Nick Wheelhouse
Nick Wheelhouse

Dr Nick Wheelhouse BSc (Hons) PhD

Associate Professor

Biography

Associate Professor in microbiology and Deputy lead of the Centre for Biomedicine and Global Health within the School of Applied Sciences at Edinburgh Napier University.

I started my academic career as a Postdoctoral Research Fellow in the Department of Pathology at Edinburgh University where I worked in the areas of liver cancer and transplantation failure. It was here that I developed a keen interest in understanding the underlying causes of disease pathogenesis. I then moved to the Moredun Research Institute where I worked first as a Postdoctoral scientist and then as as Senior Postdoctoral Scientist focusing my research into the effects and impacts of bacterial infections which cause reproductive complications in both humans and livestock.

I co-lead of the Global research alliance Animal Health and Greenhouse Gas Intensity Network and I am a Trustee of the British Society for Animal Science. I hold memberships of Edinburgh Infectious Diseases, the hub for infectious disease research in Edinburgh, the Society for Reproduction and Fertility, Microbiology Society, British Society of Animal Science and I am a Fellow of the Higher Education Academy.

I have a breadth of research interests however the main areas of my research are the diagnosis, immunopathogenesis and epidemiology of reproductive infections particularly zoonoses that can be spread from animals to humans. I am particularly interested in understanding the impact of these infections on human health and quantifying their effects on livestock farming.

My work involves collaboration with multiple partner organisations in the UK and overseas, including NHS Lothian, the Institute of Biodiversity Animal Health and Comparative Medicine at the University of Glasgow in the UK where I am an Affiliated Researcher and the Royal (Dick) School of Veterinary Studies at the University of Edinburgh, where I am an honorary Fellow. Internationally I have collaborations with Kwame Nkrumah University of Science and Technology in Ghana, The University of Nairobi, and International Livestock Research Institute in Kenya.

Themes

Esteem

Advisory panels and expert committees or witness

  • Committee member Food Standards Agency Joint Expert Group on Animal Feed and Feed Additives - AFFAJEG
  • Food Standards Agency Advisory Committee on Animal Feedingstuffs - ACAF
  • Network Lead- Animal Health & Greenhouse Gas Emissions Intensity Network
  • Council member- Society for Reproduction and Fertility
  • Royal Society of Biology Animal Science Group
  • International External advisor for the Instituto Nacional de Tecnologia Agropecuaria (INTA) in Argentina (2015-)
  • Expert of Science and Technology Evaluation- National Center of Science and Technology Evaluation, Kazakhstan

 

Conference Organising Activity

  • Conference Presentation: Fertility 2022
  • Conference Presentation- Joint meeting of ESCCAR/ESCR 2022
  • Judging panel SRF Posters and 'Postdoctoral presentation' session Fertility 2022
  • Judging panel 'Postgraduate presentation' Fertility 2021
  • Conference Presentation: Fertility 2021, Online
  • Royal Society Westminster Pairing
  • Judging panel 'Postgraduate presentation' and 'Postdoctoral presentation' sessions Fertility 2020
  • Session Chair (Fertility 2020)
  • Workshop organiser: KNUST, Kumasi, Ghana
  • Judging panel 'Best Poster' and 'ECR presentation' Fertility 2019, Birmingham
  • Conference Presentation: Fertility 2018, Liverpool
  • Conference Presentation: European Society for Coxiellosis, Chlamydioses, Anaplasmoses and Rickettsioses, Marseille,
  • Conference presentation: European Society for Chlamydia Research, Cambridge
  • Conference Presentation: European Meeting for Animal Chlamydioses, Paris
  • Conference Presentation: SRF annual meeting, Cambridge
  • Conference Presentation: Edinburgh Infectious Diseases Symposium, 2015
  • Conference Presentation: European Meeting for Animal Chlamydioses, Jena
  • Conference Presentation: European Society for Chlamydia Research, Amsterdam
  • Conference Presentation: FEMAC meeting, Murcia, 2009
  • Conference Presentation: European Society for Chlamydia Research, Aarhus, Denmark
  • Conference Presentation: COST855 meeting Pulawy, Poland
  • Conference Presentation: COST855 meeting, Edinburgh
  • Conference Presentation: British Society for Immunology, Glasgow
  • Conference Presentation: British Society for Nutrition, Glasgow
  • Conference Presentation: British Society of Animal Science, Scarborough

 

