Accute toxicity of linear alkylbenzene to Caenorhabditis elegans Maupas, 1900 in soil.
Journal Article
Johnson, S. J., Castan, M., Proudfoot, L., Barry, D. A. & Christofi, N. (2007)
Accute toxicity of linear alkylbenzene to Caenorhabditis elegans Maupas, 1900 in soil. Bulletin of Environmental Contamination and Toxicology. 79, 41-44. doi:10.1007/s00128-007-9195-6. ISSN 0007-4861
Linear alkybenzene (LAB) is a light non-aqueous phase liquid (LNAPL) whose primary use is as a precursor in the manufacture of linear alkylbenzene sulphonate (LAS) detergents....
Parasitic helminths tip the balance: potential anti-inflammatory therapies
Journal Article
Proudfoot, L. (2004)
Parasitic helminths tip the balance: potential anti-inflammatory therapies. Immunology, 113(4), 438-440. https://doi.org/10.1111/j.1365-2567.2004.01996.x
Parasitic helminths are worms that are classified within the phyla Nematoda (roundworms) and Platyhelminthes (flatworms) (see Table 1). Some nematode species, Filariae being a...
Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis
Journal Article
Keir, P. A., Brown, D. M., Clouter-Baker, A., Harcus, Y. M., & Proudfoot, L. (2004)
Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis. Parasite Immunology, 26(3), 137-139. https://doi.org/10.1111/j.0141-9838.2004.00692.x
It has been reported that excretory–secretory (ES) material from the parasitic nematode Nippostrongylus brasiliensis has potential modulatory effects on the host's immune syst...
Expression of C-Reactive Protein in Human Lung Epithelial Cells and Upregulation by Cytokines and Carbon Particles
Journal Article
Ramage, L., Proudfoot, L., & Guy, K. (2004)
Expression of C-Reactive Protein in Human Lung Epithelial Cells and Upregulation by Cytokines and Carbon Particles. Inhalation Toxicology, 16(9), 607-613. https://doi.org/10.1080/08958370490464599
C-reactive protein (CRP) is the prototypic human acute-phase protein and is found at increased levels in the blood during episodes of inflammation. CRP was generally thought t...
Anti-inflammatory responses and oxidative stress in Nippostrongylus brasiliensis-induced pulmonary inflammation.
Journal Article
McNeil, K. S., Knox, D. P. & Proudfoot, L. (2002)
Anti-inflammatory responses and oxidative stress in Nippostrongylus brasiliensis-induced pulmonary inflammation. Parasite Immunology. 24, 15-22. doi:10.1046/j.0141-9838.2001.00428.x. ISSN 0141-9838
Migration of L3 larvae of Nippostrongylus brasiliensis through the lungs of the rat, during primary infection, was studied at 24 h, 72 h and 8 days. At 24 h p.i., there was ev...
Regulation of macrophage IL-12 synthesis byLeishmania phosphoglycans
Journal Article
Piedrafita, D., Proudfoot, L., Nikolaev, A. V., Xu, D., Sands, W., Feng, G., …Liew, F. Y. (1999)
Regulation of macrophage IL-12 synthesis byLeishmania phosphoglycans. European Journal of Immunology, 29(1), 235-244. https://doi.org/10.1002/%28sici%291521-4141%28199901%2929%3A013.0.co%3B2-s
It is now generally accepted that IFN‐γ, secreted by Th1 cells, is the most potent cytokine leading to macrophage activation and host resistance against infection with the int...
Cytokines and nitric oxide as effector molecules against parasitic infections
Journal Article
Liew, F. Y., Wei, X., & Proudfoot, L. (1997)
Cytokines and nitric oxide as effector molecules against parasitic infections. Philosophical Transactions B: Biological Sciences, 352(1359), 1311-1315. https://doi.org/10.1098/rstb.1997.0115
Nitric oxide (NO) derived from L-arginine by the catalytic action of inducible NO synthase (iNOS) plays an important role in killing parasites. Many cell types express high le...
Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages
Journal Article
Proudfoot, L., Nikolaevt, A. V., Feng, G., Wei, X., Ferguson $, M. A. J., Brimacombet, J. S., …Ii, . (1996)
Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages. Proceedings of the National Academy of Sciences, 93(20), 10984-10989. https://doi.org/10.1073/pnas.93.20.10984
Lipophosphoglycan (LPG) glycoconjugates from promastigotes of Leishmania were not able to induce the expression of the cytokine-inducible nitric oxide synthase (iNOS) by the m...
Immunology of Murine Leishmaniasis
Journal Article
McSorley, S., Proudfoot, L., Agnes O 'Donnell, C., & Liew, F. (1996)
Immunology of Murine Leishmaniasis. Clinics in Dermatology, 14(5), 451-464. https://doi.org/10.1016/0738-081X%2896%2900037-5
Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major
Journal Article
Proudfoot, L., Schneider, P., Ferguson, M. A. J., & McConville, M. J. (1995)
Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major. The biochemical journal, 308(1), 45-55. https://doi.org/10.1042/bj3080045
The major macromolecule on the surface of the protozoan parasite Leishmania major is a lipophosphoglycan (LPG) which contains a glycosylphosphatidylinositol glycolipid anchor....