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31 results

Trust, inflammatory biomarkers and adversity: a novel investigation and clinical implications

Journal Article
Chouliara, Z., & Barlow, P. G. (2023)
Trust, inflammatory biomarkers and adversity: a novel investigation and clinical implications. British Journal of Guidance and Counselling, 51(4), 528-545. https://doi.org/10.1080/03069885.2022.2039899
Survivors of adversity and trauma experience high levels of distress, interpersonal challenges and poor physical health. We investigated the role of trust in trauma-related ps...

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Journal Article
Klionsky, D. J., Kamal Abdel-Aziz, A., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., …et al., . (2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1), 1-382. https://doi.org/10.1080/15548627.2020.1797280
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have e...

Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection

Journal Article
Casanova, V., Sousa, F. H., Shakamuri, P., Svoboda, P., Buch, C., D'Acremont, M., …Barlow, P. G. (2020)
Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection. Frontiers in Immunology, 11, https://doi.org/10.3389/fimmu.2020.00085
Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections. While normally mild and self-limiting in healthy adults, HRV infections are associate...

The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK

Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., …Stevens, C. (2019)
The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039
Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this s...

The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy

Journal Article
Biskou, O., Casanova, V., Hooper, K., Kemp, S., Wright, G. P., Satsangi, J., …Stevens, C. (2019)
The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE, 14(1), https://doi.org/10.1371/journal.pone.0209665
The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes includi...

Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease

Journal Article
Hooper, K. M., Barlow, P. G., Henderson, P., & Stevens, C. (2019)
Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 25(4), 661-671. https://doi.org/10.1093/ibd/izy380
Inflammatory Bowel Disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis, is characterised by chronic inflammation of the gastrointestinal tract. Aetiology...

Antiviral therapeutic approaches for human rhinovirus infections

Journal Article
Casanova, V., Sousa, F. H., Stevens, C., & Barlow, P. G. (2018)
Antiviral therapeutic approaches for human rhinovirus infections. Future Virology, https://doi.org/10.2217/fvl-2018-0016
Human rhinoviruses (RV) are the primary etiological agent of the common cold. This infection can be mild and self-limiting in immunocompetent hosts, but can be associated wit...

Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration

Journal Article
Findlay, F., Pohl, J., Svoboda, P., Shakamuri, P., McLean, K., Inglis, N. F., …Barlow, P. G. (2017)
Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration. Journal of Immunology, 199(7), 2483-2490. https://doi.org/10.4049/jimmunol.1700706
Host defense peptides, also known as antimicrobial peptides, are key elements of innate host defense. One host defense peptide with well-characterized antimicrobial activity i...

Cathelicidins display conserved direct antiviral activity towards rhinovirus.

Journal Article
Sousa, F. H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., …Barlow, P. G. (2017)
Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides, 95, 76-83. https://doi.org/10.1016/j.peptides.2017.07.013
Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised ind...

Inflammatory Bowel Disease Drugs: A Focus on Autophagy

Journal Article
Hooper, K. M., Barlow, P. G., Stevens, C., & Henderson, P. (2017)
Inflammatory Bowel Disease Drugs: A Focus on Autophagy. Journal of Crohn's and Colitis, 11(1), 118-127. https://doi.org/10.1093/ecco-jcc/jjw127
Inflammatory bowel disease [IBD] is characterized by chronic inflammation of the gastrointestinal tract. Medications such as corticosteroids, thiopurines, immunomodulators and...
8 results

Entrepreneur-in-Residence 2020-2023 - Robert Goodfellow

2021 - 2023
The Royal Society Entrepreneur in Residence (EiR) scheme, part of the Science, Industry and Translation programme, aims to increase the knowledge and awareness in UK universities of cutting edge indus...
Funder: Royal Society

Host Defence Peptides as novel modulators of autophagy in Inflammatory Bowel Disease

2019 - 2022
Increasing numbers of patients are diagnosed with inflammatory bowel disease (IBD) each year, both in the United Kingdom and worldwide. Most drugs in current use for the treatment of IBD target the im...
Funder: The Daphne Jackson Trust | Value: £83,167

