Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells
Journal Article
Hillier, S. G., Rae, M. T., Niven, D., Critchley, H. O. D., & Harlow, C. R. (2004)
Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells. Journal of Clinical Endocrinology and Metabolism, 89(9), 4538-4544. https://doi.org/10.1210/jc.2003-032225
The human ovarian surface epithelium (OSE) is subject to
serial injury and repair during ovulation, which is a natural inflammatory event. We asked whether there is a compensa...
Anti-inflammatory steroid signalling in the human peritoneum
Journal Article
Fegan, K. S., Rae, M. T., Critchley, H. O. D., & Hillier, S. G. (2008)
Anti-inflammatory steroid signalling in the human peritoneum. Journal of Endocrinology, 196, 369-376. https://doi.org/10.1677/JOE-07-0419
Peritoneal surface epithelial (PSE) cells participate in adhesion formation following inflammatory injury yet adjacent ovarian SE (OSE) cells regenerate without scarification ...
Design of hypoxia-targeting radiopharmaceuticals: selective uptake of copper-64 complexes in hypoxic cells in vitro
Journal Article
Dearling, J. L. J., Lewis, J. S., Mullen, G. E. D., Rae, M. T., Zweit, J., & Blower, P. J. (1998)
Design of hypoxia-targeting radiopharmaceuticals: selective uptake of copper-64 complexes in hypoxic cells in vitro. European Journal of Nuclear Medicine and Molecular Imaging, 25(7), 788-792. https://doi.org/10.1007/s002590050283
The well-known perfusion tracer CuPTSM, labelled with 62Cu or 64Cu, is believed to be trapped in cells non-selectively by a bioreductive mechanism. It is proposed that by modi...
Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis.
Journal Article
Rae, M. T., Niven, D., Ross, A., Forster, T., Lathe, R., Critchley, H. O. D., …Hillier, S. G. (2004)
Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis. Journal of Endocrinology, 183, 19-28. https://doi.org/10.1677/joe.1.05754
The human ovarian surface epithelium (HOSE) is a common site of gynaecological disease including endometriosis and ovarian cancer, probably due to serial injury-repair events ...
Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells
Journal Article
Rae, M. T., Price, D., Harlow, C. R., Critchley, H. O. D., & Hillier, S. G. (2009)
Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells. Fertility and Sterility, 92(2), 703-708. https://doi.org/10.1016/j.fertnstert.2008.06.040
Objective
To obtain proof-of-concept that locally produced anti-inflammatory steroids suppress ovulation-associated extracellular matrix proteases in human ovarian surface epi...
The effects of undernutrition, in utero, on reproductive function in adult male and female sheep
Journal Article
Rae, M., Kyle, C., Miller, D., Hammond, A., Brooks, A., & Rhind, S. (2002)
The effects of undernutrition, in utero, on reproductive function in adult male and female sheep. Animal Reproduction Science, 72(1-2), 63-71. https://doi.org/10.1016/S0378-4320%2802%2900068-4
The aim of this study was to determine the effects of maternal undernutrition during pregnancy on adult reproductive function in male and female offspring. Groups of ewes were...
Steroid signalling in the ovarian surface epithelium
Journal Article
Rae, M. T., & Hillier, S. G. (2005)
Steroid signalling in the ovarian surface epithelium. Trends in Endocrinology and Metabolism, 16(7), 327-333. https://doi.org/10.1016/j.tem.2005.07.002
Human ovarian surface epithelium (HOSE) undergoes serial injury-repair with each ovulation, which is probably why most ovarian epithelial cancers arise there. Considering the ...
The Pancreas Is Altered by In Utero Androgen Exposure: Implications for Clinical Conditions Such as Polycystic Ovary Syndrome (PCOS)
Journal Article
Franks, S., Rae, M. T., Grace, C., Hogg, K., Wilson, L. M., McHaffie, S. L., …Duncan, C. (2013)
The Pancreas Is Altered by In Utero Androgen Exposure: Implications for Clinical Conditions Such as Polycystic Ovary Syndrome (PCOS). PLOS ONE, 8(2), https://doi.org/10.1371/journal.pone.0056263
Using an ovine model of polycystic ovary syndrome (PCOS), (pregnant ewes injected with testosterone propionate (TP) (100 mg twice weekly) from day (d)62 to d102 of d147 gestat...
Cortisol Inactivation by 11β-Hydroxysteroid dehydrogenase-2 May Enhance Endometrial Angiogenesis via Reduced Thrombospondin-1 in Heavy Menstruation
Journal Article
Rae, M. T., Mohamad, A., Price, D., Hadoke, P. W. F., Walker, B. R., Mason, J. I., …Critchley, H. O. D. (2009)
Cortisol Inactivation by 11β-Hydroxysteroid dehydrogenase-2 May Enhance Endometrial Angiogenesis via Reduced Thrombospondin-1 in Heavy Menstruation. Journal of Clinical Endocrinology and Metabolism, 94, 1443-1450. https://doi.org/10.1210/jc.2008-1879
Context: Heavy menstrual bleeding (HMB; menorrhagia) impairs quality of life for women and requires medication or surgery. Because glucocorticoids inhibit angiogenesis in othe...
Maternal undernutrition does not alter Sertoli cell numbers or the expression of key developmental markers in the mid-gestation ovine fetal testis
Journal Article
Andrade, L. P., Rhind, S. M., Rae, M. T., Kyle, C. E., Jowett, J., & Lea, R. G. (2013)
Maternal undernutrition does not alter Sertoli cell numbers or the expression of key developmental markers in the mid-gestation ovine fetal testis. Journal of Negative Results in BioMedicine, 12(1), https://doi.org/10.1186/1477-5751-12-2
Background
The aim of this study was to determine the effects of maternal undernutrition on ovine fetal testis morphology and expression of relevant histological indicators. M...