Sharron Vass
Sharron Vass

Dr Sharron Vass BSc. Hons., PhD, SFHEA

Lecturer

Biography

Dr Sharron Vass BSc (Hons) PhD SFHEA , Programme Leader MSc Biomedical Sciences, School of Applied Sciences, Edinburgh Napier University, Scotland, UK.

Research Interests
My PhD studies were completed at the Institute of Cell and Molecular Biology, University of Edinburgh (2005). My research involved investigating the stability of the cohesion complex, the molecular ‘glue’ that holds chromosomes together during the cell cycle. This work contributed to a rapidly expanding field and has been cited more than 200 times.

My post-doctoral research was undertaken at the Queen’s Medical Research Institute, University of Edinburgh, where I was investigating the role of metalloproteinase enzymes in cell migration processes. I developed novel microscopy techniques for visualising the formation of developing blood vessels in live zebrafish embryos and was invited to teach a 5-day course on these techniques at the Karolinska Institute, Stockholm.

In 2014, I was appointed as a lecturer in Biomedical Sciences at Edinburgh Napier University and established my own research interests initially focusing on the molecular pathways regulating cell migration in highly migratory melanoma cells. In collaboration with Dr Usama Ammar, a synthetic chemist, this work has been extended to investigate novel small molecule inhibitors in drug resistant melanoma. More recently, I have been instrumental in developing new application methodologies to investigate the toxicity of vaping fluids on human lung epithelial cells. The toxicology of vaping fluids is of primary public health concern, particularly as these products are targeted at young adolescents.

Academic Leadership
I attained Fellowship of the Higher Education Academy in 2015, and Senior Fellowship in 2022. Widening participation and skills-development within the HE landscapes has been of my key areas of expertise, and I have led several projects to enhance student experience and improve graduate outcomes. I have been invited to present these findings at the UK Advising & Tutoring and Enhancement Themes conferences (2022).

In 2018 I was appointed Programme Leader for the MSc Biomedical Sciences in Hong Kong, which is offered in conjunction with our partner organisation HKU SPACE. This MSc programme is recognised by the Hong Kong Hospital Authority and is the leading international provider of MSc Biomedical Sciences provision in Hong Kong. I have extensive trans-national educational experience including external examining, validation panel membership, and delivered teaching and assessment materials in Sri Lanka, Singapore and Hong Kong
Skills- development and graduate employability is at the heart of what ENU does best, and I work closely with employers to ensure that future recruitment and skills needs are met through curriculum development and CPD provision.

Public engagement promoting science and STEM careers is something I am very passionate about, and I’ve been an invited speaker at a number of PE events including An Afternoon of Science, Soap Box Science (where I stood on a soap box in central Edinburgh and talked about placentas), and Monster Confidence – a event aimed to encourage young women into STEM careers.

Themes

Research Areas

Esteem

Conference Organising Activity

  • Enhancement Themes, Shared Practice
  • Beatson International Cancer Conference, Glasgow

 

External Examining/Validations

  • Validation panel member Hong Kong University SPACE
  • External Examiner Hong Kong University SPACE
  • External Examiner Bournemouth University

 

Fellowships and Awards

  • Senior Fellow of Higher Education Academy
  • Fellow of the Higher Education Academy

 

Invited Speaker

  • Research Talk CBGH CAIR Joint Networking Event
  • An Afternoon of Science, Public Engagement Event, Edinburgh Napier University
  • UK Advising & Tutoring Annual Conference
  • Widening Participation in HE
  • University of Edinburgh - Medical School Careers Day
  • Monster Confidence - STEM Promotion, Heriot Watt Uinversity, Edinburgh
  • Soapbox Science - Public Engagement Event, The Mound, Edinburgh
  • Linking Cell Migration and Angiogenesis in Zebrafish, University of Sheffield
  • Taking the Sticky out of Cohesion, University of Dundee
  • Linking Cell Migration and Angiogenesis in Zebrafish, University of Glasgow
  • Winner - 3 Minute Thesis (2016), School of Applied Sciences, Edinburgh Napier University
  • Imaging Vascular Development and Cell Migration in Zebrafish, Karolinska Institute, Sweden
  • From Flies to Fish (via humans), Centre for Cardiovascular Research, University of Edinburgh

 

Membership of Professional Body

  • Member of British Society for Cell Biology

 

Date


16 results

Margarete Heck (1959–2023): Cell biologist, geneticist, and incandescent social spark

Journal Article
Cobbe, N., Di Cara, F., Spradling, A. C., & Vass, S. (2024)
Margarete Heck (1959–2023): Cell biologist, geneticist, and incandescent social spark. Journal of Cell Biology, 223(1), Article e202311145. https://doi.org/10.1083/jcb.202311145

A role for the metalloprotease invadolysin in insulin signaling and adipogenesis

Journal Article
Chang, C., Abhinav, K., Di Cara, F., Panagakou, I., Vass, S., & Heck, M. M. (2017)
A role for the metalloprotease invadolysin in insulin signaling and adipogenesis. Biological Chemistry, 398(3), 373-393. https://doi.org/10.1515/hsz-2016-0226
Invadolysin is a novel metalloprotease conserved amongst metazoans that is essential for life in Drosophila. We previously showed that invadolysin was essential for the cell c...

Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart

Journal Article
Wilson, K. S., Baily, J., Tucker, C. S., Matrone, G., Vass, S., Moran, C., …Denvir, M. A. (2015)
Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart. Molecular and Cellular Endocrinology, 414, 120-131. https://doi.org/10.1016/j.mce.2015.07.025
Background Transient early-life perturbations in glucocorticoids (GC) are linked with cardiovascular disease risk in later life. Here the impact of early life manipulations o...

Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart

Journal Article
Wilson, K., Baily, J., Tucker, C., Vass, S., Moran, C., Chapman, K., …Denvir, M. (2015)
Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart. Heart, 101(Suppl 4), A107.3-A108. https://doi.org/10.1136/heartjnl-2015-308066.193
Introduction Foetal over-exposure to glucocorticoids (GC) has been associated with cardiovascular disorder in later life however the impact of transient early life alterations...

Invadolysin acts genetically via the SAGA complex to modulate chromosome structure

Journal Article
Janiszewski, M. M., Heck, M. M., Rao, S. G., Janiszewski, M. M., Duca, E., Nelson, B., …Heck, M. M. S. (2015)
Invadolysin acts genetically via the SAGA complex to modulate chromosome structure. Nucleic Acids Research, 43(7), 3546-3562. https://doi.org/10.1093/nar/gkv211
Identification of components essential to chromosome structure and behaviour remains a vibrant area of study. We have previously shown that invadolysin is essential in Drosoph...

Heart on a Plate: Histological and Functional Assessment of Isolated Adult Zebrafish Hearts Maintained in Culture

Journal Article
Pieperhoff, S., Wilson, K. S., Baily, J., de Mora, K., Maqsood, S., Vass, S., …Denvir, M. A. (2014)
Heart on a Plate: Histological and Functional Assessment of Isolated Adult Zebrafish Hearts Maintained in Culture. PLOS ONE, 9(5), https://doi.org/10.1371/journal.pone.0096771
The zebrafish is increasingly used for cardiovascular genetic and functional studies. We present a novel protocol to maintain and monitor whole isolated beating adult zebrafis...

Perturbation of invadolysin disrupts cell migration in zebrafish (Danio rerio)

Journal Article
Vass, S., & Heck, M. M. S. (2013)
Perturbation of invadolysin disrupts cell migration in zebrafish (Danio rerio). Experimental Cell Research, 319(8), 1198-1212. https://doi.org/10.1016/j.yexcr.2013.02.005
Invadolysin is an essential, conserved metalloprotease which links cell division with cell migration and is intriguingly associated with lipid droplets. In this work we examin...

Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling

Journal Article
Bolukbasi, E., Vass, S., Cobbe, N., Nelson, B., Simossis, V., Dunbar, D. R., & Heck, M. M. S. (2012)
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. Open Biology, 2(1), 110031-110031. https://doi.org/10.1098/rsob.110031
Multi-cellular organisms need to successfully link cell growth and metabolism to environmental cues during development. Insulin receptor–target of rapamycin (InR–TOR) signalli...

The conserved metalloprotease invadolysin localizes to the surface of lipid droplets

Journal Article
Cobbe, N., Marshall, K. M., Rao, S. G., Chang, C., Di Cara, F., Duca, E., …Heck, M. M. (2009)
The conserved metalloprotease invadolysin localizes to the surface of lipid droplets. Journal of Cell Science, 122(18), 3414-3423. https://doi.org/10.1242/jcs.044610
Invadolysin is a metalloprotease conserved in many different organisms, previously shown to be essential in Drosophila with roles in cell division and cell migration. The gene...

Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells

Journal Article
Crevel, G., Hashimoto, R., Vass, S., Sherkow, J., Yamaguchi, M., Heck, M. M., & Cotterill, S. (2007)
Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells. PLOS ONE, 2(9), https://doi.org/10.1371/journal.pone.0000833
Background The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC compon...

Pre-Napier Funded Projects

  • Pump-Priming Award, BHF

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