The use of ozone in the remediation of polycyclic aromatic hydrocarbon contaminated soil.
Journal Article
O’Mahony, M. M., Dobson, A. D., Barnes, J. D., & Singleton, I. (2006)
The use of ozone in the remediation of polycyclic aromatic hydrocarbon contaminated soil. Chemosphere, 63(2), 307-314. https://doi.org/10.1016/j.chemosphere.2005.07.018
The potential of using ozone for the removal of phenanthrene from several different soils, both alone and in combination with biodegradation using a microbial inoculant (Pseud...
Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells
Journal Article
Hillier, S. G., Rae, M. T., Niven, D., Critchley, H. O. D., & Harlow, C. R. (2004)
Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells. Journal of Clinical Endocrinology and Metabolism, 89(9), 4538-4544. https://doi.org/10.1210/jc.2003-032225
The human ovarian surface epithelium (OSE) is subject to
serial injury and repair during ovulation, which is a natural inflammatory event. We asked whether there is a compensa...
Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation
Journal Article
Wilson, M. R., Foucaud, L., Barlow, P. G., Hutchison, G. R., Sales, J., Simpson, R. J., & Stone, V. (2007)
Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation. Toxicology and Applied Pharmacology, 225(1), 80-89. https://doi.org/10.1016/j.taap.2007.07.012
Particulate air pollution (PM10) consists of a mixture of components, including nanoparticles and metals. Studies from our laboratory have demonstrated that transition metals ...
Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents.
Journal Article
Dias, N., Goossens, J., Baldeyrou, B., Lansiaux, A., Colson, P., Di Salvo, A., …Bailly, C. (2005)
Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents. Bioconjugate Chemistry, 16(4), 949-958. https://doi.org/10.1021/bc050065x
We report the synthesis of an original series of oxoazabenzo[de]anthracenes conjugated to an amino acid: Ala, Phe, Pro, Lys, or Gly (4a-e, respectively). The compounds, derive...
Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential
Journal Article
Sharma, A., Goring, A., Staines, K., Emery, R., Pitsillides, A. A., Oreffo, R. O., …Clarkin, C. E. (2020)
Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential. Matrix Biology Plus, 5, https://doi.org/10.1016/j.mbplus.2019.100018
Mineralization of bone is achieved by the sequential maturation of the immature amorphous calcium phase to mature hydroxyapatite and is central to the process of bone developm...
The Structure of Escherichia coli ATP-phosphoribosyltransferase: Identification of Substrate Binding Sites and Mode of AMP Inhibition
Journal Article
Lohkamp, B., McDermott, G., Campbell, S. A., Coggins, J. R., & Lapthorn, A. J. (2004)
The Structure of Escherichia coli ATP-phosphoribosyltransferase: Identification of Substrate Binding Sites and Mode of AMP Inhibition. Journal of Molecular Biology, 336(1), 131-144. https://doi.org/10.1016/j.jmb.2003.12.020
ATP-phosphoribosyltransferase (ATP-PRT), the first enzyme of the histidine pathway, is a complex allosterically regulated enzyme, which controls the flow of intermediates thro...
Generation of “Neoheparin” from E. coli K5 Capsular Polysaccharide
Journal Article
Lindahl, U., Li, J., Kusche-Gullberg, M., Salmivirta, M., Alaranta, S., Veromaa, T., …Casu, B. (2005)
Generation of “Neoheparin” from E. coli K5 Capsular Polysaccharide. Journal of Medicinal Chemistry, 48(2), 349-352. https://doi.org/10.1021/jm049812m
Heparin remains a major drug in prevention of thromboembolic disease. Concerns related to its animal source have prompted search for heparin analogues. The anticoagulant activ...
Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression
Journal Article
Gordon, K., Clouaire, T., Bao, X. X., Kemp, S. E., Xenophontos, M., de Las Heras, J. I., & Stancheva, I. (2014)
Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression. Nucleic Acids Research, 42(6), 3529-3541. https://doi.org/10.1093/nar/gkt1351
Tumourigenic transformation of normal cells into cancer typically involves several steps resulting in acquisition of unlimited growth potential, evasion of apoptosis and non-r...
Hydrogenases in Desulfovibrio vulgaris Hildenborough: structural and physiologic characterisation of the membrane-bound [NiFeSe] hydrogenase
Journal Article
Valente, F. M. A., Oliveira, A. S. F., Gnadt, N., Pacheco, I., Coelho, A. V., Xavier, A. V., …Pereira, I. A. C. (2005)
Hydrogenases in Desulfovibrio vulgaris Hildenborough: structural and physiologic characterisation of the membrane-bound [NiFeSe] hydrogenase. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 10(6), 667-682. https://doi.org/10.1007/s00775-005-0022-4
The genome of Desulfovibrio vulgaris Hildenborough (DvH) encodes for six hydrogenases (Hases), making it an interesting organism to study the role of these proteins in sulphat...
Impact of low-level atmospheric ozone-enrichment on black spot and anthracnose rot of tomato fruit
Journal Article
Tzortzakis, N., Singleton, I., & Barnes, J. (2008)
Impact of low-level atmospheric ozone-enrichment on black spot and anthracnose rot of tomato fruit. Postharvest Biology and Technology, 47(1), 1-9. https://doi.org/10.1016/j.postharvbio.2007.06.004
Tomato fruit (Lycopersicon esculentum L.) were exposed to ozone concentrations between 0.005 (control) and 5.0 μmol mol−1 up to 13 days at 13 °C, prior to, or following, inocu...