Nick Wheelhouse

Nick Wheelhouse

Dr Nick Wheelhouse BSc (Hons) PhD

Lecturer

Biography

I am currently working as a Lecturer in Microbiology within the School of Applied Sciences at Edinburgh Napier University.

I started my academic career started as Postdoctoral Research Fellow in the Department of Pathology at Edinburgh University where I worked on liver cancer and transplantation failure. It was here that I developed a keen interest into disease pathogenesis. I then moved to the Moredun Research Institute where I worked as a Senior Postdoctoral Scientist focusing my research into the effects of bacterial infections which cause reproductive complications in both humans and livestock.

I am a member of Edinburgh Infectious Diseases, the hub for infectious disease research in Edinburgh, a Council member for the Society for Reproduction and Fertility, a member of the Microbiology Society, a Fellow of the Higher Education Academy. I also act as an Associate Editor on Frontiers in Veterinary Science and Heliyon.

My main areas of research are the diagnosis, immunopathogenesis and epidemiology of reproductive infections. I am particularly interested in chlamydial infections of humans and animals, and more recently neglected causes of non-malarial fevers in sub-Saharan Africa including Q-fever and Brucellosis.

My work involves collaboration with multiple partner organisations including The Centre for Reproductive Health, at the University of Edinburgh, NHS Lothian and the Institute of Biodiversity Animal Health and Comparative Medicine at the University of Glasgow in the UK. Internationally I have developed strong links with Kwame Nkrumah University of Science and Technology in Ghana and the University of Campinas in Brazil.

Themes

Esteem

Advisory panels and expert committees or witness

  • Royal Society of Biology Animal Science Group
  • Council member- Society for Reproduction and Fertility
  • Expert of Science and Technology Evaluation- National Center of Science and Technology Evaluation, Kazakhstan
  • International External advisor for the Instituto Nacional de Tecnologia Agropecuaria (INTA) in Argentina (2015-)

 

Conference Activity

  • Session Chair (Fertility 2020)
  • Judging panel 'Postgraduate presentation' and 'Postdoctoral presentation' sessions Fertility 2020
  • Workshop organiser: KNUST, Kumasi, Ghana
  • Judging panel 'Best Poster' and 'ECR presentation' Fertility 2019, Birmingham
  • Conference Presentation: Fertility 2018, Liverpool
  • Conference Presentation: European Society for Coxiellosis, Chlamydioses, Anaplasmoses and Rickettsioses, Marseille,
  • Conference presentation: European Society for Chlamydia Research, Cambridge
  • Conference Presentation: European Meeting for Animal Chlamydioses, Paris
  • Conference Presentation: SRF annual meeting, Cambridge
  • Conference Presentation: Edinburgh Infectious Diseases Symposium, 2015
  • Conference Presentation: European Meeting for Animal Chlamydioses, Jena
  • Conference Presentation: European Society for Chlamydia Research, Amsterdam
  • Conference Presentation: FEMAC meeting, Murcia, 2009
  • Conference Presentation: European Society for Chlamydia Research, Aarhus, Denmark
  • Conference Presentation: COST855 meeting Pulawy, Poland
  • Conference Presentation: British Society for Immunology, Glasgow
  • Conference Presentation: COST855 meeting, Edinburgh
  • Conference Presentation: British Society of Animal Science, Scarborough
  • Conference Presentation: British Society for Nutrition, Glasgow

 

Editorial Activity

  • Frontiers in Veterinary Science- Associate Editor
  • Editorial Board Member 'Frontiers in Microbiology'
  • Associate Editor 'Heliyon' Elsevier

 

External Examining/Validations

  • The Royal Veterinary College- External Examiner

 

Grant Funding Panel Member

  • SRF- Grant awarding committee

 

Grant Reviewer

  • BBSRC Grant Reviewer
  • Research Foundation- Flanders (FWO) Grant Reviewer
  • The German Israeli Foundation for Scientific Research and Development- Grant Review
  • MRC Grant Reviewer
  • National Science Foundation (US)

 

Invited Speaker

  • Invited Speaker: SRF Early Career Research Workshop, Edinburgh
  • Acceptability of Extragenital Chlamydia testing in young women- NHS Research Scotland Annual Conference
  • Invited Speaker: Kumasi Centre for Collaborative Research, Kumasi, Ghana
  • Invited Speaker: Kwame Nkrumah University of Science and Technology, Kumasi, Ghaa
  • 'Q-fever' Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow
  • Invited talk: School of Life Sciences, Edinburgh Napier University
  • Global Research Alliance on climate change meeting Reading, June 2015. ‘Investigations into novel pathogens associated with bovine reproductive failure’.
  • FACCE JPI MACSUR LiveM meeting Potsdam, June 2016 'Animal Health and Greenhouse Gas Emissions Network: Achievements and Future'
  • Sheep Veterinary Society meeting, Jersey 2010 ‘Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion’

 

Media Activity

  • Q-fever podcast- Veterinary times
  • The Sheep Farmer March/ April 2012 ‘Controlling chlamydial abortion’
  • The Sheep Farmer July/Aug 2010 ‘Chlamydial abortion’
  • The Crofter Issue 88 Aug 2010 ‘Controlling chlamydial abortion in sheep’
  • ‘Chlamydial infection of sheep an infectious cause of prenatal lamb death’ http://www.knowledgescotland.org/briefings.php?id=209

