Nick Wheelhouse

Nick Wheelhouse

Dr Nick Wheelhouse BSc (Hons) PhD

Associate Professor

Biography

Associate Professor and Research Group Lead in Microbiology within the School of Applied Sciences at Edinburgh Napier University.

I started my academic career as a Postdoctoral Research Fellow in the Department of Pathology at Edinburgh University where I worked in the areas of liver cancer and transplantation failure. It was here that I developed a keen interest in understanding the underlying causes of disease pathogenesis. I then moved to the Moredun Research Institute where I worked first as a Postdoctoral scientist and then as as Senior Postdoctoral Scientist focusing my research into the effects and impacts of bacterial infections which cause reproductive complications in both humans and livestock.

I am a member of Edinburgh Infectious Diseases, the hub for infectious disease research in Edinburgh, a Council member for the Society for Reproduction and Fertility, a member of the Microbiology Society and a Fellow of the Higher Education Academy. I also act as an Associate Editor on Frontiers in Veterinary Science and more recently Reproduction and Fertility.

My main areas of research are the diagnosis, immunopathogenesis and epidemiology of reproductive infections. I am particularly interested in chlamydial infections of humans and animals, and more recently neglected zoonotic causes of non-malarial fevers and livestock infertility in sub-Saharan Africa including Q-fever and Brucellosis.

My work involves collaboration with multiple partner organisations including The Centre for Reproductive Health, at the University of Edinburgh, NHS Lothian and the Institute of Biodiversity Animal Health and Comparative Medicine at the University of Glasgow in the UK where I hold a position as an Affiliated Researcher. Internationally I have developed strong links with Kwame Nkrumah University of Science and Technology in Ghana, The University of Nairobi in Kenya and the University of Campinas in Brazil.

Themes

Esteem

Advisory panels and expert committees or witness

  • Committee member Food Standards Agency Joint Expert Group on Animal Feed and Feed Additives - AFFAJEG
  • Network Lead- Animal Health & Greenhouse Gas Emissions Intensity Network
  • Council member- Society for Reproduction and Fertility
  • Royal Society of Biology Animal Science Group
  • International External advisor for the Instituto Nacional de Tecnologia Agropecuaria (INTA) in Argentina (2015-)
  • Expert of Science and Technology Evaluation- National Center of Science and Technology Evaluation, Kazakhstan

 

Conference Organising Activity

  • Conference Presentation: Fertility 2022
  • Judging panel SRF Posters and 'Postdoctoral presentation' session Fertility 2022
  • Judging panel 'Postgraduate presentation' Fertility 2021
  • Conference Presentation: Fertility 2021, Online
  • Royal Society Westminster Pairing
  • Judging panel 'Postgraduate presentation' and 'Postdoctoral presentation' sessions Fertility 2020
  • Session Chair (Fertility 2020)
  • Workshop organiser: KNUST, Kumasi, Ghana
  • Judging panel 'Best Poster' and 'ECR presentation' Fertility 2019, Birmingham
  • Conference Presentation: Fertility 2018, Liverpool
  • Conference Presentation: European Society for Coxiellosis, Chlamydioses, Anaplasmoses and Rickettsioses, Marseille,
  • Conference presentation: European Society for Chlamydia Research, Cambridge
  • Conference Presentation: SRF annual meeting, Cambridge
  • Conference Presentation: Edinburgh Infectious Diseases Symposium, 2015
  • Conference Presentation: European Meeting for Animal Chlamydioses, Paris
  • Conference Presentation: European Meeting for Animal Chlamydioses, Jena
  • Conference Presentation: European Society for Chlamydia Research, Amsterdam
  • Conference Presentation: FEMAC meeting, Murcia, 2009
  • Conference Presentation: European Society for Chlamydia Research, Aarhus, Denmark
  • Conference Presentation: COST855 meeting Pulawy, Poland
  • Conference Presentation: COST855 meeting, Edinburgh
  • Conference Presentation: British Society for Immunology, Glasgow
  • Conference Presentation: British Society for Nutrition, Glasgow
  • Conference Presentation: British Society of Animal Science, Scarborough

 