EEID travel award: Understanding transmission dynamics for bacterial zoonoses in humans, goats and camels among pastoral communities in Northern Kenya

2019 - 2019
EEID travel award: Understanding transmission dynamics for bacterial zoonoses in humans, goats and camels among pastoral communities in Northern Kenya
Funder: Biotechnology and Biological Sciences Research Council | Value: £1,960

Cathelicidins as Novel Therapeutic Antivirals for Dengue Infection

2019 - 2022
A significant challenge faced by modern society is the lack of therapeutics for a large number of infections, particularly those that are endemic or widely spread in developing countries. Dengue is on...
Funder: Medical Research Council | Value: £269,873

TRANSFORM - Education reform project – Improving Research capability in the Sri Lankan Higher Education sector.

2018 - 2019
TRANSFORM - Education reform project – Improving Research capability in the Sri Lankan Higher Education sector.
Funder: British Council | Value: £75,000

Electrolysed Water for Post-Harvest Washing (JadooJal)

2017 - 2019
assist the development of a novel electrolysed water based application to reduce spoilage and microbial contamination of a variety of fresh produce types of importance to Indian commerce.
Funder: Innovate UK | Value: £231,163

Cathelicidins as novel therapeutic antiviral agents in Rhinovirus infection

2015 - 2017
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a...
Funder: Chief Scientists Office | Value: £163,152

The Antiviral activities of the cationic host defence peptide LL-37 against Rhinovirus

2013 - 2014
A pump-priming proposal designed to investigate the potential for LL-37, a human cationic host defence peptide, to inhibit Rhinovirus infection and/or target cells infected with Rhinovirus for inducti...
Funder: Tenovus Scotland | Value: £10,000
15 results

Nanocellulose-Host Defence Peptide (N-HDP) Conjugates as a Novel Therapeutic Antiviral Technology

2022 - date
Connan Masson | Director of Studies: Prof Peter Barlow | Second Supervisor: Dr Mark Dorris

Analysis of circumstances leading to injuries in elite football players

2019 - date
Dr. Francesco Aiello | Director of Studies: Dr Susan Brown | Second Supervisor: Dr Alan McCall

Characterisation of autophagy modulation by thiopurines in inflammatory bowel disease

2018 - 2021
Connan Masson | Director of Studies: Dr Craig Stevens | Second Supervisor: Prof Peter Barlow

The interaction of regulatory T-cells and osteoclasts in health and ageing

2018 - date
Raquel Lopera-Burgueno | Director of Studies: Dr Graham Wright | Second Supervisor: Prof Peter Barlow

Development of a novel 3D culture system to understand bone: cartilage crosstalk in osteoarthritis

2018 - date
David Hughes | Director of Studies: Dr Craig Stevens | Second Supervisor: Dr Craig Stevens

Generating ag-specific human regulatory T-cells by TCR gene transfer for the treatment of rheumatoid arthritis

2017 - 2018
Victoria Riddell | Director of Studies: Dr Graham Wright | Second Supervisor: Prof Peter Barlow

Cationic Host Defence Peptides as novel therapeutics for Chlamydia infection

2016 - 2018
Beatriz Cozar Fernandez | Director of Studies: Prof Peter Barlow | Second Supervisor: Dr Nick Wheelhouse

The role of exercise and age on vitamin D metabolism

2015 - 2019
My main area of research interest is the role of exercise and ageing on vitamin D metabolism. Scotland is identified as a vitamin D deficient nation...
Dr Hannah Margaret Lithgow | Director of Studies: Dr Mel Leggate | Second Supervisor: Prof G Florida-James

Regulation of autophagy in cathelicidin/vitamin D signalling pathway

2014 - 2016
Sophie Shepherd | Director of Studies: Dr Craig Stevens | Second Supervisor: Prof Peter Barlow

Investigation of new actinobacteria for the biodesulphurisation of diesel fuel

2014 - 2020
Selva Athi Narayanan | Director of Studies: Dr Fiona Stainsby | Second Supervisor: Prof Nick Christofi