Margarete Heck (1959–2023): Cell biologist, geneticist, and incandescent social spark
Journal Article
Cobbe, N., Di Cara, F., Spradling, A. C., & Vass, S. (2024)
Margarete Heck (1959–2023): Cell biologist, geneticist, and incandescent social spark. Journal of Cell Biology, 223(1), Article e202311145. https://doi.org/10.1083/jcb.202311145
A role for the metalloprotease invadolysin in insulin signaling and adipogenesis
Journal Article
Chang, C., Abhinav, K., Di Cara, F., Panagakou, I., Vass, S., & Heck, M. M. (2017)
A role for the metalloprotease invadolysin in insulin signaling and adipogenesis. Biological Chemistry, 398(3), 373-393. https://doi.org/10.1515/hsz-2016-0226
Invadolysin is a novel metalloprotease conserved amongst metazoans that is essential for life in Drosophila. We previously showed that invadolysin was essential for the cell c...
Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart
Journal Article
Wilson, K. S., Baily, J., Tucker, C. S., Matrone, G., Vass, S., Moran, C., …Denvir, M. A. (2015)
Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart. Molecular and Cellular Endocrinology, 414, 120-131. https://doi.org/10.1016/j.mce.2015.07.025
Background
Transient early-life perturbations in glucocorticoids (GC) are linked with cardiovascular disease risk in later life. Here the impact of early life manipulations o...
Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart
Journal Article
Wilson, K., Baily, J., Tucker, C., Vass, S., Moran, C., Chapman, K., …Denvir, M. (2015)
Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart. Heart, 101(Suppl 4), A107.3-A108. https://doi.org/10.1136/heartjnl-2015-308066.193
Introduction Foetal over-exposure to glucocorticoids (GC) has been associated with cardiovascular disorder in later life however the impact of transient early life alterations...
Invadolysin acts genetically via the SAGA complex to modulate chromosome structure
Journal Article
Janiszewski, M. M., Heck, M. M., Rao, S. G., Janiszewski, M. M., Duca, E., Nelson, B., …Heck, M. M. S. (2015)
Invadolysin acts genetically via the SAGA complex to modulate chromosome structure. Nucleic Acids Research, 43(7), 3546-3562. https://doi.org/10.1093/nar/gkv211
Identification of components essential to chromosome structure and behaviour remains a vibrant area of study. We have previously shown that invadolysin is essential in Drosoph...
Heart on a Plate: Histological and Functional Assessment of Isolated Adult Zebrafish Hearts Maintained in Culture
Journal Article
Pieperhoff, S., Wilson, K. S., Baily, J., de Mora, K., Maqsood, S., Vass, S., …Denvir, M. A. (2014)
Heart on a Plate: Histological and Functional Assessment of Isolated Adult Zebrafish Hearts Maintained in Culture. PLOS ONE, 9(5), https://doi.org/10.1371/journal.pone.0096771
The zebrafish is increasingly used for cardiovascular genetic and functional studies. We present a novel protocol to maintain and monitor whole isolated beating adult zebrafis...
Perturbation of invadolysin disrupts cell migration in zebrafish (Danio rerio)
Journal Article
Vass, S., & Heck, M. M. S. (2013)
Perturbation of invadolysin disrupts cell migration in zebrafish (Danio rerio). Experimental Cell Research, 319(8), 1198-1212. https://doi.org/10.1016/j.yexcr.2013.02.005
Invadolysin is an essential, conserved metalloprotease which links cell division with cell migration and is intriguingly associated with lipid droplets. In this work we examin...
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling
Journal Article
Bolukbasi, E., Vass, S., Cobbe, N., Nelson, B., Simossis, V., Dunbar, D. R., & Heck, M. M. S. (2012)
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. Open Biology, 2(1), 110031-110031. https://doi.org/10.1098/rsob.110031
Multi-cellular organisms need to successfully link cell growth and metabolism to environmental cues during development. Insulin receptor–target of rapamycin (InR–TOR) signalli...
The conserved metalloprotease invadolysin localizes to the surface of lipid droplets
Journal Article
Cobbe, N., Marshall, K. M., Rao, S. G., Chang, C., Di Cara, F., Duca, E., …Heck, M. M. (2009)
The conserved metalloprotease invadolysin localizes to the surface of lipid droplets. Journal of Cell Science, 122(18), 3414-3423. https://doi.org/10.1242/jcs.044610
Invadolysin is a metalloprotease conserved in many different organisms, previously shown to be essential in Drosophila with roles in cell division and cell migration. The gene...
Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells
Journal Article
Crevel, G., Hashimoto, R., Vass, S., Sherkow, J., Yamaguchi, M., Heck, M. M., & Cotterill, S. (2007)
Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells. PLOS ONE, 2(9), https://doi.org/10.1371/journal.pone.0000833
Background
The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC compon...