By means of subcellular fractionation,
we have independently confirmed the association of invadolysin
with lipid droplets. We thus identify invadolysin as the first
metalloprotease located on these dynamic organelles. In
addition, analysis of larval fat-body morphological appearance
and triglyceride levels in the Drosophila invadolysin mutant
suggests that invadolysin plays a role in lipid storage or

  • Type:


  • Date:

    25 August 2009

  • Publication Status:


  • Publisher

    The Company of Biologists

  • DOI:


  • ISSN:


  • Library of Congress:

    QP Physiology

  • Dewey Decimal Classification:

    571 Physiology & related subjects


Cobbe, N., Marshall, K. M., Rao, S. G., Chang, C., Di Cara, F., Duca, E., …Heck, M. M. S. (2009). The conserved metalloprotease invadolysin localizes to the surface of lipid droplets. Journal of Cell Science. 122(18), 3414-3423. doi:10.1242/jcs.044610. ISSN 0021-9533



Invadolysin, Lipid droplets, Metalloprotease, Phylogeny

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