Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., …Florida-James, G. D. (2017). Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, doi:10.1152/ajpheart.00592.2017. ISSN 0363-6135
Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, p...
Xue, S., Gao, L., Ahmadi, M., Ghorashian, S., Barros, R. D., Pospori, C., …Stauss, H. J. (2012). Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo. OncoImmunology. 2(1), e22590. doi:10.4161/onci.22590. ISSN 2162-4011
In this study, we generated human MHC Class I-restricted CD4+ T cells specific for Epstein-Barr virus (EBV) and cytomegalovirus (CMV), two herpesviridae associated with lympho...
Ahmadi, M., King, J. W., Xue, S. A., Voisine, C., Holler, A., Wright, G. P., …Stauss, H. J. (2011). CD3 limits the efficacy of TCR gene therapy in vivo. Blood. 118(13), 3528-3537. doi:10.1182/blood-2011-04-346338. ISSN 0006-4971
The function of T-cell receptor (TCR) gene
modified T cells is dependent on efficient
surface expression of the introduced
TCR / heterodimer. We tested whether
Wright, G. P., Stauss, H. J. & Ehrenstein, M. R. (2011). Therapeutic potential of Tregs to treat rheumatoid arthritis. Seminars in Immunology. 23(3), 195-201. doi:10.1016/j.smim.2011.07.004. ISSN 1044-5323
There is accumulating evidence for regulatory T cell defects in rheumatoid arthritis and that some biologic interventions, in particular anti-TNF, can target this population. ...
Kinloch, A. J., Ng, K. & Wright, G. P. (2011). Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies. Recent patents on inflammation & allergy drug discovery. 5(2), 108-127. doi:10.2174/187221311795399246. ISSN 1872-213X
Rheumatoid arthritis (RA), although widely considered to be the most commonly occurring autoimmune disease, has only truly been substantiated as a distinct autoimmune disease ...
Notley, C. A., Brown, M. A., Wright, G. P. & Ehrenstein, M. R. (2011). Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells. The journal of immunology : official journal of the American Association of Immunologists. 186(8), 4967-4972. doi:10.4049/jimmunol.1003021. ISSN 1550-6606
The clearance of dying cells is vital for re-establishing tolerance during inflammation and has potent immunoregulatory consequences. Because natural IgM plays a key role in t...
Wright, G. P., Notley, C. A., Xue, S. A., Bendle, G. M., Holler, A., Schumacher, T. N., …Stauss, H. J. (2009). Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. Proceedings of the National Academy of Sciences. 106(45), 19078-19083. doi:10.1073/pnas.0907396106. ISSN 0027-8424
Regulatory T cells (Tregs) can suppress a wide range of immune cells, making them an ideal candidate for the treatment of autoimmunity. The potential clinical translation of t...
Scottish Funding Council
Ranking novel immune-modulating therapeutics for progression to clinical development
My main area of research interest is the role of exercise and ageing on vitamin D metabolism. Scotland is identified as a vitamin D deficient nation...