The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy
Journal Article
Biskou, O., Casanova, V., Hooper, K., Kemp, S., Wright, G. P., Satsangi, J., …Stevens, C. (2019)
The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE, 14(1), https://doi.org/10.1371/journal.pone.0209665
The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes includi...
Antiviral therapeutic approaches for human rhinovirus infections
Journal Article
Casanova, V., Sousa, F. H., Stevens, C., & Barlow, P. G. (2018)
Antiviral therapeutic approaches for human rhinovirus infections. Future Virology, https://doi.org/10.2217/fvl-2018-0016
Human rhinoviruses (RV) are the primary etiological agent of the common cold. This infection can be mild and self-limiting in immunocompetent hosts, but can be associated wit...
Cathelicidins display conserved direct antiviral activity towards rhinovirus.
Journal Article
Sousa, F. H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., …Barlow, P. G. (2017)
Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides, 95, 76-83. https://doi.org/10.1016/j.peptides.2017.07.013
Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised ind...
Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer
Journal Article
Mathur, S., Mincher, D., Turnbull, A., Stevens, C., & Poole, A. (2016)
Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer. European Journal of Cancer, 61, S142. https://doi.org/10.1016/s0959-8049%2816%2961501-0
Background: In spite of major advances in the diagnosis and treatment of cancer, there remains a paucity of biomarkers for early detection. Legumain is a potential cancer biom...
Inflammatory Bowel Disease Drugs: A Focus on Autophagy
Journal Article
Hooper, K. M., Barlow, P. G., Stevens, C., & Henderson, P. (2017)
Inflammatory Bowel Disease Drugs: A Focus on Autophagy. Journal of Crohn's and Colitis, 11(1), 118-127. https://doi.org/10.1093/ecco-jcc/jjw127
Inflammatory bowel disease [IBD] is characterized by chronic inflammation of the gastrointestinal tract. Medications such as corticosteroids, thiopurines, immunomodulators and...
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Journal Article
Baghdiguian, S., Bagniewska-Zadworna, A., Baek, S., Baehrecke, E. H., Bae, S. H., Bae, D., …Stevens, C. (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), 1-222. https://doi.org/10.1080/15548627.2015.1100356
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientis...
PWE-090 the effect of commonly used Ibd drugs on autophagy induction using an in vitro cell culture system.
Journal Article
Henderson, P., Satsangi, J., Wilson, D., & Stevens, C. (2014)
PWE-090 the effect of commonly used Ibd drugs on autophagy induction using an in vitro cell culture system. Gut, 63(Suppl 1), A163. https://doi.org/10.1136/gutjnl-2014-307263.350
Introduction Genome wide association studies and functional experiments in inflammatory bowel disease (IBD) have delineated the importance of autophagy in IBD pathogenesis. We...
A role for vimentin in Crohn disease
Journal Article
Henderson, P., Wilson, D. C., Satsangi, J., & Stevens, C. (2012)
A role for vimentin in Crohn disease. Autophagy, 8(11), 1695-1696. https://doi.org/10.4161/auto.21690
Crohn disease (CD), one of the major chronic inflammatory bowel diseases, occurs anywhere in the gastrointestinal tract with discontinuous transmural inflammation. A number of...
The Role of Autophagy in Crohn’s Disease
Journal Article
Henderson, P., & Stevens, C. (2012)
The Role of Autophagy in Crohn’s Disease. Cells, 1(3), 492-519. https://doi.org/10.3390/cells1030492
(Macro)-autophagy is a homeostatic process by which eukaryotic cells dispose of protein aggregates and damaged organelles. Autophagy is also used to degrade micro-organisms th...
TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's Disease
Journal Article
Nimmo, E. R., Stevens, C., Phillips, A. M., Smith, A., Drummond, H. E., Noble, C. L., …Satsangi, J. (2011)
TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's Disease. Gastroenterology, 141(3), 972-981.e2. https://doi.org/10.1053/j.gastro.2011.05.043
Background & Aims The mechanisms by which specific mutations in NOD2/CARD15 increase the risk for Crohn's disease (CD) are unclear. We identified proteins that interact with {...