Lorna Proudfoot
Lorna Proudfoot

Dr Lorna Proudfoot

Lecturer

 0131 455 2574

  l.proudfoot@napier.ac.uk

  

Biography

I graduated from Glasgow University in 1991 from the Department of Biochemistry with a PhD entitled 'Dynamic aspects of the nematode surface'. I then moved on to Dundee University Biochemistry Department for my first post-doctoral research where I studied parasite glycoconjugates with Prof Mike Ferguson and Dr Malcolm McConville. My second post-doc was with Professor Eddy Liew at the Department of Immunology, Glasgow University in 1993 where I investigated the effect of Leishmania parasite glycoconjugates on the innate immune system and production of nitric oxide. In 1996 I became a lecturer here at the School of Applied Sciences.

School

Research Groups

Themes

Esteem

Advisory panels and expert committees or witness

  • SQA (QAA) National Validation - Chair of the HN Group Award Validation of the HND Applied Biological Sciences, June 2005.

 

Conference/Workshop

  • Nanotox 2010, Edinburgh Napier University

 

External Examining/Validations

  • PhD External Examiner, Glasgow University Claire Roberts. Biophysical properties of the nematode surface.
  • PhD External Examiner, Edinburgh University Glyn Ball. An evaluation of the Nippostrongylus brasiliensis infection in the rat as a model for the development of subunit vaccines against nematode parasites of ruminants.

 

Fellowships and Awards

  • Fellow of the Higher Education Academy

 

Grant Reviewer

  • Reviewer for Research Grants: Medical Research Council, BBSRC, Broad Foundation, SPARC (EPSRC & BBSRC), NWO-nano Technology foundation STW (Netherlands).

 

Invited Speaker

  • NanoImpactNet Q-Nano, University College Dublin
  • British Society for Parasitology, Edinburgh University Oral presentation in the ‘Immunomodulation by Helminths’ session
  • Inflammation and Inflammatory Disease, Royal Society of Edinburgh

 

Public Engagement Activity

  • Edinburgh International Science Festival, April 2011. FluFighters, Discover Science event at the Museum of Scotland

 

Reviewing

  • Reviewer for Research Journals: Immunology, Clinical and Experimental Immunology, Parasite Immunology, Parasitology Research, European Journal of Medicinal Chemistry.

 

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Date


24 results

Glycoinositolphospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages

Journal Article
Proudfoot, L., O'Donnell, C. A., & Liew, F. Y. (1995)
Glycoinositolphospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages. European Journal of Immunology, 25(3), 745-750. https://doi.org/10.1002/eji.1830250318
Murine macrophages express high levels of inducible nitric oxide (NO) synthase and produce large amounts of nitric oxide when activated with interferon-gamma and lipopolysacch...

External stimuli and intracellular signalling in the modification of the nematode surface during transition to the mammalian host environment

Journal Article
Proudfoot, L., Kusel, J. R., Smith, H. V., & Kennedy, M. W. (1993)
External stimuli and intracellular signalling in the modification of the nematode surface during transition to the mammalian host environment. Parasitology, 107(05), 559. https://doi.org/10.1017/s0031182000068141
Previous work has shown that the surface of infective larvae of parasitic nematodes will not bind the fluorescent lipid analogue 5-N(octadecanoyl)aminofluorescein (AF18) until...

Rapid changes in the surface of parasitic nematodes during transition from pre- to post-parasitic forms

Journal Article
Proudfoot, L., Kusel, J. R., Smith, H. V., Harnett, W., Worms, M. J., & Kennedy, M. W. (1993)
Rapid changes in the surface of parasitic nematodes during transition from pre- to post-parasitic forms. Parasitology, 107(01), 107. doi:10.1017/s0031182000079464
All mammalian-parasitic stages of a range of nematode species investigated (Brugia pahangi, Acanthocheilonema viteae, Strongyloides ratti, Nippostrongylus brasiliensis, Trichi...

The surface lipid of parasitic nematodes: Organization, and modifications during transition to the mammalian host environment

Journal Article
Proudfoot, L., Kusel, J. R., Smith, H. V., Harnett, W., Worms, M. J., & Kennedy, M. W. (1990)
The surface lipid of parasitic nematodes: Organization, and modifications during transition to the mammalian host environment. Acta tropica, 47(5-6), 323-330. https://doi.org/10.1016/0001-706x%2890%2990033-v
The biophysical properties of the surface lipid of a range of nematode species and their developmental stages were examined, using fluorescent lipid probes and fluorescence re...

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