Editorial Activity

  • Associate Editor Veterinary Sciences
  • Reproduction & Fertility- Associate Editor
  • Frontiers in Veterinary Science- Associate Editor
  • Editorial Board Member 'Frontiers in Microbiology'
  • Associate Editor 'Heliyon' Elsevier

 

External Examining/Validations

  • The Royal Veterinary College- External Examiner

 

Grant Funding Panel Member

  • SRF- Grant awarding committee

 

Grant Reviewer

  • Assessor Innovate UK
  • The University of Veterinary Medicine Vienna 'Top Vet Science' call
  • Research Foundation- Flanders (FWO) Grant Reviewer
  • BBSRC Grant Reviewer
  • The German Israeli Foundation for Scientific Research and Development
  • MRC Grant Reviewer
  • National Science Foundation (US)

 

Invited Speaker

  • Invited Seminar Speaker- Mazingira Centre, ILRI, Nairobi
  • Plenary Speaker 'Vision 2022', Cote d'Ivoire
  • Animal Health Network update: GRA LRG meeting 2022
  • Invited Speaker: SRF Early Career Research Workshop, Edinburgh
  • Acceptability of Extragenital Chlamydia testing in young women- NHS Research Scotland Annual Conference
  • Invited Speaker: Kwame Nkrumah University of Science and Technology, Kumasi, Ghaa
  • Invited Speaker: Kumasi Centre for Collaborative Research, Kumasi, Ghana
  • 'Q-fever' Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow
  • Invited talk: School of Life Sciences, Edinburgh Napier University
  • FACCE JPI MACSUR LiveM meeting Potsdam, June 2016 'Animal Health and Greenhouse Gas Emissions Network: Achievements and Future'
  • Sheep Veterinary Society meeting, Jersey 2010 ‘Evidence of Chlamydophila abortus vaccine strain 1B as a possible cause of ovine enzootic abortion’
  • Global Research Alliance on climate change meeting Reading, June 2015. ‘Investigations into novel pathogens associated with bovine reproductive failure’.

 

Media Activity

  • The Impact of infectious disease on livestock health-Blog
  • https://whylivestockmatter.org/articles/improving-animal-health-key-sustainable-livestock-production-and-better-human-health
  • Online Policy Brief- Improving animal health: a key to sustainable livestock production and better human health
  • Q-fever podcast- Veterinary times
  • The Sheep Farmer July/Aug 2010 ‘Chlamydial abortion’
  • The Sheep Farmer March/ April 2012 ‘Controlling chlamydial abortion’
  • ‘Chlamydial infection of sheep an infectious cause of prenatal lamb death’ http://www.knowledgescotland.org/briefings.php?id=209
  • The Crofter Issue 88 Aug 2010 ‘Controlling chlamydial abortion in sheep’

 

Membership of Professional Body

  • Fellow of the Higher Education Academy

 

Public Engagement Activity

  • Moredun Animal Health Roadshow (Peebles) 2011
  • NSA National Event 2010
  • National Sheep Association (NSA) Scotsheep 2010
  • Royal Highland Show 2011
  • Royal Highland Show 2010
  • NSA Scotsheep 2011
  • Royal Highland Show 2013

 

Public/Community Engagement

  • Livestock Health Workshop- Nandi County Kenya

 

Research Degree External Examining

  • External PhD examination University of Southampton 'Studies on the plasmid-based genetic tools for C. muridarum: progress towards a replicating vector for transposon mutagenesis'
  • University College Dublin PhD examiner 'Bovine sperm sexing impacts sperm morphokinetics, gameto-maternal interaction and subsequent early embryonic development'

 

Reviewing

  • Proceedings of the Royal Society B
  • Epidemiology and infection
  • Journal of Zoo and Wildlife Medicine
  • Frontiers in Microbiology
  • Transboundary and Emerging Diseases
  • Veterinary Pathology
  • Emerging Infectious Diseases
  • Veterinary Record
  • PeerJ
  • BMC Veterinary Research
  • Veterinary Immunology & Immunopathology
  • Veterinary Microbiology
  • Veterinary Journal
  • Chemistry & Biology
  • Pathogens & disease
  • Microbes & infection

 

Visiting Positions

  • International Livestock Research Institute (Nairobi)
  • Honorary Fellow Royal (Dick) School of Veterinary Studies
  • Glasgow University IBACHM- Affiliate Researcher
  • Guest Lecturer- University of Liverpool Veterinary School

 

Date


80 results

Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion

Journal Article
Livingstone, M., Ranjan Wattegedera, S., Palarea-Albaladejo, J., Aitchison, K., Corbett, C., Sait, M., …Longbottom, D. (2021)
Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion. Vaccines, 9(8), Article 898. https://doi.org/10.3390/vaccines9080898
Chlamydia abortus, the aetiological agent of enzootic abortion of ewes, is a major cause of reproductive loss in small ruminants worldwide, accounting for significant economic...

Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells

Journal Article
Brown, M., Rae, M., & Wheelhouse, N. (2021)
Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells. Reproduction and Fertility, 2(1), 9-11. https://doi.org/10.1530/RAF-20-0069
Chlamydia trachomatis is the most commonly diagnosed sexually transmitted infection in the UK, with over 200,000 positive diagnoses annually. The infection is thought to cause...

Molecular detection of Coxiella burnetii infection in small mammals from Moshi Rural and Urban Districts, northern Tanzania

Journal Article
Theonest, N. O., Carter, R. W., Kasagama, E., Keyyu, J. D., Shirima, G. M., Tarimo, R., …Halliday, J. E. (2021)
Molecular detection of Coxiella burnetii infection in small mammals from Moshi Rural and Urban Districts, northern Tanzania. Veterinary Medicine and Science, 7(3), 960-967. https://doi.org/10.1002/vms3.401
Coxiella burnetii is an obligate intracellular bacterium that causes Q fever, a zoonotic disease of public health importance. In northern Tanzania, Q fever is a known cause of...

Association of past Chlamydia trachomatis infection with miscarriage: Chlamydia trachomatis infection and miscarriage

Journal Article
Horne, A. W., Wheelhouse, N., Horner, P. J., & Duncan, W. C. (2020)
Association of past Chlamydia trachomatis infection with miscarriage: Chlamydia trachomatis infection and miscarriage. JAMA Network Open, 3(10), https://doi.org/10.1001/jamanetworkopen.2020.18799

Defining immune correlates during latent and active chlamydial infection in sheep

Journal Article
Ranjan Wattegedera, S., Livingstone, M., Maley, S., Rocchi, M., Lee, S., Pang, Y., …Entrican, G. (2020)
Defining immune correlates during latent and active chlamydial infection in sheep. Veterinary Research, 51, https://doi.org/10.1186/s13567-020-00798-6
Ovine enzootic abortion (OEA) caused by the obligate intracellular bacterial pathogen Chlamydia abortus (C. abortus), is an endemic disease in most sheep-rearing countries wor...

Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning

Journal Article
Longbottom, D., Livingstone, M., Aitchison, K. D., Imrie, L., Manson, E., Wheelhouse, N., & Inglis, N. F. (2019)
Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning. PLOS ONE, 14(10), https://doi.org/10.1371/journal.pone.0224070
Data are presented on the identification and partial characterisation of proteins comprising the chlamydial outer membrane complex (COMC) fraction of Chlamydia abortus (C. abo...

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study

Journal Article
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (2019)
Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), https://doi.org/10.1186/s12889-019-7313-0
Background Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital...

Listeria monocytogenes isolates from ready to eat plant produce are diverse and have virulence potential.

Journal Article
Smith, A., Hearn, J., Taylor, C., Wheelhouse, N., Kaczmarek, M., Moorhouse, E., & Singleton, I. (2019)
Listeria monocytogenes isolates from ready to eat plant produce are diverse and have virulence potential. International Journal of Food Microbiology, 299, 23-32. https://doi.org/10.1016/j.ijfoodmicro.2019.03.013
Listeria monocytogenes is sporadically detected on a range of ready to eat fresh produce lines, such as spinach and rocket, and is a threat to public health. However, little i...

Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa.

Journal Article
Salifu, S. P., Bukari, A. A., Frangoulidis, D., & Wheelhouse, N. (2019)
Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa. Acta tropica, 193, 99-105. https://doi.org/10.1016/j.actatropica.2019.02.032
Q fever is a bacterial worldwide zoonosis (except New Zealand) caused by the Gram-negative obligate intracellular bacterium Coxiella burnetii (C. burnetii). The bacterium has ...

Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction

Journal Article
Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., …Entrican, G. (2019)
Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025
Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is ...

Pre-Napier Funded Projects

  • BBSRC/ Zoetis IPA Chlamydia-like organisms as a novel cause of bovine reproductive failure (£1.2 M)
  • Chief Scientist Office: Mitochondrial DNA deletions in Barrett's oesophagus (£25k)
  • Melville Trust: Mitochondrial DNA mutations as a sentinel marker of hepatocarcinogenesis (£50k)

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