 

Membership of Professional Body

  • Fellow of the Higher Education Academy

 

Public Engagement Activity

  • National Sheep Association (NSA) Scotsheep 2010
  • Royal Highland Show 2010
  • Royal Highland Show 2013
  • Royal Highland Show 2011
  • Moredun Animal Health Roadshow (Peebles) 2011
  • NSA National Event 2010
  • NSA Scotsheep 2011

 

Reviewing

  • Epidemiology and infection
  • Journal of Zoo and Wildlife Medicine
  • Frontiers in Microbiology
  • Veterinary Pathology
  • Transboundary and Emerging Diseases
  • BMC Veterinary Research
  • Emerging Infectious Diseases
  • Microbes & infection
  • PeerJ
  • Pathogens & disease
  • Veterinary Immunology & Immunopathology
  • Veterinary Journal
  • Veterinary Record
  • Veterinary Microbiology
  • Chemistry & Biology

 

Visiting Positions

  • Guest Lecturer- University of Liverpool Veterinary School

 

Date


65 results

Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning

Journal Article
Longbottom, D., Livingstone, M., Aitchison, K. D., Imrie, L., Manson, E., Wheelhouse, N., & Inglis, N. F. (2019)
Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning. PLOS ONE, 14(10), https://doi.org/10.1371/journal.pone.0224070
Data are presented on the identification and partial characterisation of proteins comprising the chlamydial outer membrane complex (COMC) fraction of Chlamydia abortus (C. abo...

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study

Journal Article
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (2019)
Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), https://doi.org/10.1186/s12889-019-7313-0
Background Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital...

Listeria monocytogenes isolates from ready to eat plant produce are diverse and have virulence potential.

Journal Article
Smith, A., Hearn, J., Taylor, C., Wheelhouse, N., Kaczmarek, M., Moorhouse, E., & Singleton, I. (2019)
Listeria monocytogenes isolates from ready to eat plant produce are diverse and have virulence potential. International Journal of Food Microbiology, 299, 23-32. https://doi.org/10.1016/j.ijfoodmicro.2019.03.013
Listeria monocytogenes is sporadically detected on a range of ready to eat fresh produce lines, such as spinach and rocket, and is a threat to public health. However, little i...

Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa.

Journal Article
Salifu, S. P., Bukari, A. A., Frangoulidis, D., & Wheelhouse, N. (2019)
Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa. Acta tropica, 193, 99-105. https://doi.org/10.1016/j.actatropica.2019.02.032
Q fever is a bacterial worldwide zoonosis (except New Zealand) caused by the Gram-negative obligate intracellular bacterium Coxiella burnetii (C. burnetii). The bacterium has ...

Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction

Journal Article
Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., …Entrican, G. (2019)
Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025
Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is ...

Ferlavirus-related deaths in a collection of viperid snakes

Journal Article
Flach, E. J., Dagleish, M. P., Feltrer, Y., Gill, I. S., Marschang, R. E., Masters, N., …Wheelhouse, N. M. (2018)
Ferlavirus-related deaths in a collection of viperid snakes. Journal of Zoo and Wildlife Medicine, 49(4), 983-995. https://doi.org/10.1638/2017-0223.1
Between June and October 2013 26 snakes of six viperid species kept in two adjoining rooms died (n = 16) or were euthanized on medical (1) or welfare grounds (9). Two were fro...

Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment

Journal Article
Ahmad, S. F., Brown, J. K., Campbell, L. L., Koscielniak, M., Oliver, C., Wheelhouse, N., …Horne, A. W. (2018)
Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment. EBioMedicine, https://doi.org/10.1016/j.ebiom.2018.02.020
Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo...

Control of Antimicrobial Resistance Requires an Ethical Approach

Journal Article
Parsonage, B., Hagglund, P. K., Keogh, L., Wheelhouse, N., Brown, R. E., & Dancer, S. J. (2017)
Control of Antimicrobial Resistance Requires an Ethical Approach. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.02124
Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the pro...

Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain

Journal Article
Velasova, M., Damaso, A., Prakashbabu, B. C., Gibbons, J., Wheelhouse, N., Longbottom, D., …Guitian, J. (2017)
Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain. Journal of Dairy Science, 100(11), 9215-9233. https://doi.org/10.3168/jds.2016-11863
To implement appropriate and effective disease control programs at national level, up-to-date and unbiased information on disease frequency is needed. The aim of this study w...

Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release

Journal Article
Giakoumelou, S., Wheelhouse, N., Brown, J., Wade, J., Simitsidellis, I., Gibson, D., …Horne, A. W. (2017)
Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release. Scientific Reports, 7(1), https://doi.org/10.1038/s41598-017-02223-z
Miscarriage affects ~20% of pregnancies and 30 maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but ...

Pre-Napier Funded Projects

  • BBSRC/ Zoetis IPA Chlamydia-like organisms as a novel cause of bovine reproductive failure (£1.2 M)
  • Chief Scientist Office: Mitochondrial DNA deletions in Barrett's oesophagus (£25k)
  • Melville Trust: Mitochondrial DNA mutations as a sentinel marker of hepatocarcinogenesis (£50k)

Current Post Grad projects

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