Date


Download Available

66 results

Revising Nightingale's legacy

Journal Article
Dancer, S. (2020)
Revising Nightingale's legacy. Journal of Hospital Infection, 105(2), 344-345. https://doi.org/10.1016/j.jhin.2020.03.016
The recent editorial from this Journal does well to highlight the benefits of hand hygiene once again [ 1 ]. It is entirely appropriate to support the need for clean hands, es...

Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis.

Journal Article
Lin, Y., Stevens, C., & Hupp, T. (2007)
Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis. Journal of Biological Chemistry, 282(23), 16792-16802. https://doi.org/10.1074/jbc.M611559200
DAPK-1 is a stress-activated tumor suppressor protein that plays a role in both proapoptotic or antiapoptotic signal transduction pathways. To define mechanisms of DAPK-1 prot...

Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study

Journal Article
Robertson, F. P., Goswami, R., Wright, G. P., Imber, C., Sharma, D., Malago, M., …Davidson, B. R. (2017)
Remote ischaemic preconditioning in orthotopic liver transplantation (RIPCOLT trial): a pilot randomized controlled feasibility study. HPB, 19(9), 757-767. https://doi.org/10.1016/j.hpb.2017.05.005
Background Ischaemia Reperfusion (IR) injury is a major cause of morbidity, mortality and graft loss following Orthotopic Liver Transplantation (OLT). Utilising marginal graft...

Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence

Journal Article
Taylor, C. M., Beresford, M., Epton, H. A. S., Sigee, D. C., Shama, G., Andrew, P. W., & Roberts, I. S. (2002)
Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence. Journal of Bacteriology, 184(3), 621-628. https://doi.org/10.1128/JB.184.3.621-628.2002
We describe here the identification and characterization of two Listeria monocytogenes (Tn917-LTV3) relA and hpt transposon insertion mutants that were impaired in growth afte...

Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men

Journal Article
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., …Florida-James, G. D. (2018)
Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017
Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, p...

Recruitment to the “Breast—Activity and Healthy Eating After Diagnosis” (B-AHEAD) Randomized Controlled Trial

Journal Article
Pegington, M., Adams, J. E., Bundred, N. J., Harvie, M. N., Campbell, A., Howell, A., …Harvey, M. (2018)
Recruitment to the “Breast—Activity and Healthy Eating After Diagnosis” (B-AHEAD) Randomized Controlled Trial. Integrative Cancer Therapies, 17(1), 131-137. https://doi.org/10.1177/1534735416687850
Excess weight at breast cancer diagnosis and weight gain during treatment are linked to increased breast cancer specific and all-cause mortality. The Breast—Activity and Healt...

Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo

Journal Article
Mathur, S., Turnbull, A., Akaev, I., Stevens, C., Agrawal, N., Chopra, M., & Mincher, D. (2020)
Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo. International Journal of Peptide Research and Therapeutics, 26, 1965-1980. https://doi.org/10.1007/s10989-019-09994-1
The lysosomal endoprotease legumain (asparaginyl endoprotease) has been proposed as a putative biomarker in prostate tumours, in which the enzyme is markedly overexpressed. Ov...

A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis

Journal Article
Stevens, C., Lin, Y., Sanchez, M., Amin, E., Copson, E., White, H., …Hupp, T. (2007)
A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis. Journal of Biological Chemistry, 282(18), 13791-13803. https://doi.org/10.1074/jbc.m605649200
p53 is activated genetically by a set of kinases that are components of the calcium calmodulin kinase superfamily, including CHK2, AMP kinase, and DAPK-1. In dissecting the me...

Control of Antimicrobial Resistance Requires an Ethical Approach

Journal Article
Parsonage, B., Hagglund, P. K., Keogh, L., Wheelhouse, N., Brown, R. E., & Dancer, S. J. (2017)
Control of Antimicrobial Resistance Requires an Ethical Approach. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.02124
Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the pro...

Hand antisepsis without decreasing efficacy by shortening the rub-in time of alcohol-based handrubs to 15 seconds

Journal Article
Harnoss, J., Dancer, S., Kaden, C., Baguhl, R., Kohlmann, T., Papke, R., …Kramer, A. (2020)
Hand antisepsis without decreasing efficacy by shortening the rub-in time of alcohol-based handrubs to 15 seconds. Journal of Hospital Infection, 104(4), 419-424. https://doi.org/10.1016/j.jhin.2019.09.004
Background A previous study among neonatal intensive care unit (NICU) nurses showed that the antibacterial efficacy of alcohol-based handrubs (ABHR) can be achieved in 15 s in...

Date


31 results

Cathelicidins as Novel Therapeutic Antivirals for Dengue Infection

2019 - 2022
A significant challenge faced by modern society is the lack of therapeutics for a large number of infections, particularly those that are endemic or widely spread in developing countries. Dengue is on...
Funder: Medical Research Council | Value: £269,873

Bacteriophage endolysins and novel lipid-degrading proteins as a treatment for Rhodococcus equi infections in foals

2018 - 2019
Rhodococcus equi (Req) is responsible for severe respiratory disease of foals with a major economic impact on the equine industry, and can be endemic on stud farms. In foals under 6 months of age, thi...
Funder: Horserace Betting Levy Board | Value: £10,832

Cathelicidins as novel therapeutic antiviral agents in Rhinovirus infection

2015 - 2017
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a...
Funder: Chief Scientists Office | Value: £163,152

MinION sequencing of bacterial isolates

2017 - 2020
MinION sequencing of bacterial isolates
Funder: Society of Applied Microbiology | Value: £2,500

TRANSFORM - Education reform project – Improving Research capability in the Sri Lankan Higher Education sector.

2018 - 2019
TRANSFORM - Education reform project – Improving Research capability in the Sri Lankan Higher Education sector.
Funder: British Council | Value: £75,000

IBD drug effect on autophagy (IDEA)

2017 - 2018
An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for treatment of paediatric IBD
Funder: Crohn's in Childhood Research Association | Value: £5,274

Developing an adoptive regulatory T cell therapy for the treatment of rheumatoid arthritis

2021 - 2024
The immune system contains a balance of cells that turn responses ‘on’ and those that turn it ‘off’. When this balance breaks down, inappropriate immune responses can attack healthy tissue...
Funder: Chief Scientists Office | Value: £229,020

Development of a UV-C hand-sanitiser unit

2017 - 2017
Development of a UV-C hand-sanitiser unit
Funder: Scottish Funding Council | Value: £5,000

Mechanism of Chlamydia induced progesterone resistance

2018 - 2019
Chlamydia trachomatis is the most common sexually-transmitted infection in the world, and is associated with miscarriage, pre-term birth and infertility. However, the understanding of the mechanisms t...
Funder: Society for Reproduction and Fertility | Value: £12,034

Students into Work

2014 - 2014
Salmonella enterica is a leading cause of foodborne infection with a recent increase in the number of antibiotic resistant isolates. We propose a biotechnological approach to the development of novel ...
Funder: Society of Applied Microbiology | Value: £2,717

Date


Research Areas

Themes