Sharron Vass

Sharron Vass

Dr Sharron Vass BSc. Hons., PhD, FHEA

Lecturer

Biography

Dr Sharron Vass is a lecturer of Biomedical Sciences in the School of Applied Sciences, at Edinburgh Napier University, Scotland, UK.

In 2005, Dr Vass completed her Ph.D. studies in the Institute of Cell and Molecular Biology, University of Edinburgh, under the direction of Professor Margarete Heck. Her project involved investigating the molecular ‘glue’ that holds chromosomes together and what happens to chromosome structure when that glue is absent. Through this project she developed a keen interest in cell biology and a passion for fluorescence microscopy.

Dr Vass then undertook post-doctoral research at the Queen’s Medical Research Institute, University of Edinburgh, where she was involved in the study of a metalloproteinase enzyme called Invadolysin. She discovered that when the Invadolysin enzyme was ‘silenced’ in zebrafish embryos there were defects in essential cell migration processes, such as formation of blood vessels and the migration of specialised cells called neuromasts and melanophores.

Dr Vass obtained a lectureship at Edinburgh Napier University in 2014, where she established her own research group focusing on the molecular pathways regulating cell migration in cancer cells. She uses highly migratory melanoma cells and human choriocarcinoma cells as model systems, and is particularly interested in the KISS1 / KISS1R signalling cascade.

Themes

Research Areas

Esteem

Advisory panels and expert committees or witness

  • Co- Chair, Little France Post-Doctoral Society

 

Conference Activity

  • Beatson International Cancer Conference, Glasgow

 

Fellowships and Awards

  • Fellow of the Higher Education Academy

 

Invited Speaker

  • Soapbox Science - Public Engagement Event, The Mound, Edinburgh
  • Monster Confidence - STEM Promotion, Heriot Watt Uinversity, Edinburgh
  • Taking the Sticky out of Cohesion, University of Dundee
  • From Flies to Fish (via humans), Centre for Cardiovascular Research, University of Edinburgh
  • Winner - 3 Minute Thesis (2016), School of Applied Sciences, Edinburgh Napier University
  • Imaging Vascular Development and Cell Migration in Zebrafish, Karolinska Institute, Sweden
  • Linking Cell Migration and Angiogenesis in Zebrafish, University of Sheffield
  • Linking Cell Migration and Angiogenesis in Zebrafish, University of Glasgow

 

Membership of Professional Body

  • Member of British Society for Cell Biology

 

Date


15 results

A role for the metalloprotease invadolysin in insulin signaling and adipogenesis

Journal Article
Chang, C., Abhinav, K., Di Cara, F., Panagakou, I., Vass, S., & Heck, M. M. (2017)
A role for the metalloprotease invadolysin in insulin signaling and adipogenesis. Biological Chemistry, 398(3), https://doi.org/10.1515/hsz-2016-0226
Invadolysin is a novel metalloprotease conserved amongst metazoans that is essential for life in Drosophila. We previously showed that invadolysin was essential for the cell c...

Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart

Journal Article
Wilson, K. S., Baily, J., Tucker, C. S., Matrone, G., Vass, S., Moran, C., …Denvir, M. A. (2015)
Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart. Molecular and Cellular Endocrinology, 414, 120-131. https://doi.org/10.1016/j.mce.2015.07.025
Background Transient early-life perturbations in glucocorticoids (GC) are linked with cardiovascular disease risk in later life. Here the impact of early life manipulations o...

Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart

Journal Article
Wilson, K., Baily, J., Tucker, C., Vass, S., Moran, C., Chapman, K., …Denvir, M. (2015)
Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart. Heart, 101(Suppl 4), A107.3-A108. https://doi.org/10.1136/heartjnl-2015-308066.193
Introduction Foetal over-exposure to glucocorticoids (GC) has been associated with cardiovascular disorder in later life however the impact of transient early life alterations...

Invadolysin acts genetically via the SAGA complex to modulate chromosome structure

Journal Article
Janiszewski, M. M., Heck, M. M., Rao, S. G., Janiszewski, M. M., Duca, E., Nelson, B., …Heck, M. M. S. (2015)
Invadolysin acts genetically via the SAGA complex to modulate chromosome structure. Nucleic Acids Research, 43(7), 3546-3562. https://doi.org/10.1093/nar/gkv211
Identification of components essential to chromosome structure and behaviour remains a vibrant area of study. We have previously shown that invadolysin is essential in Drosoph...

Heart on a Plate: Histological and Functional Assessment of Isolated Adult Zebrafish Hearts Maintained in Culture

Journal Article
Pieperhoff, S., Wilson, K. S., Baily, J., de Mora, K., Maqsood, S., Vass, S., …Denvir, M. A. (2014)
Heart on a Plate: Histological and Functional Assessment of Isolated Adult Zebrafish Hearts Maintained in Culture. PLOS ONE, 9(5), https://doi.org/10.1371/journal.pone.0096771
The zebrafish is increasingly used for cardiovascular genetic and functional studies. We present a novel protocol to maintain and monitor whole isolated beating adult zebrafis...

Perturbation of invadolysin disrupts cell migration in zebrafish (Danio rerio)

Journal Article
Vass, S., & Heck, M. M. S. (2013)
Perturbation of invadolysin disrupts cell migration in zebrafish (Danio rerio). Experimental Cell Research, 319(8), 1198-1212. https://doi.org/10.1016/j.yexcr.2013.02.005
Invadolysin is an essential, conserved metalloprotease which links cell division with cell migration and is intriguingly associated with lipid droplets. In this work we examin...

Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling

Journal Article
Bolukbasi, E., Vass, S., Cobbe, N., Nelson, B., Simossis, V., Dunbar, D. R., & Heck, M. M. S. (2012)
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. Open Biology, 2(1), 110031-110031. https://doi.org/10.1098/rsob.110031
Multi-cellular organisms need to successfully link cell growth and metabolism to environmental cues during development. Insulin receptor–target of rapamycin (InR–TOR) signalli...

The conserved metalloprotease invadolysin localizes to the surface of lipid droplets

Journal Article
Cobbe, N., Marshall, K. M., Rao, S. G., Chang, C., Di Cara, F., Duca, E., …Heck, M. M. (2009)
The conserved metalloprotease invadolysin localizes to the surface of lipid droplets. Journal of Cell Science, 122(18), 3414-3423. https://doi.org/10.1242/jcs.044610
Invadolysin is a metalloprotease conserved in many different organisms, previously shown to be essential in Drosophila with roles in cell division and cell migration. The gene...

Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells

Journal Article
Crevel, G., Hashimoto, R., Vass, S., Sherkow, J., Yamaguchi, M., Heck, M. M., & Cotterill, S. (2007)
Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells. PLOS ONE, 2(9), https://doi.org/10.1371/journal.pone.0000833
Background The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC compon...

Metaphase Chromosome

Book Chapter
Vass, S., & Heck, M. M. (2004)
Metaphase Chromosome. In W. J. Lennarz, & M. Daniel Lane (Eds.), Encyclopedia of Biological Chemistry, 666-671. Elsevier. doi:10.1016/b0-12-443710-9/00119-8

Pre-Napier Funded Projects

  • Pump-Priming Award, BHF

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