Deletion of endogenous Tau proteins is not detrimental in Drosophila
Journal Article
Burnouf, S., Grönke, S., Augustin, H., Dols, J., Gorsky, M. K., Werner, J., …Partridge, L. (2016)
Deletion of endogenous Tau proteins is not detrimental in Drosophila. Scientific Reports, 6, https://doi.org/10.1038/srep23102
Human Tau (hTau) is a highly soluble and natively unfolded protein that binds to microtubules within neurons. Its dysfunction and aggregation into insoluble paired helical fil...
Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease
Journal Article
Sofola, O., Kerr, F., Rogers, I., Killick, R., Augustin, H., Gandy, C., …Partridge, L. (2010)
Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease. PLoS Genetics, 6(9), https://doi.org/10.1371/journal.pgen.1001087
Aβ peptide accumulation is thought to be the primary event in the pathogenesis of Alzheimer's disease (AD), with downstream neurotoxic effects including the hyperphosphorylati...
PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3
Journal Article
Kerr, F., Rickle, A., Nayeem, N., Brandner, S., Cowburn, R. F., & Lovestone, S. (2006)
PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3. FEBS Letters, 580(13), 3121-3128. https://doi.org/10.1016/j.febslet.2006.04.064
Deregulation of PTEN/Akt signalling has been recently implicated in the pathogenesis of Alzheimer's disease (AD), but the effects on the molecular processes underlying AD path...
Actinomycete diversity associated with foaming in activated sludge plants
Journal Article
Goodfellow, M., Davenport, R., Stainsby, F. M., & Curtis, T. P. (1996)
Actinomycete diversity associated with foaming in activated sludge plants. Journal of industrial microbiology, 17(3-4), 268-280. https://doi.org/10.1007/bf01574701
Large numbers of mycolic acid-containing actinomycetes were isolated from foam and scum samples taken from three activated-sludge sewage-treatment plants using several selecti...
A method to increase silver biosorption by an industrial strain of Saccharomyces cerevisiae
Journal Article
Simmons, P., & Singleton, I. (1996)
A method to increase silver biosorption by an industrial strain of Saccharomyces cerevisiae. Applied microbiology and biotechnology, 45(1-2), 278-285. https://doi.org/10.1007/s002530050684
Ag+ biosorption by an industrial strain of Saccharomyces cerevisiae was investigated. Older (96 h old) biomass had half the biosorption capacity of younger (24 h old) biomass ...
Microbial metabolism of xenobiotics: Fundamental and applied research
Journal Article
Singleton, I. (1994)
Microbial metabolism of xenobiotics: Fundamental and applied research. Journal of Chemical Technology and Biotechnology, 59(1), 9-23. doi:10.1002/jctb.280590104
The ability of microorganisms to metabolise xenobiotic compounds has received much attention due to the environmental persistence and toxicity of these chemicals. The microbia...
Cloning of putative nicotinic acetylcholine receptor genes from the locust
Journal Article
MARSHALL, J., DARLISON, M. G., LUNT, G. G., & BARNARD, E. A. (1988)
Cloning of putative nicotinic acetylcholine receptor genes from the locust. Biochemical Society Transactions, 16(4), 463-465. https://doi.org/10.1042/bst0160463
No abstract available.