Research explorer tool

37 results

Models of osteoarthritis: relevance and new insights

Journal Article
Samvelyan, H., Hughes, D., Stevens, C., & Staines, K. A. (in press)
Models of osteoarthritis: relevance and new insights. Calcified Tissue International, https://doi.org/10.1007/s00223-020-00670-x
Osteoarthritis (OA) is a progressive and disabling musculoskeletal disease affecting millions of people and resulting in major healthcare costs worldwide. It is the most commo...

Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection

Journal Article
Casanova, V., Sousa, F. H., Shakamuri, P., Svoboda, P., Buch, C., D'Acremont, M., …Barlow, P. G. (2020)
Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection. Frontiers in Immunology, 11, https://doi.org/10.3389/fimmu.2020.00085
Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections. While normally mild and self-limiting in healthy adults, HRV infections are associate...

Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo

Journal Article
Mathur, S., Turnbull, A., Akaev, I., Stevens, C., Agrawal, N., Chopra, M., & Mincher, D. (in press)
Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo. International Journal of Peptide Research and Therapeutics, https://doi.org/10.1007/s10989-019-09994-1
The lysosomal endoprotease legumain (asparaginyl endoprotease) has been proposed as a putative biomarker in prostate tumours, in which the enzyme is markedly overexpressed. Ov...

Azathioprine Has a Deleterious Effect on the Bone Health of Mice with DSS-Induced Inflammatory Bowel Disease

Journal Article
Morgan, S., Hooper, K. M., Milne, E. M., Farquharson, C., Stevens, C., & Staines, K. A. (2019)
Azathioprine Has a Deleterious Effect on the Bone Health of Mice with DSS-Induced Inflammatory Bowel Disease. International Journal of Molecular Sciences, 20(23), https://doi.org/10.3390/ijms20236085
Patients with inflammatory bowel disease (IBD) often present poor bone health and are 40% more at risk of bone fracture. Studies have implicated autophagy in IBD pathology and...

Regulation of the expression of DAPK1 by SUMO pathway.

Journal Article
Wang, Q., Zhang, X., Chen, L., Weng, S., Xia, Y., Ye, Y., …Lin, Y. (2019)
Regulation of the expression of DAPK1 by SUMO pathway. Biomolecules, 9(4), 151. https://doi.org/10.3390/biom9040151
Death Associated Protein Kinase 1 (DAPK1) is an important signaling kinase mediating the biological e ect of multiple natural biomolecules such as IFN-, TNF- , curcumin, etc. ...

The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK

Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., …Stevens, C. (2019)
The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039
Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this s...

The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy

Journal Article
Biskou, O., Casanova, V., Hooper, K., Kemp, S., Wright, G. P., Satsangi, J., …Stevens, C. (2019)
The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE, 14(1), https://doi.org/10.1371/journal.pone.0209665
The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes includi...

Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease

Journal Article
Hooper, K. M., Barlow, P. G., Henderson, P., & Stevens, C. (2019)
Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 25(4), 661-671. https://doi.org/10.1093/ibd/izy380
Inflammatory Bowel Disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis, is characterised by chronic inflammation of the gastrointestinal tract. Aetiology...

Antiviral therapeutic approaches for human rhinovirus infections

Journal Article
Casanova, V., Sousa, F. H., Stevens, C., & Barlow, P. G. (2018)
Antiviral therapeutic approaches for human rhinovirus infections. Future Virology, https://doi.org/10.2217/fvl-2018-0016
Human rhinoviruses (RV) are the primary etiological agent of the common cold. This infection can be mild and self-limiting in immunocompetent hosts, but can be associated wit...

Cathelicidins display conserved direct antiviral activity towards rhinovirus.

