A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics
Journal Article
Johnston, H. J., Hutchison, G. R., Christensen, F. M., Peters, S., Hankin, S., Aschberger, K., & Stone, V. (2010)
A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: The contribution of physico-chemical characteristics. Nanotoxicology, 4(2), 207-246. https://doi.org/10.3109/17435390903569639
This critical review of the available human health safety data, relating to carbon nanotubes (CNTs), was conducted in order to assess the risks associated with CNT exposure. D...
Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation.
Journal Article
Buttle, D. J., Pitsillides, A. A., Staines, K. A., Javaheri, B., Hohenstein, P., Fleming, R., …Farquharson, C. (2017)
Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation. Journal of Cellular Physiology, 232(11), 3006-3019. https://doi.org/10.1002/jcp.25999
The transmembrane glycoprotein E11/Podoplanin (Pdpn) has been implicated in the initial stages of osteocyte differentiation. However, its precise function and regulatory mecha...
Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form
Journal Article
Fraser, J. A., Saunders, R. D. C., & McLellan, L. I. (2002)
Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form. Journal of Biological Chemistry, 277(2), 1158-1165. https://doi.org/10.1074/jbc.m106683200
Glutamate-cysteine ligase (GCL) plays an important role in regulating glutathione homeostasis. In mammals, it comprises a catalytic (GCLC) and modifier (GCLM) subunit. The exi...
Revising Nightingale's legacy
Journal Article
Dancer, S. (2020)
Revising Nightingale's legacy. Journal of Hospital Infection, 105(2), 344-345. https://doi.org/10.1016/j.jhin.2020.03.016
The recent editorial from this Journal does well to highlight the benefits of hand hygiene once again [ 1 ]. It is entirely appropriate to support the need for clean hands, es...
Cartilage to bone transitions in health and disease
Journal Article
Staines, K. A., Pollard, A. S., McGonnell, I. M., Farquharson, C., & Pitsillides, A. A. (2013)
Cartilage to bone transitions in health and disease. Journal of Endocrinology, 219(1), R1-R12. https://doi.org/10.1530/joe-13-0276
Aberrant redeployment of the 'transient' events responsible for bone development and postnatal longitudinal growth has been reported in some diseases in what is otherwise inhe...
The Ex Vivo Organ Culture of Bone
Book Chapter
Staines, K. A., Brown, G., & Farquharson, C. (2019)
The Ex Vivo Organ Culture of Bone. In Bone Research Protocols (199-215). New york, USA: Humana Press. https://doi.org/10.1007/978-1-4939-8997-3_10
The ex vivo organ culture of bone provides many of the advantages of both the whole organism and isolated cell strategies and can deliver valuable insight into the network of ...
Steroid signalling in the ovarian surface epithelium
Journal Article
Rae, M. T., & Hillier, S. G. (2005)
Steroid signalling in the ovarian surface epithelium. Trends in Endocrinology and Metabolism, 16(7), 327-333. https://doi.org/10.1016/j.tem.2005.07.002
Human ovarian surface epithelium (HOSE) undergoes serial injury-repair with each ovulation, which is probably why most ovarian epithelial cancers arise there. Considering the ...
Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis.
Journal Article
Lin, Y., Stevens, C., & Hupp, T. (2007)
Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis. Journal of Biological Chemistry, 282(23), 16792-16802. https://doi.org/10.1074/jbc.M611559200
DAPK-1 is a stress-activated tumor suppressor protein that plays a role in both proapoptotic or antiapoptotic signal transduction pathways. To define mechanisms of DAPK-1 prot...
MAPK Activation Is Essential for Waddlia chondrophila Induced CXCL8 Expression in Human Epithelial Cells
Journal Article
Storrie, S., Longbottom, D., Barlow, P. G., & Wheelhouse, N. (2016)
MAPK Activation Is Essential for Waddlia chondrophila Induced CXCL8 Expression in Human Epithelial Cells. PLOS ONE, 11(3), https://doi.org/10.1371/journal.pone.0152193
Background
Waddlia chondrophila (W. chondrophila) is an emerging agent of respiratory and reproductive disease in humans and cattle. The organism is a member of the order Chla...
Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence
Journal Article
Taylor, C. M., Beresford, M., Epton, H. A. S., Sigee, D. C., Shama, G., Andrew, P. W., & Roberts, I. S. (2002)
Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence. Journal of Bacteriology, 184(3), 621-628. https://doi.org/10.1128/JB.184.3.621-628.2002
We describe here the identification and characterization of two Listeria monocytogenes (Tn917-LTV3) relA and hpt transposon insertion mutants that were impaired in growth afte...