Research Output
Dietary nitrate supplementation alters the oral microbiome but does not improve the vascular responses to an acute nitrate dose
  Nitrate (NO3−) contained in food and beverages can transiently increase nitric oxide (NO) availability following a stepwise reduction to nitrite (NO2−) by commensal bacteria in the oral cavity. We tested the hypothesis that regular ingestion of dietary NO3− would influence the oral microbiome, the capacity to reduce NO3− to NO2− in saliva, and the vascular responses to an acute dose of NO3−. The abundance of bacterial species on the tongue, the availability of NO markers, and vascular function were assessed in 11 healthy males before and after 7 days of supplementation with NO3−-rich beetroot juice and a NO3−-depleted placebo. As expected, saliva and plasma NO2− and NO3− were significantly elevated after NO3− supplementation (all P

  • Type:

    Article

  • Date:

    30 April 2019

  • Publication Status:

    Published

  • Publisher

    Elsevier BV

  • DOI:

    10.1016/j.niox.2019.04.010

  • Cross Ref:

    10.1016/j.niox.2019.04.010

  • ISSN:

    1089-8603

  • Funders:

    Historic Funder (pre-Worktribe)

Citation

Burleigh, M., Liddle, L., Muggeridge, D. J., Monaghan, C., Sculthorpe, N., Butcher, J., …Easton, C. (2019). Dietary nitrate supplementation alters the oral microbiome but does not improve the vascular responses to an acute nitrate dose. Nitric Oxide: Biology and Chemistry, 89, 54-63. https://doi.org/10.1016/j.niox.2019.04.010

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