Editorial Activity

  • Associate Editor Veterinary Sciences
  • Reproduction & Fertility- Associate Editor
  • Frontiers in Veterinary Science- Associate Editor
  • Editorial Board Member 'Frontiers in Microbiology'
  • Associate Editor 'Heliyon' Elsevier

 

External Examining/Validations

  • The Royal Veterinary College- External Examiner

 

Grant Funding Panel Member

  • SRF- Grant awarding committee

 

Grant Reviewer

  • The University of Veterinary Medicine Vienna 'Top Vet Science' call
  • Assessor Innovate UK
  • Research Foundation- Flanders (FWO) Grant Reviewer
  • BBSRC Grant Reviewer
  • The German Israeli Foundation for Scientific Research and Development
  • MRC Grant Reviewer
  • National Science Foundation (US)

 

Invited Speaker

  • Invited Speaker: SRF Early Career Research Workshop, Edinburgh
  • Acceptability of Extragenital Chlamydia testing in young women- NHS Research Scotland Annual Conference
  • Invited Speaker: Kwame Nkrumah University of Science and Technology, Kumasi, Ghaa
  • Invited Speaker: Kumasi Centre for Collaborative Research, Kumasi, Ghana
  • 'Q-fever' Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow
  • Invited talk: School of Life Sciences, Edinburgh Napier University
  • Sheep Veterinary Society meeting, Jersey 2010 ‘Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion’
  • FACCE JPI MACSUR LiveM meeting Potsdam, June 2016 'Animal Health and Greenhouse Gas Emissions Network: Achievements and Future'
  • Global Research Alliance on climate change meeting Reading, June 2015. ‘Investigations into novel pathogens associated with bovine reproductive failure’.

 

Media Activity

  • Q-fever podcast- Veterinary times
  • The Sheep Farmer March/ April 2012 ‘Controlling chlamydial abortion’
  • ‘Chlamydial infection of sheep an infectious cause of prenatal lamb death’ http://www.knowledgescotland.org/briefings.php?id=209
  • The Sheep Farmer July/Aug 2010 ‘Chlamydial abortion’
  • The Crofter Issue 88 Aug 2010 ‘Controlling chlamydial abortion in sheep’

 

Membership of Professional Body

  • Fellow of the Higher Education Academy

 

Public Engagement Activity

  • National Sheep Association (NSA) Scotsheep 2010
  • Moredun Animal Health Roadshow (Peebles) 2011
  • NSA National Event 2010
  • Royal Highland Show 2010
  • Royal Highland Show 2013
  • NSA Scotsheep 2011
  • Royal Highland Show 2011

 

Research Degree External Examining

  • External PhD examination University of Southampton 'Studies on the plasmid-based genetic tools for C. muridarum: progress towards a replicating vector for transposon mutagenesis'
  • University College Dublin PhD examiner 'Bovine sperm sexing impacts sperm morphokinetics, gameto-maternal interaction and subsequent early embryonic development'

 

Reviewing

  • Epidemiology and infection
  • Journal of Zoo and Wildlife Medicine
  • Frontiers in Microbiology
  • Transboundary and Emerging Diseases
  • Veterinary Pathology
  • BMC Veterinary Research
  • Emerging Infectious Diseases
  • Veterinary Microbiology
  • Veterinary Journal
  • Veterinary Record
  • PeerJ
  • Chemistry & Biology
  • Microbes & infection
  • Pathogens & disease
  • Veterinary Immunology & Immunopathology

 

Visiting Positions

  • Glasgow University IBACHM- Affiliate Researcher
  • Guest Lecturer- University of Liverpool Veterinary School

 

Date


73 results

Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease

Journal Article
Turin, L., Surini, S., Wheelhouse, N., & Silvia Rocchi, M. (2022)
Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease. Veterinary Research, 53(1), Article 37. https://doi.org/10.1186/s13567-022-01052-x
Environmental transmission of Chlamydia abortus as a result of enzootic disease or disease outbreaks and the threats posed by this pathogen has been previously reported, howev...

Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle

Journal Article
Wheelhouse, N., Hearn, J., Livingstone, M., Flockhart, A., Dagleish, M., & Longbottom, D. (2022)
Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle. Journal of Applied Microbiology, 132(4), 2642-2648. https://doi.org/10.1111/jam.15422
Aims The order Chlamydiales comprises a broad range of bacterial pathogens and endosymbionts, which infect a wide variety of host species. Within this order, members of the fa...

Q fever and early pregnancy failure: a Scottish case control study

Journal Article
Wheelhouse, N., Kemp, S., Halliday, J. E. B., Tingas, E. A., Duncan, W. C., & Horne, A. W. (2022)
Q fever and early pregnancy failure: a Scottish case control study. Reproduction and Fertility, 3(1), https://doi.org/10.1530/raf-21-0072

Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion

Journal Article
Livingstone, M., Ranjan Wattegedera, S., Palarea-Albaladejo, J., Aitchison, K., Corbett, C., Sait, M., …Longbottom, D. (2021)
Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion. Vaccines, 9(8), Article 898. https://doi.org/10.3390/vaccines9080898
Chlamydia abortus, the aetiological agent of enzootic abortion of ewes, is a major cause of reproductive loss in small ruminants worldwide, accounting for significant economic...

Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells

Journal Article
Brown, M., Rae, M., & Wheelhouse, N. (2021)
Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells. Reproduction and Fertility, 2(1), 9-11. https://doi.org/10.1530/RAF-20-0069
Chlamydia trachomatis is the most commonly diagnosed sexually transmitted infection in the UK, with over 200,000 positive diagnoses annually. The infection is thought to cause...

Molecular detection of Coxiella burnetii infection in small mammals from Moshi Rural and Urban Districts, northern Tanzania

Journal Article
Theonest, N. O., Carter, R. W., Kasagama, E., Keyyu, J. D., Shirima, G. M., Tarimo, R., …Halliday, J. E. (2021)
Molecular detection of Coxiella burnetii infection in small mammals from Moshi Rural and Urban Districts, northern Tanzania. Veterinary Medicine and Science, 7(3), 960-967. https://doi.org/10.1002/vms3.401
Coxiella burnetii is an obligate intracellular bacterium that causes Q fever, a zoonotic disease of public health importance. In northern Tanzania, Q fever is a known cause of...

Association of past Chlamydia trachomatis infection with miscarriage: Chlamydia trachomatis infection and miscarriage

Journal Article
Horne, A. W., Wheelhouse, N., Horner, P. J., & Duncan, W. C. (2020)
Association of past Chlamydia trachomatis infection with miscarriage: Chlamydia trachomatis infection and miscarriage. JAMA Network Open, 3(10), https://doi.org/10.1001/jamanetworkopen.2020.18799

Defining immune correlates during latent and active chlamydial infection in sheep

Journal Article
Ranjan Wattegedera, S., Livingstone, M., Maley, S., Rocchi, M., Lee, S., Pang, Y., …Entrican, G. (2020)
Defining immune correlates during latent and active chlamydial infection in sheep. Veterinary Research, 51, https://doi.org/10.1186/s13567-020-00798-6
Ovine enzootic abortion (OEA) caused by the obligate intracellular bacterial pathogen Chlamydia abortus (C. abortus), is an endemic disease in most sheep-rearing countries wor...

Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning

Journal Article
Longbottom, D., Livingstone, M., Aitchison, K. D., Imrie, L., Manson, E., Wheelhouse, N., & Inglis, N. F. (2019)
Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning. PLOS ONE, 14(10), https://doi.org/10.1371/journal.pone.0224070
Data are presented on the identification and partial characterisation of proteins comprising the chlamydial outer membrane complex (COMC) fraction of Chlamydia abortus (C. abo...

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study

Journal Article
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (2019)
Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), https://doi.org/10.1186/s12889-019-7313-0
Background Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital...

Pre-Napier Funded Projects

  • BBSRC/ Zoetis IPA Chlamydia-like organisms as a novel cause of bovine reproductive failure (£1.2 M)
  • Chief Scientist Office: Mitochondrial DNA deletions in Barrett's oesophagus (£25k)
  • Melville Trust: Mitochondrial DNA mutations as a sentinel marker of hepatocarcinogenesis (£50k)

Current Post Grad projects

Previous Post Grad projects