Amy Poole

Amy Poole

Dr Amy Poole BSc (Hons), PhD

Lecturer in Biomedical Science

Biography

After completing her undergraduate degree in Applied Biology (specialising in Microbiology), Amy worked for an Agricultural company involved in efficacy and toxicity testing of pesticides. She then joined Professor Mark Darlison in the Signal Transduction laboratory at Nottingham Trent University where she undertook a PhD investigating the molecular signalling cascades involved in learning and memory in the Zebra finch.

Following completion of her PhD in 2010, Amy began work at Edinburgh Napier University as an online lecturer, which quickly evolved into a full-time teaching position. Amy is now the route leader for 3rd and 4th year undergraduate Biomedical Science and her current teaching is focussed in her area of expertise (molecular biology), which she teaches at both undergraduate, and postgraduate levels.

Amy maintained a research collaboration with the late Professor Darlison in the field of neurobiology and has since formed strong collaborative links at Edinburgh Napier University with Dr Jenny Fraser and Professor Mick Rae. Amy is the principle investigator of several projects including the molecular mechanisms underlying penumbral evolution in stroke and neuroendocrine differentiation in castrate-resistant prostate cancer. She has a number of successful MRes and PhD completions. A more recent project, in collaboration with Professor Rae is focussed on steroid excess in prenatal programming.

Themes

Esteem

External Examining/Validations

  • External examiner for a PhD in Spain (the University of Leon)

 

Reviewing

  • Occasional reviewer for Cellular and Molecular Neurobiology

 

Date


10 results

Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer

Journal Article
Meehan, J., Gray, M., Martínez-Pérez, C., Kay, C., Pang, L. Y., Fraser, J. A., …Turnbull, A. K. (2020)
Precision Medicine and the Role of Biomarkers of Radiotherapy Response in Breast Cancer. Frontiers in Oncology, 10, https://doi.org/10.3389/fonc.2020.00628
Radiotherapy remains an important treatment modality in nearly two thirds of all cancers, including the primary curative or palliative treatment of breast cancer. Unfortunatel...

hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon reintroduction of androgen

Journal Article
Fraser, J. A., Sutton, J. E., Tazayoni, S., Bruce, I., & Poole, A. V. (2019)
hASH1 nuclear localization persists in neuroendocrine transdifferentiated prostate cancer cells, even upon reintroduction of androgen. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-55665-y
Neuroendocrine prostate cancer (NEPC) is thought to arise as prostate adenocarcinoma cells transdifferentiate into neuroendocrine (NE) cells to escape potent anti-androgen the...

Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia

Journal Article
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V., & Fraser, J. A. (2017)
Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLOS ONE, 12(10), https://doi.org/10.1371/journal.pone.0185664
Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxyg...

Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia

Presentation / Conference
Fraser, J., Baudel, M., Rae, M., Darlison, M., & Poole, A. (2017, April)
Preferential activation of HIF-2 adaptive mechanisms in neuronal-like cells in response to hypoxia. Poster presented at British Neuroscience Association - festival of neuroscience 2017
Stroke is a leading cause of death and disability worldwide. Blockage, or occlusion, of cerebral arteries causes irreversible neuronal damage as disrupted blood flow starves n...

The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following

Conference Proceeding
Baudel, M., Rae, M., Fraser, J., & Poole, A. (2017)
The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following. In Brain and Neuroscience: BNA 2017 Festival of Neuroscience: Abstract Book
Stroke is one of the major causes of death and disability worldwide. The harm caused by the interruption of blood flow to the brain unfolds in the subsequent hours and days, s...

Chloride co-transporters as possible therapeutic targets for stroke

Journal Article
Martín-Aragón Baudel, M. A. S., Martín-Aragón Baudel, M. A. S., Poole, A. V., & Darlison, M. G. (2017)
Chloride co-transporters as possible therapeutic targets for stroke. Journal of Neurochemistry, 140(2), 195-209. https://doi.org/10.1111/jnc.13901
Stroke is one of the major causes of death and disability worldwide. The major type of stroke is an ischaemic one, which is caused by a blockage that interrupts blood flow to...

Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells

Conference Proceeding
Sutton, J., Hutchison, G., Fraser, J., & Poole, A. (2016)
Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells
Background: Neuroendocrine differentiation is commonplace in prostate tumors treated with androgen deprivation therapy and is associated with castrate-resistant disease progre...

Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer

Journal Article
Mathur, S., Mincher, D., Turnbull, A., Stevens, C., & Poole, A. (2016)
Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer. European Journal of Cancer, 61, S142. https://doi.org/10.1016/s0959-8049%2816%2961501-0
Background: In spite of major advances in the diagnosis and treatment of cancer, there remains a paucity of biomarkers for early detection. Legumain is a potential cancer biom...

GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus

Journal Article
Darlison, M. G., Dos-Anjos, S., Llorente, I. L., Llorente, I. L., Perez-Rodriguez, D., Martínez-Villayandre, B., …Fernández-López, A. (2013)
GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus. Brain Research, 1533, 141-151. https://doi.org/10.1016/j.brainres.2013.08.024
Assays on "ex vivo" sections of rat hippocampus and rat cerebral cortex, subjected to oxygen and glucose deprivation (OGD) and a three-hour reperfusion-like (RL) recovery, wer...

Differential effect of transient global ischaemia on the levels of GABA(A) receptor subunit mRNAs in young and older rats.

Journal Article
Montori, S., Dos Anjos, S., Poole, A. V., Regueiro-Purrinos, M. M., Llorente, I. L., Darlison, M. G., …Martínez-Villayandre, B. (2012)
Differential effect of transient global ischaemia on the levels of GABA(A) receptor subunit mRNAs in young and older rats. Neuropathology and Applied Neurobiology, 38, 710-722. https://doi.org/10.1111/j.1365-2990.2012.01254.x
Aims: This study has investigated how global brain ischaemia/reperfusion (I/R) modifies levels of mRNAs encoding GABA(A) receptor alpha1, beta2 and gamma2 subunits and glutami...

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