Journal Article
Sousa, F. H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., …Barlow, P. G. (2017)
Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides, 95, 76-83. https://doi.org/10.1016/j.peptides.2017.07.013
Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised ind...
6 results

Host Defence Peptides as novel modulators of autophagy in Inflammatory Bowel Disease

2019 - 2022
Increasing numbers of patients are diagnosed with inflammatory bowel disease (IBD) each year, both in the United Kingdom and worldwide. Most drugs in current use for the treatment of IBD target the im...
Funder: The Daphne Jackson Trust | Value: £83,167

Cathelicidins as Novel Therapeutic Antivirals for Dengue Infection

2019 - 2022
A significant challenge faced by modern society is the lack of therapeutics for a large number of infections, particularly those that are endemic or widely spread in developing countries. Dengue is on...
Funder: Medical Research Council | Value: £269,873

Development of a novel 3D culture system to understand bone:cartilage crosstalk in osteoarthritis

2018 - 2022
Osteoarthritis affects more than 9 million people in the UK and is the leading cause of disability. In osteoarthritis, joint tissues (cartilage and bone) undergo structural damage which ultimately pro...
Funder: Medical Research Scotland | Value: £128,430

IDEA

2017 - 2018
An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for treatment of paediatric IBD
Funder: Crohn's in Childhood Research Association | Value: £5,274

Cathelicidins as novel therapeutic antiviral agents in Rhinovirus infection

2015 - 2017
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a...
Funder: Chief Scientists Office | Value: £163,152

PhD studentship for CIRCA

2014 - 2017
Recent genetic discoveries, principally identification of NOD2 and ATG16L1 as susceptibility loci, strongly implicate a dysregulated host response to enteric bacteria and the autophagy pathway in the ...
Funder: Crohn's in Childhood Research Association | Value: £68,577
12 results

The effects of inflammatory bowel disease drugs on bone metabolism

2018 - 2019
Stephanie Morgan | Director of Studies: Dr Katherine Staines | Second Supervisor: Dr Craig Stevens

Role of hypoxia in inflammatory bowel disease

2018 - date
Alice Arnold | Director of Studies: Dr Craig Stevens | Second Supervisor: Dr Jenny Fraser

Modulation of autophagy by thiopurines

2018 - date
Connan Masson | Director of Studies: Dr Craig Stevens | Second Supervisor: Prof Peter Barlow

Development of a novel three-dimensional (3D) culture system to understand bone: cartilage crosstalk in osteoarthritis

2018 - date
David Hughes | Director of Studies: Dr Craig Stevens | Second Supervisor: Dr Craig Stevens

Design and development of novel targeted anticancer drugs.

2018 - date
Ewoma Akpughe | Director of Studies: Dr David Mincher | Second Supervisor: Agnes Turnbull

Player load monitoring and performance in elite Scottish Rugby Union

2017 - date
Cameron Paul | Director of Studies: Dr Debbie Palmer | Second Supervisor: Dr Tom Campbell

The effects of Inflammatory Bowel Disease drugs on the autophagy pathway

2014 - 2019
Inflammatory Bowel Disease (IBD), which includes Crohn’s disease (CD) and Ulcerative Colitis, is characterised by chronic inflam...
Kirsty Hooper | Director of Studies: Dr Craig Stevens | Second Supervisor: Prof Peter Barlow

The role of the cytoskeleton in autophagy and Crohn's disease

2014 - 2020
Olga Biskou | Director of Studies: Dr Craig Stevens | Second Supervisor: Prof Peter Barlow

Regulation of autophagy in cathelicidin/vitamin D signalling pathway

2014 - 2016
Sophie Shepherd | Director of Studies: Dr Craig Stevens | Second Supervisor: Prof Peter Barlow

The role of the human cathelicidin LL-37 in rhinovirus infection

2014 - 2019
The PhD project which I am undertaking is focused on understanding the role of cathelicidins during respiratory viral infections. Cathel...
Dr Filipa Henderson Sousa | Director of Studies: Prof Peter Barlow | Second Supervisor: Dr Craig Stevens

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