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Edinburgh Napier University

Graham Wright

Graham Wright

Dr Graham Wright PhD

Lecturer

g.wright2@napier.ac.uk

About me
Activity
Outputs
Projects
Post Grad

School

School of Applied Sciences

Esteem

Reviewing

International Journal of Clinical Rheumatology – Future Medicine
Gene Therapy – Nature Publishing Group
Biologics: Targets and Therapy – Dove Medical Press
Arthritis and Rheumatism – Wiley
Rheumatology: Research and Reviews – Dove Medical Press
OncoTargets and Therapy – Dove Medical Press

Invited Speaker

Arthritis Research UK Fellows Conference
UCL Partners Conference– Invited Speaker
British Society of Gene Therapy

Fellowships and Awards

ARUK Fellows Prize – Best Presentation

Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men

Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., …Florida-James, G. D. (2017). Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, doi:10.1152/ajpheart.00592.2017. ISSN 0363-6135
<p>Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., …Florida-James, G. D. (2017). Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. <i>American journal of physiology. Heart and circulatory physiology</i>, doi:10.1152/ajpheart.00592.2017. ISSN 0363-6135</p>

Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, p...

2017
Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo

Xue, S., Gao, L., Ahmadi, M., Ghorashian, S., Barros, R. D., Pospori, C., …Stauss, H. J. (2012). Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo. OncoImmunology. 2(1), e22590. doi:10.4161/onci.22590. ISSN 2162-4011
<p>Xue, S., Gao, L., Ahmadi, M., Ghorashian, S., Barros, R. D., Pospori, C., …Stauss, H. J. (2012). Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo. <i>OncoImmunology.</i> <i>2</i>(1), e22590. doi:10.4161/onci.22590. ISSN 2162-4011</p>

In this study, we generated human MHC Class I-restricted CD4+ T cells specific for Epstein-Barr virus (EBV) and cytomegalovirus (CMV), two herpesviridae associated with lympho...

2012
CD3 limits the efficacy of TCR gene therapy in vivo.

Ahmadi, M., King, J. W., Xue, S. A., Voisine, C., Holler, A., Wright, G. P., …Stauss, H. J. (2011). CD3 limits the efficacy of TCR gene therapy in vivo. Blood. 118(13), 3528-3537. doi:10.1182/blood-2011-04-346338. ISSN 0006-4971
<p>Ahmadi, M., King, J. W., Xue, S. A., Voisine, C., Holler, A., Wright, G. P., …Stauss, H. J. (2011). CD3 limits the efficacy of TCR gene therapy in vivo. <i>Blood</i>. <i>118</i>(13), 3528-3537. doi:10.1182/blood-2011-04-346338. ISSN 0006-4971</p>

The function of T-cell receptor (TCR) gene modified T cells is dependent on efficient surface expression of the introduced TCR / heterodimer. We tested whether endogenous CD3...

2011
Therapeutic potential of Tregs to treat rheumatoid arthritis

Wright, G. P., Stauss, H. J. & Ehrenstein, M. R. (2011). Therapeutic potential of Tregs to treat rheumatoid arthritis. Seminars in Immunology. 23(3), 195-201. doi:10.1016/j.smim.2011.07.004. ISSN 1044-5323
<p>Wright, G. P., Stauss, H. J. & Ehrenstein, M. R. (2011). Therapeutic potential of Tregs to treat rheumatoid arthritis. <i>Seminars in Immunology.</i> <i>23</i>(3), 195-201. doi:10.1016/j.smim.2011.07.004. ISSN 1044-5323</p>

There is accumulating evidence for regulatory T cell defects in rheumatoid arthritis and that some biologic interventions, in particular anti-TNF, can target this population. ...

2011
Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies

Kinloch, A. J., Ng, K. & Wright, G. P. (2011). Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies. Recent patents on inflammation & allergy drug discovery. 5(2), 108-127. doi:10.2174/187221311795399246. ISSN 1872-213X
<p>Kinloch, A. J., Ng, K. & Wright, G. P. (2011). Clinical Applications of Autoimmunity to Citrullinated Proteins in Rheumatoid Arthritis, from Improving Diagnostics to Future Therapies. <i>Recent patents on inflammation & allergy drug discovery.</i> <i>5</i>(2), 108-127. doi:10.2174/187221311795399246. ISSN 1872-213X</p>

Rheumatoid arthritis (RA), although widely considered to be the most commonly occurring autoimmune disease, has only truly been substantiated as a distinct autoimmune disease ...

2011
Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells

Notley, C. A., Brown, M. A., Wright, G. P. & Ehrenstein, M. R. (2011). Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells. The journal of immunology : official journal of the American Association of Immunologists. 186(8), 4967-4972. doi:10.4049/jimmunol.1003021. ISSN 1550-6606
<p>Notley, C. A., Brown, M. A., Wright, G. P. & Ehrenstein, M. R. (2011). Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells. <i>The journal of immunology : official journal of the American Association of Immunologists.</i> <i>186</i>(8), 4967-4972. doi:10.4049/jimmunol.1003021. ISSN 1550-6606</p>

The clearance of dying cells is vital for re-establishing tolerance during inflammation and has potent immunoregulatory consequences. Because natural IgM plays a key role in t...

2011
Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

Wright, G. P., Notley, C. A., Xue, S. A., Bendle, G. M., Holler, A., Schumacher, T. N., …Stauss, H. J. (2009). Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. Proceedings of the National Academy of Sciences. 106(45), 19078-19083. doi:10.1073/pnas.0907396106. ISSN 0027-8424
<p>Wright, G. P., Notley, C. A., Xue, S. A., Bendle, G. M., Holler, A., Schumacher, T. N., …Stauss, H. J. (2009). Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis. <i>Proceedings of the National Academy of Sciences.</i> <i>106</i>(45), 19078-19083. doi:10.1073/pnas.0907396106. ISSN 0027-8424</p>

Regulatory T cells (Tregs) can suppress a wide range of immune cells, making them an ideal candidate for the treatment of autoimmunity. The potential clinical translation of t...

2009

Ranking novel immune-modulating therapeutics for progression to clinical development

Scottish Funding Council

Ranking novel immune-modulating therapeutics for progression to clinical development

2018 to 2018

Pre-Napier Funded Projects

Engineered Treg Therapy for Multiple Sclerosis - Wellcome Trust – Pathfinder Award (Co-PI) Award £242000, 2015 (University College London)
Generating Ag-specific regulatory T cells for the treatment of autoimmune disease – MRC – Bench to Bedside PhD Studentship (Award holder/PhD student) £81000 (University College London)
Generating ‘designer’ Tregs for the treatment of Rheumatoid Arthritis – Arthritis Research UK – Fellowship (PI) £238000 (University College London)

Current Post Grad projects

Previous Post Grad projects

Cationic Host Defence Peptides as novel therapeutics for Chlamydia infection - Beatriz Cozar Fernandez, Dr Peter Barlow, Dr Nick Wheelhouse, Dr Graham Wright

Master's Degree

2016 to date

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