Janis MacCallum

Janis MacCallum

Dr Janis MacCallum BSc (Hons), Ph.D. SFHEA C.Sci Teach

Lecturer

Biography

Dr Janis MacCallum (she/her) SFHEA CSci Teach is a lecturer in the School of Applied Sciences. She is currently a Programme Leader for the Bio-molecular suite of programmes and Employability Lead within the School.

Janis graduated from Glasgow University with an honours degree in Immunology and went on to undertake her Ph.D. in Immunology at Strathclyde University in Glasgow, working on the use of biosensor devices for the detection of bacterial infections, in conjunction with Amersham International.

In 1991 she moved to Edinburgh to start the first of three post-doctoral positions based at the Western General Hospital in Edinburgh, working on growth factor expression, and tamoxifen levels in breast cancers with Mr Mike Dixon and Dr Bill Miller.

She started working as a lecturer at Edinburgh Napier University in 1999 and has latterly been a Programme Leader for the MSc Biomedical Sciences suite of programmes. She continues to carry out research on cancer, with interests in the toxicological effects of cancer pro-drugs, in collaboration with Dr David Mincher. She has also worked on projects around PCOS (Prof M.Rae) and the impact of Paraben use (Dr G.Russo) on tissues.

On the pedagogical side, Janis also leads the Skills Passport programme within the school, which has developed a tool to engage students with skills assessment and reflection on their personal progress. As an extension of this, Janis leads the Employability Task Force within the School, with responsibility for encouraging links to industry and working to build good practice around employability within the various areas of the School. This necessitates close engagement with programmes across the school and with employers across the sector.

Themes

Esteem

Fellowships and Awards

  • Winner for CSciTeach, CPD Science Council Awards 2019
  • RSB Chartered Science teacher (C Sci Teach)

 

Date


20 results

Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration

Journal Article
Barlow, P., Donaldson, K., MacCallum, J., Clouter, A., & Stone, V. (2005)
Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration. Toxicology Letters, 155(3), 397-401. https://doi.org/10.1016/j.toxlet.2004.11.006
Objective: To assess whether fine and ultrafine particles (nanoparticles) have the capacity to activate factors in serum that would induce macrophage migration. This is a mode...

Ticks and Lyme Disease.

Journal Article
Chalmers, C., MacCallum, J., Brown, J. & Anderson, R. (2003)
Ticks and Lyme Disease. Practice Nursing. 15. ISSN 0964-9271
Ticks are prevalent in parts of the UK during the summer months. Charlotte Chalmers, Janis MacCallum, Jane Brown and Ros Anderson discuss the associated diseases and recommend...

Concentration of tamoxifen and its major metabolites in hormone responsive and resistant breast tumours

Journal Article
MacCallum, J., Cummings, J., Dixon, J. M., & Miller, W. R. (2000)
Concentration of tamoxifen and its major metabolites in hormone responsive and resistant breast tumours. Nature, 82(10), 1629-1635. https://doi.org/10.1054/bjoc.2000.1120
Patients treated with tamoxifen (TAM) for primary breast cancer often manifest de novo or acquired resistance, possibly through changes in drug metabolism. Using solid-phase e...

TGFbeta in the developing organism

Book Chapter
MacCallum, J. (1999)
TGFbeta in the developing organism. In J. R. Bensen (Ed.), TGFbeta and Cancer. Austin, USA: Landes Bioscience Publications

Absence of mutations in sites of key functional importance of the RIα and RIIβ regulatory subunits of protein kinase A in human breast cancers

Journal Article
Phillips, H., MacCallum, J., Burns, D., Cho-Chung, Y., & Miller, W. (1998)
Absence of mutations in sites of key functional importance of the RIα and RIIβ regulatory subunits of protein kinase A in human breast cancers. Breast, 7(3), 139-142. https://doi.org/10.1016/s0960-9776%2898%2990024-8
There is evidence that the regulatory subunits (R) of cyclic AMP-dependent protein kinase A (PKA) are important in the biology of breast cancer and that mutations of both RIα ...

Solid-phase extraction and high performance liquid chromatography determination of tamoxifen and its major metabolites in breast tumour tissues

Journal Article
MacCallum, J., Cummings, J., Dixon, J., & Miller, W. (1997)
Solid-phase extraction and high performance liquid chromatography determination of tamoxifen and its major metabolites in breast tumour tissues. Journal of Chromatography B, 698(1-2), 269-275. https://doi.org/10.1016/S0378-4347%2897%2900286-7
A sensitive (200 ng/g) and selective reversed-phase high-performance liquid chromatography separation has been developed to determine the levels of tamoxifen, 4-hydroxytamoxif...

Changes in expression of transforming growth factor beta mRNA isoforms in patients undergoing tamoxifen therapy

Journal Article
MacCallum, J., Keen, J., Bartlett, J., Thompson, A., Dixon, J., & Miller, W. (1996)
Changes in expression of transforming growth factor beta mRNA isoforms in patients undergoing tamoxifen therapy. British Journal of Cancer, 74(3), 474-478. https://doi.org/10.1038/bjc.1996.385
Tumour was obtained from 37 patients with oestrogen receptor-positive breast cancer, before and during treatment with tamoxifen, and examined qualitatively and semi-qualitativ...

Solid-phase extraction and high-performance liquid chromatographic determination of tamoxifen and its major metabolites in plasma

Journal Article
MacCallum, J., Cummings, J., Dixon, J., & Miller, W. (1996)
Solid-phase extraction and high-performance liquid chromatographic determination of tamoxifen and its major metabolites in plasma. Journal of Chromatography B, 678(2), 317-323. https://doi.org/10.1016/0378-4347%2895%2900530-7
Tamoxifen (TAM) is a triphenylethylene anti-oestrogen, commonly used in the treatment of breast cancer. Patients receiving tamoxifen therapy may experience both de novo and ac...

Expression and distribution of TGFβ mRNA isoforms in a small group of human breast cancers examined by in situ hybridization

Journal Article
MacCallum, J., Poulsom, R., Hanby, A., & Miller, W. (1995)
Expression and distribution of TGFβ mRNA isoforms in a small group of human breast cancers examined by in situ hybridization. Breast, 4(4), 289-296. https://doi.org/10.1016/s0960-9776%2895%2980006-9
As transforming growth factor betas (TGFβs) are of potential importance in the natural history of breast cancer, it is desirable to develop assays which allow detection of the...

Expression of transforming growth factor beta mRNA isoforms in human breast cancer

Journal Article
MacCallum, J., Bartlett, J., Thompson, A., Keen, J., Dixon, J., & Miller, W. (1994)
Expression of transforming growth factor beta mRNA isoforms in human breast cancer. British Journal of Cancer, 69(6), 1006-1009. https://doi.org/10.1038/bjc.1994.197
Using an RNAse protection assay, expression of messenger RNA for isoforms of TGF-beta was determined in a series of breast cancers. Of 50 tumours, 45 (90%) expressed TGF-beta ...

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